Mechanism of cell death induced by the novel enzyme-prodrug combination, nitroreductase/CB1954, and identification of synergism with 5-fluorouracil

British Journal of Cancer

Volumn 89, Issue 5, 2003, Pages 944-950

  Palmer, D H ^a   Milner, A E ^a   Kerr, D J ^a,b   Young, L S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

5 fluorouracil; Apoptosis; CBI954; Nitroreductase; Synergy; VDEPT

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; ADENOVIRUS VECTOR; CASPASE; CASPASE INHIBITOR; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GEMCITABINE; NITROREDUCTASE; PACLITAXEL; PRODRUG; TOPOTECAN;

APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CANCER CHEMOTHERAPY; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG EFFECT; FEMALE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; PRIORITY JOURNAL; VIRUS REPLICATION;

ADENOVIRIDAE; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; AZIRIDINES; BLOTTING, WESTERN; CASPASES; DRUG SYNERGISM; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; FLUOROURACIL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; NITROREDUCTASES; OVARIAN NEOPLASMS; PRODRUGS; TUMOR CELLS, CULTURED;

EID: 0141507043     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601211     Document Type: Article

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