d4TMP delivery from 7-substituted cycloSal-d4TMPs

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 825-827

  Meier, C ^a   Renze, J T ^a   Balzarini, J ^b   De Clercq, E ^b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

CycloSal; Nucleotide delivery; Pronucleotides

Indexed keywords

CYCLOSALIGENYL 2',3' DIDEHYDRO 2',3' DIDEOXYTHYMIDINE PHOSPHATE; DIDEOXYTHYMIDINE PHOSPHATE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE;

HALF-LIFE; HYDROLYSIS; KINETICS; PRODRUGS; THYMIDINE;

EID: 0141537124     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022663     Document Type: Conference Paper

References (3)

1. Meier, C. cycloSal-pronuceotides - design of chemical trojan horses. Mini Reviews Med. Chem. 2002, 2, 219-234.
2. Balzarini, J.; Aquaro, S.; Knispel, T.; Rampazzo, C.; Bianchi, V.; Perno, C.-F.; De Clercq, E. cycloSaligenyl-2′,3′-didehydro-2′ ,3′-dideoxythymidine monophosphate: Efficient intracellular delivery of d4TMP. Mol. Pharmacol. 2000, 58, 928-935.
3. Renze, J.; Plath, M.; Ducho, C.; Balzarini, J.; De Clercq, E.; Meier, C. Benzyl-functionalized cycloSal-d4T monophosphates. Nucl. Nucl. & Nucleic Acids 2001, 20, 931-934.