The effects of chlorhexidine gel on streptococcus mutans infection in 10-month-old infants: A longitudinal, placebo-controlled, double-blind trial

Pediatric Dentistry

Volumn 25, Issue 3, 2003, Pages 215-222

  Wan, Annetta K L ^b   Seow, W Kim ^a,b   Purdie, D M ^c   Bird, P S ^b   Walsh, L J ^a,b   Tudehope, D I ^d  

^a Department of Pediatric Dentistry ^*  (Canada)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^d Mater Misericordiae Hosp   (Australia)

Author keywords

Chlorhexidine; Infants; Streptococcus mutans

Indexed keywords

CHLORHEXIDINE; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL COUNT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GEL; HEALTH BEHAVIOR; HUMAN; INFANT; LONGITUDINAL STUDY; MALE; MICROBIOLOGY; MOUTH; MOUTH HYGIENE; NONPARAMETRIC TEST; RANDOMIZED CONTROLLED TRIAL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS MUTANS; UTILIZATION REVIEW;

ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; COLONY COUNT, MICROBIAL; DOUBLE-BLIND METHOD; FEMALE; GELS; HEALTH BEHAVIOR; HUMANS; INFANT; LONGITUDINAL STUDIES; MALE; MOUTH; ORAL HYGIENE; STATISTICS, NONPARAMETRIC; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS MUTANS;

EID: 0141462687     PISSN: 01641263     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Emilson CG. Potential efficacy of chlorhexidine against mutans streptococci and dental caries. J Dent Res. 1994;73:682-691.
2. Maltz M, Zickert I, Krasse B. Effect of intensive treatment with chlorhexidine on number of Streptococcus mutans in saliva. Scand J Dent Res. 1981;89:445-449.
3. Luoma H, Seppa L, Koskinen M, Syrjanen S. Effect of chlorhexidine- fluoride applications with and without Sr and Zn on caries, plaque, and gingivitis in rats. J Dent Res. 1984;63:1193-1196.
4. Schaeken MJM, De Jong MH, Franken HCM, Van Der Hoeveri JS. Effects of highly concentrated stannous flouride and chlorhexidine regimes on human dental plaque flora. J Dent Res. 1986;65:57-61.
5. Sandham HJ, Nadeau L, Phillips MI. The effect of chlorhexidine varnish treatment on salivary mutans streptococcal levels in child orthodontic patients. J Dent Res. 1992;71:32-35.
6. Tenovuo J, Hakkinen P, Paunio P, Emilson CG. Effect of chlorhexidine-fluoride gel treatments in mothers on the establishment of mutans streptococci in primary teeth and the development of dental caries in children. Caries Res. 1992;26:275-280.
7. Gisselsson H, Birkhed D, Bjorn A-L. Effect of a 3-year professional flossing program with chlorhexidine gel on approximal caries and cost of treatment in preschool children. Caries Res. 1994;28:394-399.
8. Bratthall D, Serinirach R, Rapisuwon S, Kuratana M, Luangjarmekorn V, Luksila K, Chaipanich P. A study into the prevention of fissure caries using an antimicrobial varnish, Int Dent J. 1995;45:245-254.
9. Petersson LG, Magnusson K, Andersson H, Deierborg G, Twetman S. Effect of semi-annual applications of chlorhexidine/fluoride varnish mixture on approximal caries incidence in schoolchildren. A 3-year radiographic study. Eur J Oral Sci. 1998;106:623-627.
10. Van Lunsen DM, De Soet JJ, Weerheijm KL, Groen HJ, Veerkamp JSJ. Effects of dental treatment and single application of a 40% chlorhexidine varnish on mutans streptococci in young children under intravenous anaesthesia. Caries Res. 2000;34:268-274.
11. Emilson CG, Lindquist B. Importance of infection level of mutans streptococci for recolonization of teeth after chlorhexidine treatment. Oral Microbiol Immunol. 1998;3:64-67.
12. Emilson CG, Lindquist B, Wennerholm K. Recolonization of human tooth surfaces by Streptococcus mutans after suppression by chlorhexidine treatment. J Dent Res. 1987;66:1503-1508.
13. Sandham HJ, Brown J, Phillips HI, Chan KH. A preliminary report of long-term elimination of detectable mutans streptococci in man. J Dent Res. 1988;67:9-14.
14. Kohler B, Andreen I, Jonsson B. The earlier the colisation by mutans streptococci, the higher the caries prevalence at 4 years of age. Oral Microbiol Immunol. 1988;3:14-17.
15. Fujiwara T, Sasada E, Mina N, Ooshima T. Caries prevalence and salivary mutans streptococci in 0- to 2-year-old children of Japan. Community Dent Oral Epidemiol. 1991;19:151-154.
16. Roeters FJM, van der Hoeven JS, Burgesdijk RC, Schaeken MJM. Lactobacilli, mutans streptococci, and dental caries: a longitudinal study in 2-year-old children up to the age of 5 years. Caries Res. 1995;29:272-279.
17. Grindefjord M, Dahlof G, Nilsson B, Modeer T. Stepwise prediction of dental caries in children up to 3.5 years of age. Caries Res. 1996;30:256-266.
18. Caufield PW, Cutter GR, Dasanayake AP. Initial acquisition of mutans streptococci by infants: evidence for a discrete window of infectivity. J Dent Res. 1993;72:37-45.
19. Wan AK, Seow WK, Purdie DM, Bird PS, Walsh LJ, Tudehope DI. Association of Streptococcus mutans colonization and oral developmental nodules in predentate infants. J Dent Res. 2001;80:1945-1948.
20. Wan AK, Seow WK, Purdie DM, Bird PS, Walsh LJ, Tudehope DI. Oral colonization of Streptococcus mutans in six-month-old predentate infants. J Dent Res. 2001;80:2060-2065.
21. Seow WK, Amaratuge A, Sim R, Wan A. Prevalence of caries in urban Australian aborigines aged 1-3.5 years. Pediatr Dent. 1999;21:91-96.
22. Silness J, Loe H. Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1966;22:121-135.
23. Wilson TG, Korman KS, eds. Fundamentals of Peridontics. Chicago, Ill: Quintessence; 1996:112-348.
24. Wan AKL, Seow WK, Walsh LJ, Bird PS. Comparison of 5 selective media for the growth and enumeration of Streptococcus mutans. Aust Dent J. 2002;47:21-26.
25. De la Higuera A, Liebana J, Gutierrez J, Garcia-Mendoza A, Castillo A. Evaluation of die automicrobic system for the identification of Streptococcus mutans. Eur J Clin Microbiol Infect Dis. 1995;14:1102-1105.
26. Rudney JD, Krig MA, Neuvar EK. Longitudinal study of relations between human salivar antimicrobial proteins and measures of dental plaque accumulation and composition. Arch Oral Biol. 1993;38:377-386.
27. Nathan P, Law EJ, Murphy DF, MacMillan BG. A laboratory method for selection of topical antimicrobial agents to treat infected burn wounds. Bums. 1978;4:177-187.
28. Loesche WJ. Antimicrobials, can they be effective? In: Guggenheim B, ed. Cariology Today. Zurich, Switzerland: Karger; 1984:293-300.
29. Emilson CG, Fornell J. Effect of toothbrushing with chlorhexidine gel on salivary microflora, oral hygiene, and caries. Scand J Dent Res. 1976;84:308-319.
30. Kristofferson K, Bratthall D. Transient reduction of Streptococcus mutans interdentally by chlorhexidine gel. Scand J Dent Res. 1982;90:417-422.
31. Alaki SM, Loesche WJ, da Fonesca MA, Feigal RJ, Welch K. Preventing the transfer of Streptococcus mutans from primary molars to permanent first molars using chlorhexidine. Pediatr Dent. 2002;24:103-108.
32. Zickert I, Emilson CG, Krasse B. Effect of caries preventive measures in children highly infected with the bacterium Streptococcus mutans. Arch Oral Biol. 1982;27:861-868.
33. Lindquist E, Edward S, Torell P, Krasse B. Effect of different caries preventive measures in children highly infected with mutans streptococci. Scand J Dent Res. 1989;97:330-337.
34. Twetman S, Grindefjord M. Mutans streptococci suppression by chlorhexidine gel in toddlers. Am J Dent. 1999;12:89-91.
35. Axelsson P, Kristofferson K, Karlsson R, Bratthall D. A 30-month longitudinal study of the effect of some oral hygiene measures on Streptococcus mutans and approximal dental canes. J Dent Res. 1987;66:761-765.
36. Schaeken MJM, Schouten MJ, van der Kieboom CWA, van der Hoeven JS. Influence of contact time and concentration of chlorhexidine varnish on mutans streptococci in interproximal dental plaque. Caries Res. 1991;25:292-295.
37. Splieth C, Steffen H, Rosin M, Welk A. Caries prevention with chlorhxidine-thymol varnish in high risk schoolchildren. Community Dent Oral Epidemiol. 2000;28:419-423.