Issues in subgroup analyses and meta-analyses of clinical trials

Journal of Cardiovascular Electrophysiology

Volumn 14, Issue 9 SUPPL., 2003, Pages

  Bigger, J Thomas ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Data pooling; Meta analysis; Randomized clinical trials; Subgroup analysis

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; DILTIAZEM; HORMONE;

CARDIOVASCULAR DISEASE; CLINICAL RESEARCH; CLINICAL TRIAL; CONFERENCE PAPER; DATA ANALYSIS; DRUG RESEARCH; HORMONE SUBSTITUTION; HUMAN; INFORMATION PROCESSING; INTERMETHOD COMPARISON; LUNG CONGESTION; META ANALYSIS; PHYSICIAN; PREDICTION; PRIORITY JOURNAL; RELIABILITY; RISK FACTOR; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0141501386     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8167.14.s9.1.x     Document Type: Conference Paper

References (9)

1. Ridker PM, Buring JE, Cook NR, Rifai N: C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events. An 8-year follow-up of 14,719 initially healthy American women. Circulation 2003;107:391-397.
2. The Multicenter Diltiazem Postinfarction Trial Research Group: The effect of diltiazem on mortality and reinfarction after myocardial infarction. N Engl J Med 1988;319:385-392.
3. Sleight P: Subgroup analysis in clinical trials: Fun to look at - but don't believe them. Curr Control Trials Cardiovasc Med 2000;1:25-27.
4. DeMets DL, Califf RM: Lessons learned from recent cardiovascular clinical trials: Part I. Circulation 2002;106:746-751.
5. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group: Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. Lancet 1988;ii:349-360.
6. Whitehead A, Whitehead J: A general parametric approach to the metaanalysis of randomized clinical trials. Stat Med 1991;10:1665-1677.
7. Egger M, Davey Smith G, Phillips AN: Meta-analysis: principles and procedures. Br Med J 1997;315:1533-1537.
8. Lievre M, Cucherat M, Leizorovicz A: Pooling, meta-analysis, and the evaluation of drug safety. Curr Control Trials Cardiovasc Med 2002;3:6-9.
9. Julious SA, Mullee MA: Confounding and the Simpson's paradox. Br Med J 1994;309:1480-1481.