Treatment of mice with a herbal preparation (mentat) protects against radiation-induced mortality

Phytotherapy Research

Volumn 17, Issue 8, 2003, Pages 876-881

  Jagetia, Ganesh Chandra ^a   Baliga, Manjeshwar Shrinath ^a  

^a KASTURBA MEDICAL COLLEGE   (India)

Author keywords

Mentat; Mice; Radiation; Radioprotection; Survival; Toxicity

Indexed keywords

ABANA; AMIFOSTINE; BOERHAAVIA DIFFUSA EXTRACT; BR 16A; GARLIC EXTRACT; GINGER EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; LIV 52; OCIMUM SANCTUM EXTRACT; PHYLLANTHUS NIRURI EXTRACT; RADIOPROTECTIVE AGENT; RASAYANA; SPIRULINA PLATENSIS EXTRACT; UNCLASSIFIED DRUG; WITHANIA SOMNIFERA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOERHAAVIA DIFFUSA; BONE MARROW DISEASE; CHLORELLA VULGARIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG FORMULATION; GAMMA IRRADIATION; GARLIC; GASTROINTESTINAL DISEASE; GINKGO BILOBA; GINSENG; LD 50; MEDICINAL PLANT; MOUSE; NONHUMAN; OCIMUM SANCTUM; PHYLLANTHUS NIRURI; RADIATION PROTECTION; RADIATION SICKNESS; SPIRULINA PLATENSIS; WITHANIA SOMNIFERA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA RAYS; INJECTIONS, INTRAPERITONEAL; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS;

EID: 0141515193     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1142     Document Type: Article

References (55)

1. Agarwal A, Dubey ML, Agarwal U, Dubey GP. 1991. EEG pattern of mentally deficient children and the effect of photic stimulation and mentat. Probe 3: 265-264.
2. Agarwal A, Dubey ML, Dubey GP. 1990. Effect of mentat on short-term memory span among normal adults. Pharmacopsychoecologia 3: 39-42.
3. Ahmed RS, Seth V, Pasha ST, Banerjee BD. 2000. Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats. Food Chem Toxicol 38: 443-450.
4. Alaoui-Youssefi A, Lamproglou I, Drieu K, Emerit I. 1999. Anticlastogenic effects of Gingo biloba extract (EGb 761) and some of its constituents in irradiated rats. Mutat Res 445: 99-104.
5. Banerjee S, Sharma R, Kale RK, Rao AR. 1994. Influence of certain essential oils on carcinogen metabolizing enzymes and acid-soluble sulfhydryls in mouse liver. Nutr Cancer 21: 263-269.
6. Bharali R, Banerjee S, Kumar SPV, Rao AR. 1998. Role of some spice essential oils in modulating mouse hepatic antioxidant enzymes, lipid peroxidation and DNA sugar damage for cancer chemoprevention. Proceedings International Conference on Radiation Biology: DNA Damage, Repair and Carcinogenesis. 64.
7. CHEMEXCIL. 1992. Selected medicinal plants of India. Basic chemicals, pharmaceutical and cosmetic export promotion council. Bombay, India.
8. Chitra M, Shyamala Devi CS. 1994. Protective action of embelin against lipid peroxidation on tumor bearing mice. Fitoterapia 65: 317-321.
9. D'Souza BD, Chavada KB. 1991. Mentat in hyperactivity and attention deficiency disorders-A double blind, placebo controlled study. Probe 3: 227-232.
10. Dadkar VN. 1991. Effect of mentat, a herbal preparation on the metrazole-induced seizures and restrained stress ulcers-preliminary findings in a controlled study. Probe 3: 268-272.
11. Ganasoundari A, Uma Devi P, Rao MNA. 1997. Protection against radiation-induced chromosome damage in mouse bone marrow by Ocimum sanctum. Mutat Res 373: 271-276.
12. Ganapathi NG, Jagetia GC. 1995. Liv. 52 pretreatment inhibits the radiation-induced lipid peroxidation in mouse liver. Curr Sci 68: 601-603.
13. Ghosh MN. 1984. Toxicity studies: Fundamentals of experimental pharmacology, Ghosh MN (ed.). Scientific Book Agency: Calcutta, India; 153-158.
14. Jagetia GC, Aruna R. 1997. The herbal preparation abana protects against radiation-induced micronuclei in the mouse bone marrow. Mutat Res 393: 157-163.
15. Jagetia GC, Ganapathi NG. 1991. Treatment of mice with a herbal preparation (Liv. 52) reduces the frequency of radiation induced chromosome damage in bone marrow. Mutat Res 253: 123-126.
16. Jagetia GC, Ganapathi NG. 1989. Inhibition of clastogenic effect of radiation by Liv. 52 in the bone marrow of mice. Mutat Res 224: 507-510.
17. Jagetia GC, Uma Devi P, Singatgeri MK, et al. 1986. Radiation modifying effect of Ocimum sanctum mouse survival studies. Proceeding, 56th Annual Session of the National Academy of Science India. 40.
18. Jitoe A, Masuda T, Tengah IGP, et al. 1989. Antioxidant activity of tropical ginger extracts and analysis of the contained curcuminoids. Med Hypotheses 29: 25-28.
19. Jose K, Kuttan R. 1995. Inhibition of exygen free radicals by Embelica officinales extract and chyavanprash. Amala Res Bull 15: 46-52.
20. Koti ST. 1991. Effect of mentat on school student's performance: a double blind, placebo-controlled study. Probe 3: 250-255.
21. Kulkarni SK, Verma A. 1992. Evidence for nootropic effect of BR-16A (mentat), a herbal psychotropic preparation, in mice. Ind J Physiol Pharmacol 36: 29-34.
22. Kumar PV, Kuttan R, Kuttan G. 1996. Radioprotective effects of Rasayanas. Ind J Exp Biol 34: 848-850.
23. Kuttan G. 1996. Use of Withania somnifera as adjuvant during radiation therapy. Ind J Exp Biol 34: 854-856.
24. 50/30 days. Radiat Res 105: 276-281.
25. Mehta UR. 1991. Therapy of mentally backward children with or without behavior disorders. Probe 3: 233-239.
26. Nadkarni AK. 1976. Indian Materia Medica, 3rd edition, Popular Press Ltd: Mumbai, India; 1308-1315.
27. Naiwu F, Lanping Q, Lei H, et al. 1992. Antioxidant action of extracts of Terminalia chebula and its preventive effect on DNA breaks in human white cells induced by TPA. Chinese Trad Herbal Drugs 23: 26-29.
28. Patt HM, Tyree EB, Straube RL, Smith DE. 1949. Cysteine protection against X-irradiation. Science 110: 213-214.
29. Prieur DJ, Young DM, Davis RD, et al. 1973. Procedures for preclinical toxicologic evaluation of cancer chemotherapeutic agents: protocols of the laboratory of toxicology. Cancer Chemother Rep 4: 1-28.
30. Qishen P, Baojing G, Kolman A. 1989. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test. Toxicol Lett 48: 165-169.
31. Rege NN, Thatte UM, Dahanukar SA. 1999. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 13: 275-291.
32. Saini MR, Kumar S, Jagetia GC, Saini N. 1984a. Effect of Liv. 52 against radiation sickness and mortality. Ind Pract 37: 1133-1138.
33. Saini MR, Kumar S, Jagetia GC, Saini N. 1984b. Liv. 52 protection against late effects of mammalian spleen. Ind Drugs 21: 374-376.
34. Saini MR, Kumar S, Uma Devi P, Saini N. 1985. Whole body radiation-induced damage to the peripheral blood and protection by Liv. 52. Radiobiol Radiother 26: 487-493.
35. Saini MR, Saini N. 1985. Gamma ray radiation-induced histological liver damage and protection by Liv. 52. Radiobiol Radiother 26: 379-385.
36. Sarkar SR, Singh LR, Uniyal BP, Bhatnagar VS. 1989. Radioprotective effect of Liv. 52 and tissue reduced glutathione (GSH) in experimental rats. Probe 28: 191-195.
37. Sarma L, Tiku AB, Kesavan PC, Ogaki M. 1993. Evaluation of radioprotective action of mutant (E-25) form of Chlorella vulgaris in mice. J Radiat Res 34: 277-284.
38. Satyavati GV, Gupta AK, Tandon N. 1987. Medicinal plants of India. Indian Council of Medical Research, New Delhi, India 2: 230-239.
39. Saxena A, Goyal PK. 1998. Radioresponse of intestinal epithelium in swiss albino mice and its modification by Liv. 52. Proceedings of the International Conference on radiation biology: DNA Damage, Repair and Carcinogenesis; 56.
40. Shah LP. 1992. An open clinical trial of mentat in hyperkinetic children. Probe 4: 125-128.
41. Sharada AC, Solomon FE, Uma Devi P. 1993. Toxicity of Withania somnifera root extract in rats and mice. Int J Pharmacog 31: 205-212.
42. Singh SP, Abraham SK, Kesavan PC. 1995a. In vivo radioprotection with garlic extract. Mutat Res 345: 147-153.
43. Singh SP, Ashu B, Tiku AB, Kesavan PC. 1995b. Post-exposure radioprotection by Chlorella vulgaris. Ind J Exp Biol 33: 612-615.
44. Suresh K, Vasudevan DM. 1994. Augmentation of murine natural killer cell and antibody dependent cytotoxicity activities by Phyllanthus emblica, a new immunomodulator. J Ethanopharmacol 44: 55-60.
45. Sweeney TR. 1979. A Survey of Compounds from the Antiradiation Drug Development Program of the US Army Medical Research and Development Command. Government Printing Office: Washington, DC; 308-318.
46. Thali S, Thatte U, Dahanukar SA. 1998. The potential of Boerrhavia diffusa in radiation induced haemopoietic injury. Amala Res Bull 18: 20-22.
47. Thomson JF. 1962. Radiation Protection in Mammals. Reinhold publishing Corp: New York.
48. Turrisi AT, Klingerman MM, Glover DJ, et al. 1983. Experience with phase I trials of WR-2721 preceding radiation therapy. In Radioprotectors and Anticarcinogens: Nygaard OF, Simic MG (eds). Academic Press: New York; 681-694.
49. Uma-Devi P, Ganasoundari A. 1999. Modulation of Glutathione and antioxidant enzymes by Ocimum sanctum and its role in protection against radiation injury. Ind J Exp Biol 37: 262-268.
50. Uma-Devi P, Kamath R, Rao BSS. 2000. Radioprotective effect of Phyllanthus niruri on mouse chromosome. Curr Sci 78: 1245-1247.
51. Verma A, Kulkarni SK. 1991. Effect of a herbal psychotropic preparation, BR-16A (mentat), on performance of mice on elevated plus-maze. Ind J Exp Biol 29: 1120-1123.
52. Warrier PK, Nambiar VPK, Ramankutty C. 1996. Indian medicinal plants. Orient Ionman limited Hyderabad, India 1-5.
53. Yuhas JM. 1980. Active and passive absorption kinetics as the basis for selective protection of normal tissue by s-2-(3-aminopropylamino) ethylphosphorothioic acid. Cancer Res 40: 1519-1524.
54. Zhang JS, Sigdestad CP, Gemmell MA, Grdina DJ. 1987. Modification of radiation response in mice by fractionated extracts of Panax ginseng. Radiat Res 112: 156-163.
55. Ziauddin M, Phansalkar N, Patki P, et al. 1996. Studies on the immunomodulatory effects of ashwagandha. J Ethnopharmacol 50: 69-76.