The photosensitiser xanthurenic acid is not present in normal human lenses

Experimental Eye Research

Volumn 77, Issue 5, 2003, Pages 547-553

  Hains, Peter G ^a   Gao, Ling ^a   Truscott, Roger J W ^a,b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

3 hydroxykynurenine; Aging; Cataract; Human lens; UV light; Xanthurenic acid

Indexed keywords

3 HYDROXYKYNURENINE; PHOTOSENSITIZING AGENT; XANTHURENIC ACID;

AGING; AIR; ARTICLE; AUTOOXIDATION; BIOFILTER; CATARACT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LENS; LIGHT; MASS SPECTROMETRY; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

EID: 0141534102     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4835(03)00194-5     Document Type: Article

References (26)

1. Bessems G.J., Hoenders H.J. Distribution of aromatic and fluorescent compounds within single human lenses. Exp. Eye Res. 44:1987;817-824.
2. Bova L.M., Wood A.M., Jamie J.F., Truscott R.J.W. UV filter compounds in human lenses: the origin of 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-β-D-glucoside. Invest. Ophthal. Vis. Sci. 40:1999;3237-3244.
3. Bova L.M., Sweeney M.H.J., Jamie J.F., Truscott R.J.W. Major changes in human ocular UV protection with age. Invest. Ophthal. Vis. Sci. 42:2001;200-205.
4. Buckingham R.H. The behaviour of reduced proteins from normal and cataractous lenses in highly dissociating media: a cross-linked protein in cataractous lenses. Exp. Eye Res. 14:1972;123-129.
5. Davies M.J., Truscott R.J.W. Photo-oxidation of proteins and its role in cataractogenesis. J. Photochem. Photobiol. B. 63:2001;114-125.
6. Dillon J., Wang R.H., Atherton S.R. Photochemical and photophysical studies on human lens constituents. Photochem. Photobiol. 52:1990;849-854.
7. Dillon J., Zheng L., Merriam J.C., Gaillard E.R. Transmission spectra of light to the mammalian retina. Photochem. Photobiol. 71:2000;225-229.
8. Garner B., Vazquez S., Griffith R., Linders R.A., Carver J.A., Truscott R.J.W. Identification of glutathionyl-3-hydroxykynurenine glucoside as a novel fluorophore associated with aging of the human lens. J. Biol. Chem. 574:1999;20847-20854.
9. Goosey J.D., Zigler J.S. Jr., Kinoshita J.H. Cross-linking of lens crystallins in a photodynamic system: a process mediated by singlet oxygen. Science. 208:1980;1278-1280.
10. Hiller R.L.G., Yuen K. Sunlight and cataract: an epidemiology investigation. Am. J. Epidemiol. 105:1977;450-459.
11. Malina H.Z., Martin X.D. Deamination of 3-hydroxykynurenine in bovine lenses: a possible mechanism of cataract formation in general. Graefes Arch. Clin. Exp. Ophthalmol. 233:1995;38-44.
12. Malina H.Z., Martin X.D. Xanthurenic acid derivative formation in the lens is responsible for senile cataract in humans. Graefes Arch. Clin. Exp. Ophthalmol. 234:1996;723-730.
13. Reddy V.N. Glutathione and its function in the lens - an overview. Exp. Eye Res. 50:1990;771-778.
14. Roberts J.E., Wishart J.F., Martinez L., Chignell C.F. Photochemical studies on xanthurenic acid. Photochem. Photobiol. 72:2000;467-471.
15. Roberts J.E., Finley E.L., Patat S.A., Schey K.L. Photo-oxidation of lens protein with xanthurenic acid: a putative chromophore for cataractogenesis. Photochem. Photobiol. 74:2001;740-744.
16. Shirao E., Ando K., Inoue A., Shirao Y., Balasubramanian D. Identification of a novel fluorophore, xanthurenic acid 8-O-β-D-glucoside in human brunescent cataract. Exp. Eye Res. 73:2001;421-431.
17. Taylor L.M., Aquilina J.A., Jamie J.F., Truscott R.J.W. UV filter instability: consequences for the human lens. Exp. Eye Res. 75:2002;165-175.
18. Thiagarajan G., Shirao E., Ando K., Inoue A., Balasubramanian D. Role of xanthurenic acid 8-O-β-D-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens. Photochem. Photobiol. 76:2002;368-372.
19. Tokuyama T., Senoh S., Sakan T., Brown K.S., Witkop B. The photoreduction of kynurenic acid to kynurenine yellow and the occurrence of 3-hydroxykynurenine in butterflies. J. Am. Chem. Soc. 89:1967;1017-1021.
20. Truscott R.J.W., Augusteyn R.C. Changes in human lens proteins during nuclear cataract formation. Exp. Eye Res. 24:1977;159-170.
21. Truscott R.J.W., Augusteyn R.C. Oxidative changes in human lens proteins during senile nuclear cataract formation. Biochim. Biophys. Acta. 492:1977;43-52.
22. Truscott R.J.W., Augusteyn R.C. The state of sulphydryl groups in normal and cataractous human lenses. Exp. Eye Res. 25:1977;139-148.
23. Van Heyningen R. Fluorescent glucoside in the human lens. Nature. 230:1971;393-394.
24. Van Heyningen R. Photo-oxidation of lens proteins by sunlight in the presence of fluorescent derivatives of kynurenine isolated from the human lens. Exp. Eye Res. 17:1973;137-147.
25. West S.K., Duncan D.D., Munoz B., Rubin G.S., Fried L.P., Bandeen-Roche K., Schein O.D. Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation Project. JAMA. 280:1998;714-718.
26. Wood A.M., Truscott R.J.W. UV filters in human lenses: tryptophan catabolism. Exp. Eye Res. 56:1993;317-325.