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Promise for millions of patients with Irritable Bowel Syndrome: Preliminary results of new clinical research at Novartis
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Novartis AG Press Release
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Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart
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338831; note
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338831 Comparison of tegaserod (HTF 919) and its main human metabolite with cisapride and erythromycin on cardiac repolarization in the isolated rabbit heart. Drici MD, Ebert SN, Wang WX, Rodrigue I, Liu XK, Whitfield BH, Woolsey RL J Cardiovasc Pharmacol 1999 34 1 82-88 Lack of effects of tegaserod on the QT interval.
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17
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Novartis R&D Investor Seminar, New York
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342937; Company World Wide Web 1999 Sep 21
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342937 Novartis R&D Investor Seminar, New York. Company World Wide Web 1999 Sep 21
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18
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Drug development pipeline: Prucalopride
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344287; October 21
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344287 Drug development pipeline: Prucalopride. Janssen Pharmaceutica NV Company Comunication 1999 October 21
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Janssen Pharmaceutica NV Company Comunication
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19
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Novartis' Zelmac (tegaserod) shows promising role in treating irritable bowel syndrome (IBS)
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344545; October 22; note
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344545 Novartis' Zelmac (tegaserod) shows promising role in treating irritable bowel syndrome (IBS). Novartis AG Press Release 1999 October 22 Press release summarizing phase III results.
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(1999)
Novartis AG Press Release
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20
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0141690599
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Zelmac (tegaserod) achieves fast, effective relief of irritable bowel syndrome in large international study
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350878; November 13; note
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350878 Zelmac (tegaserod) achieves fast, effective relief of irritable bowel syndrome in large international study. Novartis AG Press Release 1999 November 13 Press release summarizing phase III results.
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0033345899
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Effect of meal timing not critical for the pharmacokinetics of tegaserod (HTF 919)
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361833; note
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361833 Effect of meal timing not critical for the pharmacokinetics of tegaserod (HTF 919). Zhou H, Khalilieh S, Lau H, Guerret M, Osborne S, Alladina L, Laurent AL, McLeod JF J Clin Pharmacol 1999 39 9 911-919 Clinical pharmacokinetics of tegaserod.
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McLeod, J.F.8
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24
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0032898064
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4 receptor agonist, following oral and intravenous administration
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361834; note
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4 receptor agonist, following oral and intravenous administration. Appel-Dingemanse S, Lemarechal MO, Kumle A, Hubert M, Legangneux E Br J Clin Pharmacol 1999 47 5 483-491 Clinical pharmacokinetics of tegaserod.
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25
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0141802213
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Zelmac (tegaserod) granted priority review by FDA for the treatment of irritable bowel syndrome
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362853; Sep 21
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362853 Zelmac (tegaserod) granted priority review by FDA for the treatment of irritable bowel syndrome. Novartis AG Press Release 1999 Sep 21
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(1999)
Novartis AG Press Release
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27
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0141467400
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4 receptor partial agonist tegaserod (HTF 919) improves abdominal bloating and altered stool consistency in IBS
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4 receptor partial agonist tegaserod (HTF 919) improves abdominal bloating and altered stool consistency in IBS. Krumholz S, Tanghe J, Schmitt C, Heggland J, Shi Y, Ruegg PC Eur Gastroenterol Week 1999 November 17 Long-term data from 12-month open study.
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Eur Gastroenterol Week
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Krumholz, S.1
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28
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0141467398
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Short- and long-term safety and tolerability of tegaserod (HTF 919) in patients with irritable bowel syndrome (IBS)
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364540; November 16; note
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364540 Short- and long-term safety and tolerability of tegaserod (HTF 919) in patients with irritable bowel syndrome (IBS). Whorwell P, Muller-Lissner S, Langaker KJ, Wald A, Pruitt R, Ruegg P Eur Gastroenterol Week 1999 November 16 Phase III efficacy data.
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Whorwell, P.1
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29
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0001394241
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Effects of tegaserod (HTF 919) on gastrointestinal motility and transit in awake rats
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364458; Abs 2100; note
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30
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0007608640
-
Similar pharmacokinetics of tegaserod (HTF 919) in patients with constipation- and diarrhea-predominant irritable bowel syndrome
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372223; Abs 5340; note
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372223 Similar pharmacokinetics of tegaserod (HTF 919) in patients with constipation- and diarrhea-predominant irritable bowel syndrome. Appel-Dingemanse S, Rawls J, Heggland J, Campestrini J, Sechaud R Gastroenterology 2000 118 4 Suppl 2 (Pt 2) Abs 5340 Comparative pharmacokinetics in constipation-dependent and diarrhea-dependent IBS patients.
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Appel-Dingemanse, S.1
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Sechaud, R.5
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31
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0000444412
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Effect of gastric pH on plasma concentrations of tegaserod (HTF 919) and its major metabolite in healthy subjects
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372467; Abs 5538; note
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372467 Effect of gastric pH on plasma concentrations of tegaserod (HTF 919) and its major metabolite in healthy subjects. Zhou H, Khaliliens S, Campestrini J, Appel-Dingemanse S, Lachman L, McLeod JF Gastroenterology 2000 118 4 Suppl 2 Abs 5538 The metabolism of tegaserod is increased at low pH.
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32
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0008118173
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Two clinical trials of irritable bowel syndrome with tegaserod (HTF 919) validate global relief measure
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372970; March 10-14 Abs 442; note
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372970 Two clinical trials of irritable bowel syndrome with tegaserod (HTF 919) validate global relief measure. Lefkowitz M, Ruegg P, Dunger-Baldauf C, Shi Y J Gastroenterol Hepatol 2000 15 March 10-14 Abs 442 Subjective analysis of two phase III trials.
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Lefkowitz, M.1
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0038760661
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Tegaserod pharmacokinetics (PK) are similar in different types of irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD)
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372973; March 10-14 Abs 443; note
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372973 Tegaserod pharmacokinetics (PK) are similar in different types of irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Appel-Dingemanse S, Campestrini J, Rawls J, Sechaud R J Gastroenterol Hepatol 2000 15 March 10-14 Abs 443 Comparative pharmacokinetics in constipation-dependent and diarrhea-dependent IBS patients with GERD patients.
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Appel-Dingemanse, S.1
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34
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0001030304
-
4 receptor partial agonist tegaserod (HTF 919) accelerates upper and lower gastrointestinal (GI) transit
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372974; March 10-14 Abs 441; note
-
4 receptor partial agonist tegaserod (HTF 919) accelerates upper and lower gastrointestinal (GI) transit. Degen L, Matzinger D, Merz M, Appel-Dingemanse S, Maecke H, Beglinger C J Gastroenterol Hepatol 2000 15 March 10-14 Abs 441 Comparative efficacy of intravenous and oral dosing in man.
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The effects of tegaserod (HTF 919) on oesophageal acid exposure in gastro-oesophageal reflux disease
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36
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0001787087
-
4 receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat
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408788; Abs 27; note
-
4 receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat. Hicks GA, Clayton NM, Gaskin PJ, Kirkup AJ, Su X, Joshi S, Friedrich A, Connor HE, Cox B, Grundy D, Gerbhart GF Gastroenterology 2001 120 5 (Suppl 1) Abs 27 In vivo comparison with prucalopride.
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37
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0002706504
-
Tegaserod provides relief of symptoms in female patients with irritable bowel syndrome (IBS) suffering from abdominal pain and discomfort, bloating and constipation
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408819; Abs 104; note
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408819 Tegaserod provides relief of symptoms in female patients with irritable bowel syndrome (IBS) suffering from abdominal pain and discomfort, bloating and constipation. Leftkowitz M, Ligozio G, Glebas K, Heggland JE, Ruegg PC Gastroenterology 2001 120 5 (Suppl 1) Abs 104 Results of a 12-week phase III study in 1519 patients.
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0000164178
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4 receptor partial agonist, devoid of significant electrocardiographic effects
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410915; Abs 3257
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4 receptor partial agonist, devoid of significant electrocardiographic effects. Rueegg P, Baldauf CD, Dingemanse SA, Lefkowitz M, Morganroth J Gastroenterology 2001 120 5 Suppl 1 Abs 3257
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0141802211
-
Early effect of tegaserod predicts continued efficacy in treatment of constipation predominant irritable bowel syndrome
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410922; Abs 3259; note
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410922 Early effect of tegaserod predicts continued efficacy in treatment of constipation predominant irritable bowel syndrome. Muller-Lissner S, Lefkowitz M, Shi Y, Nault B, Heggland J, Glebas K, Ruegg PC Gastroenterology 120 5 (Suppl 1) Abs 3259 Analysis of phase III studies to assess onset of therapeutic effects.
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40
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0034089045
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Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome
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416098; note
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416098 Tegaserod accelerates orocecal transit in patients with constipation-predominant irritable bowel syndrome. Prather CM, Camilleri M, Zinsmeister AR, McKinzie S, Thomforde G Gastroenterology 2000 10 5 463-468 The stimulation of human orocecal transport by tegaserod.
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0141690596
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Novartis launches irritable bowel syndrome treatment Zelmac in first market, Mexico
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416879; July 25
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416879 Novartis launches irritable bowel syndrome treatment Zelmac in first market, Mexico. Novartis AG Press Release 2001 July 25
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Novartis AG Press Release
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Novartis reports sustained growth in first half of 2001
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419544 Novartis reports sustained growth in first half of 2001. Novartis AG Press Release 2001 Aug 16
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Merrill Lynch Capital Markets
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44
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0141467339
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Rome I versus Rome II: Overlap in patients enrolled in tegaserod phase III clinical trials for irritable bowel syndrome (IBS)
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422835; Abs 1472; note
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422835 Rome I versus Rome II: Overlap in patients enrolled in tegaserod phase III clinical trials for irritable bowel syndrome (IBS). Nault B, Sam S, Heggland JE, Gohari S, Ligozio G, D'Agay L Gastroenterology 2001 120 Abs 1472 Assessment of the impact of using Rome 2 criteria on the outcome of tegaserod phase III trials.
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428551 Tegaserod, a 5-HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Muller Lissner SA, Fumagalli I, Bardhan KD, Pace F, Pecher E, Nault B, Ruegg P Aliment Pharmacol Ther 2001 15 10 1655-1666
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Drug development pipeline: Tegaserod
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441515 Drug development pipeline: Tegaserod. Novartis Pharma AG Company Communication 2001 October 12
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Maecke, H.7
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