xylo-configured oligonucleotides (XNA, xylo nucleic acids): Synthesis and hybridization studies

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1147-1149

  Poopeiko, Nicolai E ^a   Dahl, Britta M ^b   Wengel, Jesper ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Hybridization; Oligonucleotides; XNA (xylo nucleic acids)

Indexed keywords

1 (2' DEOXY 2 FLUORO BETA DEXTRO XYLOFURANOSYL)THYMINE; 1 (2' DEOXY BETA DEXTRO XYLOFURANOSYL)THYMINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; NUCLEIC ACID; OLIGO(2' DEOXYXYLONUCLEOTIDE); OLIGONUCLEOTIDE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG; XYLONUCLEIC ACID; XYLONUCLEOSIDE;

BINDING AFFINITY; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; HYBRIDIZATION; NUCLEOTIDE METABOLISM; SYNTHESIS;

BASE SEQUENCE; DNA, COMPLEMENTARY; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDES; RNA, COMPLEMENTARY; THYMINE; XYLOSE;

EID: 0141484718     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022822     Document Type: Conference Paper

References (6)

1. Rosemeyer, H.; Seela, F. 1-(2′-Deoxy-β -D-xylofuranosyl)thymine building blocks for solid-phase synthesis and properties of oligo(2′-deoxyxylonucleotides). Helv. Chim. Acta. 1991, 74, 748 pp.
2. Seela, F.; Heckel, M.; Rosemeyer, H. Xylose-DNA containing the four natural bases. Helv. Chim. Acta. 1996, 79, 1451 pp.
3. Svendsen, M.L.; Wengel, J.; Dahl, O.; Kirpekar, F.; Roepstorff, P. Oligodeoxynucleotide analogues containing 3′-deoxy-3′ -C-threo-hydroxymethylthymidine: synthesis, hybridization properties and enzymatic stability. Tetrahedron 1993, 49 (11), 341 pp.
4. Rajwanshi, V.K.; Håkansson, A.E.; Kumar, R.; Wengel, J. High-affinity nucleic acid recognition using 'LNA' (locked nucleic acid, β-D-ribo configured LNA), 'xylo'-LNA' (β-D-xylo configured LNA) or α-L-LNA' α-L-ribo configured LNA). Chem. Commun. 1999, 2073 pp.
5. Wright, J.A.; Wilson, D.P.; Fox, J.J. Nucleosides. LXIV. Fluoro sugar analogs of arabinosyl- and xylosylcytosines. J. Med. Chem. 1970, 13, 269 pp.
6. Rajwanshi, V.K.; Håkansson, A.E.; Dahl, B.M.; Wengel, J. LNA stereoisomers: xylo-LNA (β-D-xylo configured locked nucleic acid) and α-L-LNA (α-L-ribo configured locked nucleic acid). Chem. Commun. 1999, 1395 pp.