Synthesis of 2′-modified oligonucleotides containing aldehyde or ethylenediamine groups

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1383-1385

  Zatsepin, T S ^a   Romanova, E A ^a   Stetsenko, D A ^b   Gait, M J ^b   Oretskaya, T S ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Aldehyde; Conjugate; Oligonucleotide; Peptide; Phosphoramidite

Indexed keywords

2' DIAMINOOLIGONUCLEOTIDE DERIVATIVE; 2' O (2,3 DIAMINOPROPYL)URIDINE; ALDEHYDE; AMINE; CYSTEINE DERIVATIVE; ETHYLENEDIAMINE DERIVATIVE; HYDRAZIDE; NUCLEOTIDE DERIVATIVE; OLIGONUCLEOTIDE; PEPTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; REAGENT; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; CYSTEINE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PEPTIDE NUCLEIC ACID;

AMINO TERMINAL SEQUENCE; CHEMICAL BINDING; CHEMICAL MODIFICATION; CONFERENCE PAPER; CONJUGATION; NUCLEOTIDE METABOLISM; PEPTIDE ANALYSIS; SYNTHESIS; ARTICLE;

ALDEHYDES; CYSTEINE; ETHYLENEDIAMINES; INDICATORS AND REAGENTS; OLIGONUCLEOTIDES; PEPTIDE NUCLEIC ACIDS;

EID: 0141484652     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022971     Document Type: Conference Paper

References (5)

1. Stetsenko, D.A.; Arzumanov, A.A.; Korshun, V.A.; Gait, M.J. Peptide conjugates of oligonucleotides as enhanced antisense agents. Mol. Biol. (Russ.) 2000, 34 (6), 852-859.
2. Manoharan, M. Oligonucleotide conjugates as potential antisense drugs with improved uptake, biodistribution, targeted delivery, and mechanism of action. Antisense & Nucleic Acids Drug Dev. 2002, 12 (2), 103-128.
3. Zubin, E.M.; Romanova, E.A.; Oretskaya, T.S. Modern methods for the synthesis of peptide-oligonucleotide conjugates. Russ. Chem. Rev. 2002, 71 (3), 239-264.
4. Kachalova, A.V.; Zatsepin, T.S.; Romanova, E.A.; Stetsenko, D.A.; Gait, M.J.; Oretskaya, T.S. Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2′-position. Nucleosides Nucleotides Nucleic Acids 2000, 19 (10-12), 1693-1707.
5. Zatsepin, T.S.; Stetsenko, D.A.; Arzumanov, A.A.; Romanova, E.A.; Gait, M.J.; Oretskaya, T.S. Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2′-aldehydes through thiazolidine, oxime, and hydrazine linkages. Bioconjug. Chem. 2002, 13 (4), 822-830.