Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 21, 2003, Pages 3693-3699

  Peng, Hui ^a   Huang, Niu ^a   Qi, Jing ^a   Xie, Ping ^b   Xu, Chen ^a   Wang, Jianxiang ^a   Yang, Chunzheng ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; IMATINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; BIOASSAY; CHRONIC MYELOID LEUKEMIA; DATA BASE; DRUG ANALYSIS; DRUG IDENTIFICATION; ENZYME ACTIVE SITE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PROTEIN PHOSPHORYLATION;

EID: 0141545126     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.08.014     Document Type: Article

References (17)

1. Rowley J.D. Nature. 243:1973;290.
2. Advani A.S., Pendergast A.M. Leuk. Res. 26:2002;713.
3. Dai Z., Quackenbush R.C., Courtney K.D., Grove M., Cortez D., Reuther G.W., Pendergast A.M. Genes Dev. 12:1998;1415.
4. Evans C.A., Owen-Lynch P.J., Whetton A.D., Dive C. Cancer Res. 53:1993;1735.
5. Daley G.Q., Van Etten R.A. Science. 247:1990;824.
6. Lugo T.G., Pendergast A.M., Muller A.J., Witte O.N. Science. 247:1990;1079.
7. Sawyers C.L., Callahan W., Witte O.N. Cell. 70:1992;901.
8. Afar D.E., Goga A., McLaughlin J., Witte O.N., Sawyers C.L. Science. 264:1994;424.
9. Sawyers C.L. N. Engl. J. Med. 340:1999;1330.
10. Jahagirdar B.N., Miller J.S., Shet A., Verfaillie C.M. Exp. Hematol. 29:2001;543.
11. Druker B.J., Talpaz M., Resta D.J., Peng B., Buchdunger E., Ford J.M., Lydon N.B., Kantarjian H., Capdeville R., Ohno-Jones S., Sawyers C.L. N. Engl. J. Med. 344:2001;1031.
12. Gorre M.E., Mohammed M., Ellwood K., Hsu N., Paquette R., Rao P.N., Sawyers C.L. Science. 293:2001;876.
13. Schindler T., Bornmann W., Pellicena P., Miller W.J., Clarkson B., Kuriyan J. Science. 289:2000;1938.
14. Kuntz I.D. Science. 257:1992;1078.
15. Ewing T.J.A., Kuntz I.D. J. Comput. Chem. 18:1997;1175.
16. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Adv. Drug Deliv. Res. 23:1997;3.
17. Druker B., Okuda K., Matulonis U., Salgia R., Roberts T., Griffin J.D. Blood. 79:1992;2215.