The effect of L-carnitine on the prevention of experimentally induced myringosclerosis in rats

Hearing Research

Volumn 184, Issue 1-2, 2003, Pages 107-112

  Akbaş, Yücel ^a   Pata, Yavuz Selim ^a   Görür, Kemal ^a   Polat, Gürbüz ^a   Polat, Ayşe ^a   Özcan, Cengiz ^a   Unal, Murat ^a  

^a MERSIN UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Carnitine; Myringosclerosis; Myringotomy; Reactive oxygene species; Tympanic membrane

Indexed keywords

ACETYLCHOLINESTERASE; CARNITINE; MALONALDEHYDE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE SEVERITY; EAR DISEASE; EARDRUM; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MICROSCOPY; MYRINGOSCLEROSIS; MYRINGOTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; SCLEROSIS;

EID: 0141527372     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5955(03)00229-6     Document Type: Article

References (31)

1. Arslan E., Milcan A., Unal S., Demirkan F., Polat A., Bagdatoglu O., Aksoy A., Polat G. The effects of carnitine on distally-burned dorsal skin flap: an experimental study in rats. Burns. 29(3):2003;221-227.
2. Asiri S., Hasham A., Al Anazy F., Zakzouk S., Banyar A. Tympanosclerosis: review of literature and incidence among patients with middle-ear infection. J. Laryngol. Otol. 113:1999;1076-1080.
3. Brevetti, G., Perna, S., 1992. Metabolic and clinical effects of L-carnitine in peripheral vascular disease. In: Ferrari, R., DiMauro, S., Sherwood, G. (Eds.), L-Carnitine and Its Role in Medicine: From Function to Therapy. Academic Press, London, pp. 359-378.
4. Dursun G., Acar A., Turgay M., Calguner M. Human leucocyte antigens in tympanosclerosis. Clin. Otolaryngol. 22:1997;62-64.
5. Efron D.T., Thornton F.J., Stevten C., Tantry U.S., Witte M.B., Kiyama T., Barbul A. Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing. J. Gastrointest. Surg. 3:1999;592-601.
6. Fabriello R.G., Calabrese F. Prevention of ischemia induced increase in MDA by acetyl carnitine. Ann. Neurol. 24:1988;114-118.
7. Fabriello R.G., Ferrano T.G., Golden G.T., Demattei M. Systemic acetyl-L-carnitine elevates nigral levels of glutathion and GABA. Life Sci. 43:1988;289-292.
8. Felding J.U., Rasmusen J.B., Lildholdt T. Gas composition of the normal and ventilated middle ear cavity. Scand. J. Clin. Lab. Invest. 47:(Suppl. 186):1987;31-41.
9. Gibb A.G. Tympanosclerosis. Proc. R. Soc. Med. 69:1976;155-162.
10. Görür K., Özcan C., Polat A., Unal M., Tamer L., Cinel I. The antioxidant and anti-apoptotic activities of selenium in the prevention of myringosclerosis in rats. J. Laryngol. Otol. 116:2002;426-429.
11. Kaygusuz I., Ozturk A., Ustundag B., Yalcin S. Role of free oxygen radicals in noise-related hearing impairment. Hear. Res. 162:2001;43-47.
12. Kelley E.E., Wagner B.A., Beuttner G.R., Burns C.P. Nitric oxide inhibits iron induced lipid peroxidation in HL-60 cells. Arch. Biochem. Biophys. 370:1999;97-104.
13. Kojima H., Miyazaki H., Tanaka Y., Shiwa M., Koga T., Moriyama H. Role of Bcl-xL protein in differentiation and apoptosis of human middle ear cholesteatoma epithelium. Arch. Otolaryngol. Head Neck Surg. 125:1999;738-742.
14. Lowitt S., Malone J.I., Salem A.F., Korhals J., Benford S. Acetyl-L-carnitine corrects the altered peripheral nerve function of experimental diabetes. Metabolism. 445:1995;677-680.
15. Mattson C., Marklund S.L., Hellstrom S. Aplication of oxygen free radical scavenger to diminish the occurrence of myringosclerosis. Ann. Otol. Rhinol. Laryngol. 106:1997;513-518.
16. Mayes, P.A., 2000. Lipids of physiologic significance. In: Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W. (Eds.), Harper's Biochemistry, 25th edn. Appleton and Lange, Stamford, pp. 160-171.
17. Mostafapour S.P., Hockenbery D.M., Rubel E.W. Life and death in otolaryngology: Mechanisms of apoptosis and its role in the pathology and treatment of disease. Arch. Otolaryngol. Head Neck Surg. 125:1999;729-737.
18. Murray, R.K., 2000. The biochemical basis of some neuropsychiatric disorders. In: Murray, R.K., Granner, D.K., Mayes, P.A., Rodwell, V.W. (Eds.), Harper's Biochemistry, 25th edn. Appleton and Lange, Stamford, pp. 829-849.
19. Okhawa H., Ohishi N., Yagi K. Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351.
20. Özcan C., Görür K., Cinel L., Talas D.U., Unal M., Cinel I. The inhibitory effect of topical N-acetylcysteine application on myringosclerosis in perforated rat tympanic membrane. Int. J. Pediatr. Otorhinolaryngol. 63:2002;179-184.
21. Özcan C., Polat G., Görür K., Talas D.U., Bagdatoglu O., Cinel I. The effect of local administration of N-acetylcysteine in perforated rat tympanic membrane: An experimental study in myringosclerosis. Pharmacol. Res. 45:2002;5-9.
22. Pata, Y.S., Akbaş, Y., Aydýn, O., Görür, K., Özcan, C., Polat, G., 2003. Prevention of laryngotracheal stenosis with carnitine after tracheotomy: an experimental study in rats. Int. J. Pediatr. Otolaryngol. 67, 881-888.
23. Sade J., Luntz M. Dynamic measurements of gas composition in the middle ear. II: Steady state value. Acta Otolaryngol. (Stockh.). 113:1993;353-357.
24. Schiff M., Yoo I.J. Immunologic aspects of otologic disease. An overview. Laryngoscope. 95:1985;256-269.
25. Stumpf D.E., Parker W.D., Angelini C. Carnitine deficiency, organic acidemias and Reye's syndrome. Neurology. 35:1985;1041.
26. Talas D.U., Nayci A., Polat G., Atis S., Comelekoglu U., Bagdatoglu O.T., Bagdatoglu C. The effects of dexamethasone on lipid peroxidation and nitric oxide levels on the healing of tracheal anastomoses: An experimental study in rats. Pharmacol. Res. 46:2002;265-271.
27. Tos M., Bonding P., Poulsen G. Tympanosclerosis of the drum in secretory otitis media. Acta Otolaryngol. Suppl. 414:1984;171-177.
28. Tos M., Bonding P., Poulsen G. Tympanosclerosis grommets. A prospective, comparative study. J. Laryngol. Otol. 97:1993;489-496.
29. Visioli, O., Pasini, E., de Giuli, F., Ferrari, R., 1992. Molecular mechanism of action of L-carnitine in treatment of myocardial disorders at the experimental levels. In: Ferrari, R., DiMauro, S., Sherwood, G. (Eds.), L-Carnitine and Its Role in Medicine: From Function to Therapy. Academic Press, London, pp. 237-263.
30. Wielinga E., Kerr A.G. Tympanosclerosis. Rev. Clin. Otolaryngol. 18:1993;341-349.
31. Zollner F. Tympanosclerosis. J. Laryngol. Otol. 70:1956;77-85.