Skeletal muscle basal AMP-activated protein kinase activity is chronically elevated in alloxan-diabetic dogs: Impact of exercise

Journal of Applied Physiology

Volumn 95, Issue 4, 2003, Pages 1523-1530

  Christopher, Michael J ^a,b   Chen, Zhi Ping ^c   Rantzau, Christian ^a,b   Kemp, Bruce E ^c   Alford, Frank P ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Acetyl coenzyme A carboxylase; Glucose and fatty acid metabolism; Hyperglycemia; Hypoinsulinemia; Phlorizin induced normoglycemia

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE PHOSPHATE; ADENOSINE PHOSPHATE PROTEIN KINASE ALPHA1; ADENOSINE PHOSPHATE PROTEIN KINASE ALPHA2; ALLOXAN; GLUCOSE; INSULIN; PHLORIZIN; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOG; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; MALE; MUSCLE BIOPSY; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TREADMILL EXERCISE;

EID: 0141567082     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00199.2003     Document Type: Article

References (48)

1. Bergeron R, Russell RR 3rd, Young LH, Ren JM, Marcucci M, Lee A, and Shulman GI. Effect of AMPK activation on muscle glucose metabolism in conscious rats. Am J Physiol Endocrinol Metab 276: E938-E944, 1999.
2. Chen ZP, Heierhorst J, Mann RJ, Mitchelhill KI, Michell BJ, Witters LA, Lynch GS, Kemp BE, and Stapleton D. Expression of the AMP-activated protein kinase β1 and β2 subunits in skeletal muscle. FEBS Lett 460: 343-348, 1999.
3. Chen ZP, McConell GK, Michell BJ, Snow RJ, Canny BJ, and Kemp BE. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab 279: E1202-E1206, 2000.
4. Chen ZP, Mitchelhill KI, Michell BJ, Stapleton D, Rodriguez-Crespo I, Witters LA, Power DA, Ortiz de Montellano PR, and Kemp BE. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 443: 285-289, 1999.
5. Christopher MJ, Rantzau C, Ward GM, and Alford FP. Impact of variable insulinemia and glycemia on in vivo glycolysis and glucose storage in dogs. Am J Physiol Endocrinol Metab 266: E62-E71, 1994.
6. Christopher MJ, Rantzau C, Ward GM, and Alford FP. Insulinopenia and hyperglycemia influence the in vivo partitioning of GE and SI. Am J Physiol Endocrinol Metab 268: E410-E421, 1995.
7. Christopher MJ, Sleeman MW, Alford FP, and Best JD. Contrasting action of short- and long-term adrenaline infusion on dog skeletal muscle glucose metabolism. Diabetologia 35: 399-405, 1992.
8. Coker RH, Krishna MG, Brooks Lacy D, Allen EJ, and Wasserman DH. Sympathetic drive to liver and nonhepatic splanchnic tissue during heavy exercise. J Appl Physiol 82: 1244-1249, 1997.
9. Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, and Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes 49: 1295-1300, 2000.
10. Derave W, Ai H, Ihlemann J, Witters LA, Kristiansen S, Richter EA, and Ploug T. Dissociation of AMP-activated protein kinase activation and glucose transport in contracting slow-twitch muscle. Diabetes 49: 1281-1287, 2000.
11. Finegood DT, Miles PD, Lickley HL, and Vranic M. Estimation of glucose production during exercise with a one-compartment variable-volume model. J Appl Physiol 72: 2501-2509, 1992.
12. Fisher SJ, Lekas M, Shi ZQ, Bilinski D, Carvalho G, Giacca A, and Vranic M. Insulin-independent acute restoration of euglycemia normalizes the impaired glucose clearance during exercise in diabetic dogs. Diabetes 46: 1805-1812, 1997.
13. Fryer LG, Parbu-Patel A, and Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem 277:25226-25232, 2002.
14. Fujii N, Hayashi T, Hirshman MF, Smith JT, Habinowski SA, Kaijser L, Mu J, Ljungqvist O, Birnbaum MJ, Witters LA, Thorell A, and Goodyear LJ. Exercise induces isoform-specific increase in 5′AMP-activated protein kinase activity in human skeletal muscle. Biochem Biophys Res Commun 273: 1150-1155, 2000.
15. Halse R, Fryer LG, McCormack JG, Carling D, and Yeaman SJ. Regulation of glycogen synthase by glucose and glycogen. A possible role for AMP-activated protein kinase, Diabetes 52: 9-15, 2003.
16. Hawley SA, Gadalla AE, Olsen GS, and Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 51: 2420-2425, 2002.
17. Hayashi T, Hirshman MF, Fujii N, Habinowski SA, Witters LA, and Goodyear LJ. Metabolic stress and altered glucose transport. Activation of AMP-activated protein kinase as a unifying coupling mechanism. Diabetes 49: 527-531, 2000.
18. Hayashi T, Hirshman MF, Kurth EJ, Winder WW, and Goodyear LJ. Evidence for 5′AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47: 1369-1373, 1998.
19. Hespel P, Vergauwen L, Vandenberghe K, and Richter EA. Important role of insulin and flow in stimulating glucose uptake in contracting skeletal muscle. Diabetes 44: 210-215, 1995.
20. Hother-Nielsen O, Henriksen JE, Holst JJ, and Beck-Nielsen H. Effects of insulin on glucose turnover rates in vivo: isotope dilution versus constant specific activity technique. Metabolism 45: 82-91, 1996.
21. Kemp BE, Mitchelhill KI, Stapleton D, Michell BJ, Chen ZP, and Witters LA. Dealing with energy demand: the AMP-activated protein kinase (Review). Trends Biochem Sci 24: 22-25, 1999.
22. Kennedy JW, Hirshman MF, Gervino EV, Ocel JV, Armour Forse R, Hoenig SJ, Aronson D, Goodyear LJ, and Horton ES. Acute exercise induces GLUT4 translocation in skeletal muscle of normal human subjects and subjects with Type 2 diabetes. Diabetes 48: 1192-1197, 1999.
23. Kurth-Kraczek EJ, Hirshman MF, Goodyear LJ, and Winder WW. 5′AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle. Diabetes 48: 1667-1671, 1999.
24. Lussier B, Vranic M, Kovacevic N, and Hetenyi G. Glucoregulation in alloxan-diabetic dogs. Metabolism 35: 18-24, 1986.
25. Martin IK, Katz A, and Wahren J. Splanchnic and muscle metabolism during exercise in NIDDM patients. Am J Physiol Endocrinol Metab 269: E583-E590, 1995.
26. Merrill GF, Kurth EJ, Hardie DG, and Winder WW. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol Endocrinol Metab 273: E1107-E1112, 1997.
27. Muoio DM, Seefeld K, Witters LA, and Coleman RA. AMP-activated kinase reciprocally regulates triacyglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338: 783-791, 1999.
28. Musi N, Fujii N, Hirshman MF, Ekberg I, Fröberg S, Ljungqvist O, Thorell A, and Goodyear LJ. AMP-activated protein kinase (AMPK) is activated in muscle of subjects with Type 2 diabetes during exercise. Diabetes 50: 921-927, 2001.
29. Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, and Winder WW. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol 92: 2475-2482, 2002.
30. Peltoniemi P, Yki-Järvinen H, Oikonen V, Oksanen A, Takala TO, Rönnemaa T, Erkinjuntti M, Knuuti MJ, and Nuutila P. Resistance to exercise -induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with Type 1 diabetes. Diabetes 50: 1371-1377, 2001.
31. Putman CT, Jones NL, Lands LC, Bragg TM, Hollidge-Horvat MG, and Heigenhauser GJ. Skeletal muscle pyruvate activity during maximal exercise in humans. Am J Physiol Endocrinol Metab 269: E458-E468, 1995.
32. Raguso CA, Coggan AR, Gastaldelli A, Sidossis LS, Bastyr EJ 3rd, and Wolfe RR. Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise. Diabetes 44: 1066-1074, 1995.
33. Rasmussen BB and Winder WW. Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase. J Appl Physiol 83: 1104-1109, 1997.
34. Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, and Wolfe RR. Regulation of endogenous fat and carbohydrate metbolism in relation to exercise intensity and duration. Am J Physiol Endocrinol Metab 265: E380-E391, 1993.
35. Sleeman MW, Christopher MJ, Martin IK, Ward GW, Alford FP, and Best JD. Effects of acute and chronic counter-regulatory hormone infusions on glucose tolerance and insulin sensitivity in diabetic dogs. Diabetes 41: 1446-1452, 1992.
36. α2 activity and acetyl-CoA carboxylase phosphorylation during exercise. Am J Physiol Endocrinol Metab 282: E688-E694, 2002.
37. Van Loon LJ, Greenhaff PL, Constantin-Teodosiu D, Saris WH, and Wagenmakers AJ. The effects of increasing exercise intensity on muscle fuel utilization in humans. J Physiol 536: 295-304, 2001.
38. Viollet B, Andreelli F, Jorgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, and Vaulont S. The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest 111: 91-98, 2003.
39. Wasserman DH, Bupp JL, Johnson JL, Bracy D, and Lacy DB. Glucoregulation during rest and exercise in depancreatized dogs: role of the acute presence of insulin. Am J Physiol Endocrinol Metab 262: E574-E582, 1992.
40. Wasserman DH, Lickley HL, and Vranic M. Important role of glucagon during exercise in diabetic dogs. J Appl Physiol 59: 1272-1281, 1985.
41. Winder WW and Hardie DG. AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. Am J Physiol Endocrinol Metab 277: E1-E10, 1999.
42. Wojtaszewski JF, Jorgensen SB, Hellsten Y, Hardie DG, and Richter EA. Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. Diabetes 51: 284-292, 2002.
43. Wojtaszewski JF, Macdonald C, Nielsen JN, Hellsten Y, Hardie DG, Kemp BE, Kiens B, and Richter EA. Regulation of 5′AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab 284: E813-E822, 2003.
44. Wojtaszewski JF, Nielsen P, Hansen BF, Richter EA, and Kiens B. Isoform-specific and exercise intensity-dependent activation of 5′-AMP-activated protein kinase in human skeletal muscle. J Physiol 528: 221-226, 2000.
45. Wright EM, Turk E, Zabel B, Mundlos S, and Dyer J. Molecular genetics of intestinal glucose transport. J Clin Invest 88:1435-1440, 1991.
46. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, and Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174, 2001.
47. Zierath JR, He L, Guma A, Odegoard Wahlstrom E, Klip A, and Wallberg-Henriksson H. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39: 1180-1189, 1996.
48. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, and Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6: 924-928, 2000.