Mutation of a conserved CDK site converts a metazoan elongation factor 1Bβ subunit into a replacement for yeast eEF1Bα

Molecular Genetics and Genomics

Volumn 269, Issue 6, 2003, Pages 776-788

  Pomerening, J R ^a   Valente, L ^b   Kinzy, T G ^b,c   Jacobs, T W ^d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cyclin dependent kinase (CDK); Elongation factor; Interaction; Plant; Yeast

Indexed keywords

ALANINE; COMPLEMENTARY DNA; CYCLIN B; CYCLIN DEPENDENT KINASE; ELONGATION FACTOR 1ALPHA; ELONGATION FACTOR 1BETA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; PLANT EXTRACT; PROTEIN KINASE; PROTEIN SUBUNIT; RECOMBINANT ENZYME; REGULATOR PROTEIN; THREONINE; VEGETABLE PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CELL CYCLE; COLD SENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EUKARYOTE; FUNGUS MUTANT; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENETIC CODE; IN VITRO STUDY; IN VIVO STUDY; MEIOSIS; METAZOON; MITOSIS; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PEA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RICE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSLATION REGULATION; WILD TYPE; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CONSERVED SEQUENCE; CYCLIN-DEPENDENT KINASES; DNA PRIMERS; GENE LIBRARY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; MOLECULAR SEQUENCE DATA; MUTATION; ORYZA SATIVA; PEAS; PEPTIDE ELONGATION FACTOR 1; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PRECIPITIN TESTS; PROTEIN SUBUNITS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; EUKARYOTA; FUNGI; METAZOA; PISUM SATIVUM; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0141594713     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-003-0888-1     Document Type: Article

References (59)

1. Ach R, Durfee T, Miller A, Taranto L, Hanley-Bowdoin L, Zambryski P, Gruissem W (1997) RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein. Mol Cell Biol 17:5077-5086
2. Atherton-Fessler S, Parker L, Geahlen L, Piwnica-Worms H (1993) Mechanisms of p34cdc2 regulation. Mol Cell Biol 13:1675-1685
3. Bec G, Kerjan P, Waller J (1994) Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1βγδ complex. J Biol Chem 269:2086-2092
4. Bellé R, Minella O, Cormier P, Morales J, Poulhe R, Mulner-Lorillon O (1995) Phosphorylation of elongation factor-1 (EF-1) by cdc2 kinase. Prog Cell Cyc Res 1:265-270
5. Blanar M, Rutter W (1992) Interaction cloning: Identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science 256:1014-1018
6. Boeke J, Trueheart J, Natsoulis G, Fink G (1987) 5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol 154:164-175
7. Braun D, Stone J, Walker J (1997) Interaction of the maize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases-implications for transmembrane signaling in plants. Plant J 12:83-95
8. Brizuela L, Draetta G, Beach D (1987) p13Sucl acts in the fission yeast cell division cycle as a component of the cdc2 protein kinase. EMBO J 6:3507-3514
9. Browning K (1996) The plant translational apparatus. Plant Mol Biol 32:107-144
10. Carr-Schmid A, Valente L, Loik V, Williams T, Starita L, Kinzy T (1999) Mutations in elongation factor 1β, a guanine nucleotide exchange factor, enhance translational fidelity. Mol Cell Biol 19:5257-5266
11. Chang Y, Traugh J (1997) Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translation elongation. J Biol Chem 272:28252-28257
12. Creanor J, Mitchison J (1982) Patterns of protein synthesis during the cell cycle of the fission yeast Schizosaccharomyces pombe. J Cell Sci 58:263-285
13. De Nadal E, Fadden R, Ruiz A, Haystead T, Ariño J (2001) A role for the Ppz Ser/Thr phosphatases in the regulation of translation elongation factor 1Bα. J Biol Chem 276:14829-14834
14. De Veylder L, Beeckman T, Beemster G, Krols L, Terras F, Landrieu I, Van Der Schueren E, Maes S, Naudts M, Inzé D (2001) Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis. Plant Cell 13:1653-1667
15. De Veylder L, Beeckman T, Beemster G, de Almeida Engler J, Ormenese S, Maes S, Naudts M, Van Der Schueren E, Jacqmard A, Engler G, Inzé D (2002) Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO J 21:1360-1368
16. Fankhauser C, Marks J, Reymond A, Simanis V (1993) The S. pombe cdc16 gene is required both for maintenance of p34(cdc2) kinase activity and regulation of septum formation - a link between mitosis and cytokinesis. EMBO J 12:2697-2704
17. Gietz R, Sugino A (1988) New yeast- Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534
18. Guerrucci M, Monnier A, Delalande C, Bellé R (1999) The elongation factor-1δ (EF-1δ) originates from gene duplication of an EF-1β ancestor and fusion with a protein-binding domain. Gene 233:83-87
19. Ito H, Fukuda Y, Murata K, Kimura A (1983) Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153:163-168
20. Izumi T, Maller J (1991) Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions. Mol Cell Biol 11:3860-3867
21. Janssen G, Möller W (1988) Elongation factor 1 βγ from Artemia. Purification and properties of its subunits. Eur J Biochem 171:119-129
22. Janssen G, Maessen G, Amons R, Möller W (1988) Phosphorylation of elongation factor 1β by an endogenous kinase affects its catalytic nucleotide exchange activity. J Biol Chem 263:11063-11066
23. Janssen G, van Damme H, Kriek J, Amons R, Möller W (1994) The subunit structure of elongation factor 1 from Artemia: why two α-chains in this complex? J Biol Chem 269:31410-31417
24. Kanki J, Newport J (1991) The cell cycle dependence of protein synthesis during Xenopus laevis development. Dev Biol 146:198-213
25. King R, Deshaies R, Peters J, Kirschner M (1996) How proteolysis drives the cell cycle. Science 274:1652-1658
26. Kinzy T, Woolford J Jr (1995) Increased expression of Saccharomyces cerevisiae translation elongation factor 1α bypasses the lethality of a TEF5 null allele encoding elongation factor 1β. Genetics 141:481-489
27. Kinzy T, Ripmaster T, Woolford J Jr (1994) Multiple genes encode the translational elongation factor 1-γ in Saccharomyces cerevisiae. Nucleic Acids Res 22:2703-2707
28. Koepp D, Harper J, Elledge S (1999) How the cyclin became a cyclin: regulated proteolysis in the cell cycle. Cell 97:431-434
29. Kosugi S, Ohashi Y (2002) E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Plant J 29:45-59
30. Lacy M, Voss E (1986) A modified method to induce immune polyclonal ascites fluid in BALB/c mice using Sp2/0-Ag14 cells. J Immunol Methods 87:169-177
31. Mariconti L, Pellegrini B, Cantoni R, Stevens R, Bergounioux C, Cella R, Albani D (2002) The E2F family of transcription factors from Arabiodpsis thaliana. Novel and conserved components of the retinoblastoma/E2F pathway in plants. J Biol Chem 277:9911-9919
32. Merrick W (1979) Assays for eukaryotic protein synthesis. Methods Enzymol 60:108-123
33. Merrick W, Nyborg J (2000) The Protein biosynthesis elongation cycle. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
34. Minella O, Cormier P, Morales J, Poulhe R, Bellé R, Mulner-Lorillon O (1994) CDC2 kinase sets a memory phosphorylation signal on elongation factor EF-1δ during meiotic cell division, which perdures in early development. Cell Mol Biol 40:521-525
35. Minella O, Mulner-Lorillon O, Bec G, Cormier P, Bellé R (1998) Multiple phosphorylation sites and quaternary organization of guanine-nucleotide exchange complex of elongation factor-1 (EF-1βγ δ/ValRS) control the various functions of EF-1α. Biosci Rep 18:119-127
36. Mironov V, De Veylder L, Van Montagu M, Inzė D (1999) Cyclin-dependent kinases and cell division in plants-the nexus. Plant Cell 11:509-521
37. Monnier A, Bellé R, Morales J, Cormier P, Boulben S, Mulner-Lorillon O (2001) Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation. Nucleic Acids Res 29:1453-1457
38. cdc2: In vivo veritas? Cell 61:549-551
39. cdc2 substrate. FEBS Lett 251:219-224
40. Mulner-Lorillon O, Cormier P, Cavadore J, Morales J, Poulhe R, Bellé R (1992) Phosphorylation of Xenopus elongation factor-1γ by cdc2 protein kinase: Identification of the phosphorylation site. Exp Cell Res 202:549-551
41. Mulner-Lorillon O, Minella O, Cormier P, Jean-Paul C, Cavadore J, Morales J, Poulhe R, Bellé R (1994) Elongation factor EF-1δ, a new target for maturation-promoting factor in Xenopus oocytes. J Biol Chem 269:20201-20207
42. Pedersen L, Anderson G, Knudsen C, Kinzy T, Nyborg J (2001) Crystallization of the yeast elongation factor complex eEF1A-eEF1Bα. Acta Cryst D57:159-161
43. Peters H, Chang Y, Traugh J (1995) Phosphorylation of elongation factor 1 (EF-1) by protein kinase C stimulates GDP/GTP-exchange activity. Eur J Biochem 234:550-556
44. Pitluk Z, McDonough M, Sangan P, Gonda D (1995) Novel CDC34 (UBC3) ubiquitin-conjugating enzyme mutants obtained by charge-to-alanine scanning mutagenesis. Mol Cell Biol 15:1210-1219
45. Pomerening J, Sontag E, Ferrell J Jr (2003) Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2. Nat Cell Biol 5:346-351
46. Ramirez-Parra E, Xie Q, Boniotti M, Gutierrez C (1999) The cloning of plant E2F, a retinoblastoma-binding protein, reveals unique and conserved features with animal G(1)/S regulators. Nucleic Acids Res. 27:3527-3533
47. Redpath N, Price N, Severinov K, Proud C (1993) Regulation of elongation factor-2 by multisite phosphorylation. Eur J Biochem 213:689-699
48. Rosenthal E, Brandhorst B, Ruderman J (1982) Translationally mediated changes in patterns of protein synthesis during maturation of starfish oocytes. Dev Biol 91:215-220
49. Ryazanov A, Spirin A (1993) Phosphorylation of elongation factor 2: a mechanism to shut off protein synthesis for reprogramming gene expression. In: Ilan J (ed) Plenum Press, New York, pp 433-455
50. Sanders J, Raggiaschi R, Morales J, Moller W (1993) The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta. Biochim Biophys Acta 1174:87-90
51. Sekine M, Ito, M, Uemukai K, Maeda Y, Nakagami H, Shinmyo A (1999) Isolation and characterization of the E2F-like gene in plants. FEBS Lett 460:117-122
52. Sherman F, Fink G, Hicks J (1986) Methods in yeast genetics: A laboratory course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
53. Sheu G, Traugh J (1997) Recombinant subunits of mammalian elongation factor 1 (EF-1) expressed in E. coli; subunit interactions, elongation activity and phosphorylation by protein kinase CKII. J Biol Chem 272:33290-33297
54. Sheu G, Traugh J (1999) A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII. Mol Cell Biochem 191:181-186
55. Terui Y, Tsutsumi K, Kidou S, Sawazaki T, Kuroiwa Y, Yamaki M, Ejiri S (1998) A novel variant of translation elongation factor-1beta: isolation and characterization of the rice gene encoding EF-1beta2. Biochim Biophys Acta 1442:369-372
56. Venema R, Peters H, Traugh J (1991) Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities. J Biol Chem 266:11993-11998
57. Wang H, Qi Q, Schorr P, Cutler A, Crosby W, Fowke L (1998) ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis thaliana interacts with both Cdc2a and CycD3, and its expression is induced by abscisic acid. Plant J 15:501-510
58. Yamaguchi M, Umedea M, Uchimiya H (1998) A rice homolog of Cdk7/MO15 phosphorylates both cyclin-dependent protein kinases and the carboxy-terminal domain of RNA polymerase II. Plant J 16:613-619
59. Yang X, Hubbard J, Carlson M (1992) A protein kinase substrate identified by the two-hybrid system. Science 257:680-682