Coenzyme Q as a generator of reactive oxygen metabolites

Coenzyme Q: Molecular Mechanisms in Health and Disease

Volumn , Issue , 2000, Pages 163-180

  Nohl, Hans ^a   Gille, Lars ^a   Kozlov, Andrey V ^a   Staniek, Katrin ^a  

^a UNIVERSITY OF VETERINARY MEDICINE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0141501399     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (20)

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2. Trumpower, B. L. and Simmons, Z., Diminished inhibition of mitochondrial electron transfer from succinate to cytochrome c by thenoyltrifluoroacetone induced by antimycin, J. Biol. Chem., 254, 4608, 1979.
3. Trumpower, B. L., The protonmotive Q cycle, J. Biol. Chem., 265, 11409, 1990.
4. Nohl, H., Gille, L., and Staniek, K., The biochemical, pathophysiological and medical aspects of ubiquinone function, Ann. N.Y. Acad. Sci., 854, 394, 1998.
5. Mitchell, P., Protonmotive redox mechanism of the cytochrome b-c1 complex in the respiratory chain: protonmotive ubiquinone cycle, FEBS Lett., 56, 1, 1975.
6. Brandt, U., Energy conservation by bifurcated electron-transfer in the cytochrome-bc1 complex, Biochim. Biophys. Acta, 1275, 41, 1996.
7. Brandt, U., Bifurcated ubihydroquinone oxidation in the cytochrome bc1 complex by proton-gated charge transfer, FEBS Lett., 387, 1, 1996.
8. Brandt, U., Proton-translocation by membrane-bound NADH: ubiquinone-oxidoreductase (complex I) through redox-gated ligand conduction, Biochim. Biophys. Acta, 1318, 79, 1997.
9. Nohl, H. and Stolze, K., Ubisemiquinones of the Mitochondrial Respiratory Chain do not Interact with Molecular Oxygen, Free Radic. Res. Commun., 16, 409, 1992.
10. Schönheit, K., Gille, L., and Nohl, H., Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria, Biochim. Biophys. Acta, 1271, 335-342, 1995.
11. 2 detection from intact mitochondria as a measure for one-electron reduction of dioxygen requires a non-invasive assay system, in preparation.
12. Ohnishi, T., Schägger, H., Meinhardt, S. W., LoBrutto, R., Link, T. A., and von Jagow, G., Spatial organization of the redox active centers in the bovine heart ubiquinol-cytochrome coxidoreductase. J. Biol. Chem, 264, 735, 1989.
13. Nohl, H., A novel superoxide radical generator in heart mitochondria, FEBS Lett., 214, 269, 1987.
14. Nohl, H., Demonstration of the existence of an organo-specific NADH dehydrogenase in heart mitochondria, Eur J. Biochem., 169, 585, 1987.
15. Nohl, H., Gille, L., Schoenheit, K., and Liu, Y., Conditions allowing redox-cycling ubisemiquinone in mitochondria to establish a direct redox couple with molecular oxygen, Free Radic. Biol. Med., 20, 207, 1996.
16. Nohl, H. and Gille, L. unpublished data. 1999.
17. Nohl, H. and Jordan, W., The metabolic fate of mitochondrial hydrogen peroxide. Eur. J. Biochem., 111, 203, 1980.
18. Nohl, H. and Jordan, W., The biochemical role of ubiquinone and ubiquinone-derivatives in the generation of hydroxyl-radicals from hydrogen peroxide, in Oxygen Radicals in Chemistry and Biology, Bors, W., Saran, M., and Tait, D., Eds., De Gruyter, New York, 1984, 155.
19. Gille, L. and Nohl, H., Redox-function of ubiquinone in lysosomes, presented at SFRR (Europe) Summer Meeting, Dresden, July 2 to 5, 1999, OP53. Nohl, H., Gille, L. Chapter: The Role of Coenzyme Q in Lysosomes, CoenzymeQ: From molecular mechanisms to Nutrition and Health, Kagan, V and Quinn, P. J., eds., CRC Press, Boca Raton, FL, 2000.
20. Nohl, H., Gille, L., and Kozlov, A. V, Antioxidant-derived prooxidant formation from ubiquinol, Free Radic. Biol. Med., 25, 666, 1998.