Review of prehospital sodium bicarbonate use for cyclic antidepressant overdose

Emergency Medicine Journal

Volumn 20, Issue 5, 2003, Pages 483-486

  Calkins, T ^a   Chan, T C ^a   Clark, R F ^a   Stepanski, B ^b   Vilke, G M ^a  

^a UCSD MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BICARBONATE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; DATA BASE; DEMOGRAPHY; DOSE RESPONSE; DRUG INDICATION; DRUG OVERDOSE; DRUG USE; FEMALE; HEALTH STATUS; HEART ARRHYTHMIA; HOSPITAL; HUMAN; HYPOTENSION; MALE; MEDICAL RECORD; NEUROLOGIC DISEASE; PARAMEDICAL PERSONNEL; PHYSICIAN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEIZURE;

EID: 0141496062     PISSN: 13510622     EISSN: None     Source Type: Journal    
DOI: 10.1136/emj.20.5.483     Document Type: Article

References (12)

1. Litovitz TL, Klein-Schwartz W, Caravati EM, et al. 1998 annual report of the American association of poison control centers toxic exposure surveillance system. Am J Emerg Med 1999;17:435-87.
2. Callaham M, Kassel D. Epidemiology of fatal tricyclic antidepressant ingestion: Implications for management. Ann Emerg Med 1985;14:1-9.
3. Walter FG. Antidepressants and monoamine oxidase inhibitors. Emergency Medicine: Concepts and Clinical Practice. 4th edn. In: Rosen P, ed. 1998:1325-31.
4. Mills KC. Tricyclic antidepressants. In: Tintinalli JE, ed. Emergency Medicine: A Comprehensive Study Guide. 4th edn. New York, NY: McGraw Hill, 1996:740-4.
5. Aks S. Tricyclic antidepressant, poisoning. In: Rosen R, ed. The 5 Minute Emergency Medicine Consult. 1st edn. Philadelphia, PA: Lippincott Williams and Wilkins, 1999:1158-9.
6. Newton EH, Shih RD, Hoffman RS. Cyclic antidepressant overdose: A review of current management strategies. Am J Emerg Med 1994;12:376-9.
7. Sasyniuk B, Jhamandas V. Mechanism of reversal of toxic amitriptyline on cardiac purkinje fibers by sodium bicarbonate. J Pharmacol Experimental Ther 1984;231:387-94.
8. Pentel P, Benowitz N. Efficacy and mechanism of action of sodium bicarbonate in the treatment of desipramine toxicity in rats. J Pharmacol Experimental Ther 1984;230:12-20.
9. Nattel S, Keable H, Sasyniuk BI. Experimental amitriptyline intoxication: Electrophysiologic manifestations and management. J Cardiovasc Pharmacol 1984;6:83-9.
10. Hedges JR, Baker PB, Jassett JJ, et al. Bicarbonate therapy for the cardiovascular toxicity of amitriptyline in an animal model. J Emerg Med 1985;3:253-60.
11. Hoffman JR, Votey SR, Bayer M, et al. Effect of hypertonic sodium bicarbonate in the treatment of moderate to severe cyclic antidepressant overdose. Am J Emerg Med 1993;11:336-41.
12. Liebelt EL, Ulrich A, Francis PD, et al. Serial electrocardiogram changes in acute tricyclic antidepressant overdoses. Crit Care Med 1997;25:1712-26.