Synthesis and evaluation of 5-arylated 2(5H)-furanones and 2-arylated pyridazin-3(2H)-ones as anti-cancer agents

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 9, 2003, Pages 1259-1265

  Lattmann, Eric ^a   Ayuko, Washington O ^a   Kinchinaton, Derek ^a   Langley, Christopher A ^a   Singh, Harjit ^a   Karimi, Leila ^a   Tisdale, Michael J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2(5H) FURANONE DERIVATIVE; 3(2H) ONE DERIVATIVE; 3,4 DIBROMO 5 PHENYLFURAN 2(5H) ONE; 3,4 DICHLORO 5 (2 OXO 2 PHENYLETHYL)FURAN 2(5H) ONE; 3,4 DICHLORO 5 (4 METHOXYPHENYL)FURAN 2(5H) ONE; 3,4 DICHLORO 5 [2 [2 (2,4 DINITROPHENYL)HYDRAZONO] 2 PHENYLETHYL]FURAN 5H ONE; 3,4 DICHLORO 5 PHENYLFURAN 2(5H) ONE; 4,5 DICHLORO 2 (4 CHLOROPHENYL)PYRIDAZIN 3(2H) ONE; 4,5 DICHLORO 2 (4 METHOXY)PHENYL 3 PYRIDAZONE; 5 (3,4 DICHLORO 5 OXO 2,5 DIHYDROFURAN 2 YL)IMIDAZOLIDINE 2,4 DIONE; 5 BUTOXY 3,4 DICHLOROFURAN 2(5H) ONE; ALDEHYDE; ANTINEOPLASTIC AGENT; BUTENOLIDE; ESTER DERIVATIVE; FLUOROURACIL; HALOGEN; SULFONYLUREA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER RESISTANCE; CHEMICAL REACTION KINETICS; CHLORINATION; COLON CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; POLYMERIZATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BODY WEIGHT; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FURANS; MICE; MICE, INBRED STRAINS; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141459482     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021756     Document Type: Article

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