Are β-blockers efficacious as first-line therapy for hypertension in the elderly?

Current Hypertension Reports

Volumn 5, Issue 3, 2003, Pages 221-224

  Wink, Konrad ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; AMILORIDE PLUS HYDROCHLOROTHIAZIDE; ATENOLOL; BENDROFLUMETHIAZIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CHLORTALIDONE; DILTIAZEM; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROCHLOROTHIAZIDE; METHYLDOPA; PINDOLOL; PLACEBO; RESERPINE; CALCIUM CHANNEL BLOCKING AGENT; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (304 313); GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (304-313); PEPTIDE FRAGMENT;

ADULT; AGED; ANTIHYPERTENSIVE ACTIVITY; BLOOD PRESSURE REGULATION; CLINICAL TRIAL; CONFIDENCE INTERVAL; DIASTOLIC BLOOD PRESSURE; DRUG CHOICE; DRUG EFFICACY; GERIATRIC DISORDER; HUMAN; HYPERTENSION; MONOTHERAPY; MORBIDITY; MORTALITY; REVIEW; RISK REDUCTION; STATISTICAL SIGNIFICANCE; STROKE; SYSTOLIC BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR DISEASES; CEREBROVASCULAR ACCIDENT; CLINICAL TRIALS; DIURETICS; DRUG THERAPY, COMBINATION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; HYPERTENSION; PEPTIDE FRAGMENTS; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 0141576560     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-003-0024-y     Document Type: Review

References (9)

1. Messerli FH, Grossman E, Goldbourt U: Are β-blockers efficacious as firstline therapy for hypertension in the elderly? A systematic review. JAMA 1998, 279:1903-1907.
2. Dahlöf B, Lindholm LH, Hansson L, et al.: Morbidity and mortality in the Swedish Trial in Old Patients with Hypertension (STOP-Hypertension). Lancet 1991, 388:1281-1285.
3. SHEP Cooperative Research Group: Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. JAMA 1991, 265:3255-3264.
4. MRC Working Party: Medical Research Council trial of treatment of hypertension in older adutls: principal results. BMJ 1992, 304:405-412.
5. Coope J, Warrender THS: Randomised trial of treatment of hypertension in elderly patients in primary care. BMJ 1986, 293:1145-1151.
6. Hansson L, Lindholm LH, Ekbom T, et al., for the STOP-Hypertension-2 study group: Randomised trial of old and new nti-hypertensive drugs in elderly patients; cardiovascular mortality and morbidity in the Swedish Trial in Old Patients with Hypertesion-2 study. Lancet 1999, 354:1751-1756.
7. Hansson L, Hedner TH, Lund-Johansen P, et al., for the NOR-DIL Study Group: Radomised trial of effects of calcium antagonists compared with diuretics and β-blockers on cardiovascular morbidity and mortality in hypertension: Nordic Diltiazem (NORDIL) study. Lancet 2000, 356:359-365.
8. Lever AF, Brenna PJ, MRC trial of treatment in elderly hypertensives. High Blood Press 1992, 1:132-137.
9. Kostis JB, Berge KG, Effects of atenolol and reserpine on selected events in the Systolic Hypertension in the Elderly Program (SHEP). Am J Hypertens 1995, 8:1147-1153.