Iron Transport and Signaling in Plants

Annual Review of Plant Biology

Volumn 54, Issue , 2003, Pages 183-206

  Curie, Catherine ^a   Briat, Jean François ^a  

^a INRA   (France)

Author keywords

Homeostasis; Long range signaling; Nutrition

Indexed keywords

IRON;

CELL ORGANELLE; METABOLISM; PHYSIOLOGY; PLANT; PLANT PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; IRON; ORGANELLES; PLANT COMPONENTS; PLANT PHYSIOLOGY; PLANTS; SIGNAL TRANSDUCTION;

EID: 0141489216     PISSN: 15435008     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.arplant.54.031902.135018     Document Type: Review

References (105)

1. Askwith CC, de Silva D, Kaplan J. 1996. Molecular biology of iron acquisition in Saccharomyces cerevisiae. Mol. Microbiol. 20:27-34
2. Askwith C, Eide D, Van HA, Bernard PS, Li L, et al. 1994. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76:403-10
3. Bagnaresi P, Mazars-Marty D, Pupillo P, Marty F, Briat JF. 2000. Tonoplast subcellular localization of maize cytochrome b5 reductases. Plant J. 24:645-54
4. Basso B, Bagnaresi P, Bracale M, Soave C. 1994. The yellow-stripe-1 and -3 mutants of maize: nutritional and biochemical studies. Maydica 39:97-105
5. Becker R, Fritz E, Manteuffel R. 1995. Subcellular localization and characterization of excessive iron in the nicotianamine-less tomato mutant chloronerva. Plant Physiol. 108:269-75
6. Bienfait HF, Lubberding HJ, Heutink P, Linder L, Visser J, et al. 1989. Rhizosphere acidification by iron deficient bean plants: the role of trace amounts of divalent metal ions. Plant Physiol. 90:359-64
7. Briat J-F. 1999. Plant ferritin and human iron deficiency. Nat. Biotechnol. 17: 621
8. Briat J-F, Fobis-Loisy I, Grignon N, Lobréaux S, Pascal N, et al. 1995. Cellular and molecular aspects of iron metabolism in plants. Biol. Cell 84:69-81
9. Briat J-F, Lobréaux, S. 1997. Iron transport and storage in plants. Trends Plant Sci. 2:187-93
10. Briat J-F, Lobréaux S, Grignon N, Vansuyt G. 1999. Regulation of plant ferritin synthesis: how and why. Cell. Mol. Life Sci. 56:155-66
11. Bruggemann W, Maas-Kantel K, Moog PR. 1993. Iron uptake by leaf mesophyll cells: the role of the plasma membrane-bound ferric-chelate reductase. Planta 190:151-55
12. Bughio N, Takahashi M, Yoshimura E, Nishizawa NK, Mori S. 1997. Light-dependent iron transport into isolated barley chloroplasts. Plant Cell Physiol. 38:101-5
13. Casas C, Aldea M, Espinet C, Gallego C, Gil R, Herrero E. 1997. The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae. Yeast 13:621-37
14. Cataldo DA, McFadden KM, Garland TR, Wildung RE. 1988. Organic constituents and complexation of nickel (II), iron (III), cadmium (II), and plutonium (IV) in soybean xylem exudates. Plant Physiol. 86:734-39
15. Cohen A, Nelson H, Nelson N. 2000. The family of SMF metal ion transporters in yeast cells. J. Biol. Chem. 275:33388-94
16. Cohen CK, Fox TC, Garvin DF, Kochian LV. 1998. The role of iron-deficiency stress responses in stimulating heavy-metal transport in plants. Plant Physiol. 116:1063-72
17. Connolly EL, Fett JP, Guerinot ML. 2002. Expression of the IRT1 metal transporter is controlled by metals at the levels of transcript and protein accumulation. Plant Cell 14:1347-57
18. Curie C, Alonso JM, Le Jean M, Ecker JR, Briat JF. 2000. Involvement of NRAMP1 from Arabidopsis thaliana in iron transport. Biochem. J. 347:749-55
19. Curie C, Panaviene Z, Loulergue C, Dellaporta SL, Briat JF, Walker EL. 2001. Maize yellow stripe 1 encodes a membrane protein directly involved in Fe(III) uptake. Nature 409:346-49
20. Dancis A, Klausner RD, Hinnebusch AG, Barriocanal JG. 1990. Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:2294-301
21. De Silva DM, Askwith CC, Eide DJ, Kaplan J. 1995. The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase. J. Biol. Chem. 270:1098-101
22. Delhaize E. 1996. A metal-accumulator mutant of Arabidopsis thaliana. Plant Physiol. 111:849-55
23. Dix DR, Bridgham JT, Broderius MA, Byersdorfer CA, Eide DJ. 1994. The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae. J. Biol. Chem. 269:26092-99
24. Dix DR, Bridgham J, Broderius M, Eide DJ. 1997. Characterization of the FET4 protein of yeast. Evidence for a direct role in the transport of iron. J. Biol. Chem. 272:11770-77
25. Eckhardt U, Mas Marques A, Buckhout TJ. 2001. Two iron-regulated cation transporters from tomato complement metal uptake-deficient yeast mutants. Plant Mol. Biol. 45:437-48
26. Eide DJ. 1998. The molecular biology of metal ion transport in Saccharomyces cerevisiae. Annu. Rev. Nutr. 18:441-69
27. Eide DJ, Broderius M, Fett J, Guerinot ML. 1996. A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Proc. Natl. Acad. Sci. USA 93:5624-28
28. Eide DJ, Davis-Kaplan S, Jordan I, Sipe D, Kaplan J. 1992. Regulation of iron uptake in Saccharomyces cerevisiae. The ferrireductase and Fe(II) transporter are regulated independently. J. Biol. Chem. 267:20774-81
29. Fox TM, Guerinot ML. 1998. Molecular biology of cation transport in plants. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49:669-96
30. Georgatsou E, Alexandraki D. 1994. Two distinctly regulated genes are required for ferric reduction, the first step of iron uptake in Saccharomyces cerevisiae. Mol. Cell. Biol. 14:3065-73
31. Gitan RS, Eide DJ. 2000. Zinc-regulated ubiquitin conjugation signals endocytosis of the yeast ZRT1 zinc transporter. Biochem. J. 346:329-36
32. Grusak MA. 1995. Whole-root iron(III)-reductase activity throughout the life cycle of iron-grown Pisum sativum L. (Fabaceae): relevance to the iron nutrition of developing seeds. Planta 197:111-17
33. Grusak MA, Pezeshgi S. 1996. Shoot-to-root signal transmission regulates root Fe(III) reductase activity in the dg1 mutant of pea. Plant Physiol. 110:329-34
34. Guerinot ML. 2000. The ZIP family of metal transporters. Biochim. Biophys. Acta 1465:190-98
35. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-88
36. Henriques R, Jasik J, Klein M, Martinoia E, Feller U, et al. 2002. Knock out of Arabidopsis metal transporter gene IRT1 results in iron deficiency accompanied by cell differentiation defects. Plant Mol. Biol. 50:587-97
37. Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S. 1999. Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores. Plant Physiol. 119:471-80
38. Himelblau E, Mira H, Lin SJ, Culotta VC, Penarrubia L, Amasino RM. 1998. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol. 117:1227-34
39. Hirayama T, Kieber JJ, Hirayama N, Kogan M, Guzman P, et al. 1999. RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis. Cell 97:383-93
40. Kispal G, Csere P, Prohl C, Lill R. 1999. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 18:3981-89
41. Klausner RD, Rouault TA, Harford JB. 1993. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72:19-28
42. Kobayashi T, Nakanishi H, Takahashi M, Kawasaki S, Nishizawa NK, Mori S. 2001. In vivo evidence that Ids3 from Hordeum vulgare encodes a dioxygenase that converts 2′-deoxymugineic acid to mugineic acid in transgenic rice. Planta 212:864-71
43. Korshunova YO, Eide DJ, Clark WG, Guerinot ML, Pakrasi HB. 1999. The IRT1 protein from Arabidopsis thaliana is a metal transporter with a broad substrate range. Plant Mol. Biol. 40:37-44
44. Krueger C, Berkowitz O, Stephan UW, Hell R. 2002. A metal-binding member of the late embryogenesis abundant protein family transports iron in the phloem of Ricinus communis L. J. Biol. Chem. 277:25062-69
45. La Fontaine S, Quinn J, Merchant S. 2002. Comparative analysis of copper and iron metabolism in photosynthetic eukaryotes vs. yeast and mammals. In Handbook of Copper, Pharmacology and Toxicology, pp. 481-502. Totowa, NJ: Humana Press
46. Li L, Chen OS, McVey Ward D, Kaplan J. 2001. CCC1 is a transporter that mediates vacuolar iron storage in yeast. J. Biol. Chem. 276:29515-19
47. Li L, Kaplan J. 1997. Characterization of two homologous yeast genes that encode mitochondrial iron transporters. J. Biol. Chem. 272:28485-93
48. Lill R, Kispal G. 2000. Maturation of cellular Fe-S proteins: an essential function of mitochondria. Trends Biochem. Sci. 25:352-56
49. Ling H-Q, Bauer P, Keller B, Ganal M. 2002. The tomato fer gene encoding a bHLH protein controls iron uptake responses in roots. Proc. Natl. Acad. Sci. USA 99:13938-43
50. Ling H-Q, Koch G, Baumlein H, Ganal MW. 1999. Map-based cloning of chloronerva, a gene involved in iron uptake of higher plants encoding nicotianamine synthase. Proc. Natl. Acad. Sci. USA 96:7098-103
51. Ling H-Q, Pich A, Scholz G, Ganal MW. 1996. Genetic analysis of two tomato mutants affected in the regulation of iron metabolism. Mol. Gen. Genet. 252:87-92
52. Maas FM, van der Wetering DAM, van Beusichem ML, Bienfait HF. 1988. Characterization of phloem iron and its possible role in the regulation of Fe-efficiency reactions. Plant Physiol. 87:167-71
53. Marentes E, Grusak MA. 1998. Iron transport and storage within the seed coat and embryo of developing seeds of pea (Pisum sativum L.). Seed Sci. Res. 8:367-75
54. Marschner H, Röhmeld V. 1994. Strategies of plants for acquisition of iron. Plant Soil 165:375-88
55. McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, et al. 2000. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5:299-309
56. Mira H, Martinez-Garcia F, Penarrubia L. 2001. Evidence for the plant-specific intercellular transport of the Arabidopsis copper chaperone CCH. Plant J. 25:521-28
57. Moog PR, Brüggemann W. 1995. Iron reductase systems on the plant plasma membrane - a review. In Iron Nutrition in Soils and Plants, ed. J Abadia, pp. 343-62. Dordrecht: Kluwer. 397 pp.
58. Mori S. 1999. Iron acquisition by plants. Curr. Opin. Plant Biol. 2:250-53
59. Murgia I, Delledonne M, Soave C. 2002. Nitric oxide mediates iron-induced ferritin accumulation in Arabidopsis. Plant J. 30:521-28
60. Nakanishi H, Yamaguchi H, Sasakuma T, Nishizawa NK, Mori S. 2000. Two dioxygenase genes, Ids3 and Ids2, from Hordeum vulgare are involved in the biosynthesis of mugineic acid family phytosiderophores. Plant Mol. Biol. 44:199-207
61. Negishi T, Nakanishi H, Yazaki J, Kishimoto N, Fujii F, et al. 2002. cDNA microarray analysis of gene expression during Fe-deficiency stress in barley suggests that polar transport of vesicles is implicated in phytosiderophore secretion in Fe-deficient barley roots. Plant J. 30:83-94
62. Neilands JB. 1995. Siderophores: structure and function of microbial iron transport compounds. J. Biol. Chem. 270:26723-26
63. Nishizawa N, Mori S. 1987. The particular vesicle appearing in barley root cells and its relation to mugineic acid secretion. J. Plant Nutr. 10:1013-20
64. Petit JM, van Wuytswinkel O, Briat JF, Lobréaux S. 2001. Characterization of an iron-dependent regulatory sequence involved in the transcriptional control of AtFer1 and ZmFer1 plant ferritin genes by iron. J. Biol. Chem. 276:5584-90
65. Pich A, Manteuffel R, Hillmer S, Scholz G, Schmidt W. 2001. Fe homeostasis in plant cells: does nicotianamine play multiple roles in the regulation of cytoplasmic Fe concentration? Planta 213:967-76
66. Pich A, Scholz G, Stephan UW. 1994. Iron-dependent changes of heavy metals, nicotianamine, and citrate in different plant organs and in the xylem exudate of two tomato genotypes. Nicotianamine as possible copper translocator. Plant Soil 165:189-96
67. Portnoy ME, Jensen LT, Culotta VC. 2002. The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem. J. 362:119-24
68. Portnoy ME, Liu XF, Culotta VC. 2000. Saccharomyces cerevisiae expresses three functionally distinct homologues of the Nramp family of metal transporters. Mol. Cell. Biol. 20:7893-902
69. Robinson NJ, Procter CM, Connolly EL, Guerinot ML. 1999. A ferric-chelate reductase for iron uptake from soils. Nature 397:694-97
70. Rogers EE, Eide DJ, Guerinot ML. 2000. Altered selectivity in an Arabidopsis metal transporter. Proc. Natl. Acad. Sci. USA 97:12356-60
71. Rogers EE, Guerinot ML. 2002. FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis. Plant Cell 14:1787-99
72. Romera FJ, Alcantara E. 1994. Iron-deficiency stress responses in cucumber (Cucumis sativus L.) roots. A possible role for ethylene. Plant Physiol. 105:1133-38
73. Romera FJ, Alcantara E, Diaz de la Guardia M. 1992. Role of roots and shoots in the regulation of the Fe efficiency responses in sunflower and cucumber. Physiol. Plant. 85:141-46
74. Sakaguchi T, Nishizawa NK, Nakanishi H, Yoshimura E, Mori S. 1999. The role of potassium in the secretion of mugineic acids family phytosiderophores from iron-deficient barley roots. Plant Soil 215:221-27
75. Schmidke I, Kruger C, Frommichen R, Scholz G, Stephan U. 1999. Phloem loading and transport characteristics of iron in interaction with plant-endogenous ligands in castor bean seedlings. Physiol. Plant. 106:82-89
76. Schmidt W, Schikora A. 2001. Different pathways are involved in phosphate and iron stress-induced alterations of root epidermal cell development. Plant Physiol. 125:2078-84
77. Schmidt W, Schuck C. 1996. Pyridine nucleotide pool size changes in iron-deficient Plantago lanceolata roots during reduction of external oxidants. Physiol. Plant. 98:215-21
78. Schmidt W, Tittel J, Schikora A. 2000. Role of hormones in the induction of iron deficiency responses in Arabidopsis roots. Plant Physiol. 122:1109-18
79. Shingles R, North M, McCarty RE. 2002. Ferrous ion transport across chloroplast inner envelope membranes. Plant Physiol. 128:1022-30
80. Stearman R, Yuan DS, Yamaguchi-Iwai Y, Klausner RD, Dancis A. 1996. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science 271:1552-57
81. Stephan U, Schmidke I, Pich A. 1994. Phloem translocation of Fe, Cu, Mn and Zn in Ricinus seedlings in relation to the concentration of nicotianamine, an endogenous chelator of divalent metal ions, in different seedling parts. Plant Soil 165:181-88
82. Stephan UW, Grun M. 1989. Physiological disorders of the nicotianamine-auxotroph tomato mutant chloronerva at different levels of iron nutrition. II. Iron deficiency response and heavy metal metabolism. Biochem. Physiol. Pflanz. 185:3-4
83. Stephan UW, Scholz G. 1993. Nicotianamine: mediator of transport of iron and heavy metals in the phloem. Physiol. Plant. 88:522-29
84. Takagi SI, Nomoto K, Takemoto T. 1984. Physiological aspect of mugineic acid, a possible phytosiderophore of graminaceous plants. J. Plant Nutr. 7:1-5
85. Takahashi M, Nakanishi H, Kawasaki S, Nishizawa NK, Mori S. 2001. Enhanced tolerance of rice to low iron availability in alkaline soils using barley nicotianamine aminotransferase genes. Nat. Biotechnol. 19:466-69
86. Takahashi M, Yamaguchi H, Nakanishi H, Shioiri T, Nishizawa NK, Mori S. 1999. Cloning two genes for nicotianamine aminotransferase, a critical enzyme in iron acquisition (Strategy II) in graminaceous plants. Plant Physiol. 121:947-56
87. Thomine S, Lelièvre F, Debarbieux E, Schroeder J, Barbier-Brygoo H. 2002. At-NRAMP3 encodes a vacuolar metal transporter induced by iron deficiency that down regulates iron acquisition mechanisms in Arabidopsis. Proc. Int. Symp. Iron Nutr. Interact. Plants, 11th, Abstr. 126
88. Thomine S, Wang R, Ward JM, Crawford NM, Schroeder JI. 2000. Cadmium and iron transport by members of a plant metal transporter family in Arabidopsis with homology to Nramp genes. Proc. Natl. Acad. Sci. USA 97:4991-96
89. Urbanowski JL, Piper RC. 1999. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane. J. Biol. Chem. 274:38061-70
90. Varotto C, Maiwald D, Pesaresi P, Jahns P, Salamini F, Leister D. 2002. The metal ion transporter IRT1 is necessary for iron homeostasis and efficient photosynthesis in Arabidopsis thaliana. Plant J. 31:589-99
91. Vert G, Briat J-F, Curie C. 2001. Arabidopsis IRT2 gene encodes a root-periphery iron transporter. Plant J. 26: 181-89
92. Vert G, Grotz N, Dedaldechamp F, Gaymard F, Guerinot ML, et al. 2002. IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth. Plant Cell 14:1223-33
93. Vieira LM, Kaplan JC, Kahn A, Leroux A. 1995. Four new mutations in the NADH-cytochrome b5 reductase gene from patients with recessive congenital methemoglobinemia type II. Blood 85:2254-62
94. von Wiren N, Klair S, Bansal S, Briat J-F, Khodr H, et al. 1999. Nicotianamine chelates both FeIII and FeII. Implications for metal transport in plants. Plant Physiol. 119:1107-14
95. von Wiren N, Mori S, Marschner H, Romheld V. 1994. Iron inefficiency in maize mutant ys1 (Zea mays L. cv Yellow-Stripe) is caused by a defect in uptake of iron phytosiderophores. Plant Physiol. 106:71-77
96. Waters BM, Blevins DG, Eide DJ. 2002. Characterization of FRO1, a pea ferricchelate reductase involved in root iron acquisition. Plant Physiol. 129:85-94
97. Welch RM, LaRue TA. 1990. Physiological characteristics of Fe accumulation in the "bronze" mutant of Pisum sativum L., cv "Sparkle" E107 (brz brz). Plant Physiol. 93:723-29
98. Xoconostle-Cazares B, Ruiz-Medrano R, Lucas WJ. 2000. Proteolytic processing of CmPP36, a protein from the cytochrome b5 reductase family, is required for entry into the phloem translocation pathway. Plant J. 24:735-47
99. Yamaguchi-Iwai Y, Dancis A, Klausner RD. 1995. AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae. EMBO J. 14:1231-39
100. Yamaguchi-Iwai Y, Ueta R, Fukunaka A, Sasaki R. 2002. Subcellular localization of Aft1 transcription factor responds to iron status in Saccharomyces cerevisiae. J. Biol. Chem. 277:18914-18
101. Yen MR, Tseng YH, Saier MH Jr. 2001. Maize Yellow Stripe 1, an iron-phytosiderophore uptake transporter, is a member of the oligopeptide transporter (OPT) family. Microbiology 147:2881-83
102. Yi Y, Guerinot ML. 1996. Genetic evidence that induction of root Fe(III) chelate reductase activity is necessary for iron uptake under iron deficiency. Plant J. 10:835-44
103. Yun CW, Bauler M, Moore RE, Klebba PE, Philpott CC. 2001. The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. J. Biol. Chem. 276:10218-23
104. Yun CW, Ferea T, Rashford J, Ardon O, Brown PO, et al. 2000. Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake. J. Biol. Chem. 275:10709-15
105. Yun CW, Tiedeman JS, Moore RE, Philpott CC. 2000. Siderophore-iron uptake in Saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters. J. Biol. Chem. 275:16354-59