Disruption of sabR affects nikkomycin biosynthesis and morphogenesis in Streptomyces ansochromogenes

Biotechnology Letters

Volumn 25, Issue 18, 2003, Pages 1491-1497

  Li, Wenli ^a   Liu, Gang ^a   Tan, Huarong ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Nikkomycin; Regulatory gene; Sporulation; Streptomyces ansochromogenes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 BUTYROLACTONE RECEPTOR; 4-BUTYROLACTONE RECEPTOR; AMINOGLYCOSIDE; ARPA PROTEIN, STREPTOMYCES GRISEUS; BACTERIAL PROTEIN; DNA BINDING PROTEIN; GAMMA BUTYROLACTONE; ISOPROTEIN; NIKKOMYCIN; RECOMBINANT PROTEIN; REPRESSOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; COMPARATIVE STUDY; EVALUATION; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; MORPHOGENESIS; MUTATION; PHYSIOLOGY; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STREPTOMYCES;

4-BUTYROLACTONE; AMINO ACID SEQUENCE; AMINOGLYCOSIDES; BACTERIAL PROTEINS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN ISOFORMS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOMYCES;

BACTERIA (MICROORGANISMS); STREPTOMYCES; STREPTOMYCES ANSOCHROMOGENES; STREPTOMYCES GRISEUS;

EID: 0141454791     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025402902098     Document Type: Article

References (17)

1. Champness W (2000) Prokaryotic development. In: Yves VB, Lawrence JS, eds. Actinomycete Development, Antibiotic Production, and Phytogeny: Questions and Challenges. Wahshington. DC: ASM Press, pp. 11-31.
2. Engel P, Scharfenstein L, Dyer JM (2001) Disruption of a gene encoding a putative γ-butyrolactone-binding protein in Streptomyces tendae affects nikkomycin production. Appl. Microbiol. Biotechnol. 56: 414-419.
3. Hector RF, Zimmer BL, Pappagianis D (1990) Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis. Antimicrob. Ag. Chemother. 34: 587-593.
4. Horinouchi S, Beppu T (1994) A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus. Mol. Microbiol. 12: 859-864.
5. Ishikawa J, Hotta K (1999) FramePlot: a new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content. FEMS Microbiol. Lett. 174: 251-253.
6. Kieser T, Bibb MJ, Buttner MJ, Chater KF, Hopwood DA (2000) Practical Streptomyces Genetics. Norwich, UK: John Innes Foundation.
7. Kisker C, Hinrichs W, Tovar K, Hillen W, Saenger W (1995) The complex formed between Tet repressor and tetracycline-Mg2+ reveals mechanism of antibiotic resistance. J. Mol. Biol. 247: 260-280.
8. Li W, Tan H (2003) Structure and function of sanV: a gene involved in nikkomycin biosynthesis of Streptomyces ansochromogenes. Curr. Microbiol. 46: 403-407.
9. Miyake K, Kuzuyama T, Horinouchi S, Beppu T (1990) The A-factor-binding protein of Streplomyces griseus negatively controls streptomycin production and sporulation. J. Bacteriol. 172(6): 3003-3008.
10. Möhrie V, Roos U, Bormann C (1995) Identification of cellular proteins involved in nikkomycin production in Streptomyces tendae Tü901. Mol. Microbiol. 15: 561-571.
11. Mueller H, Further R, Zaehner H (1981) Effect of nikkomycinZ, nikkomycinX and polyoxinA on chitosornalchitin synthetase. Arch. Microbiol. 130: 195-197.
12. Onaka H, Nakagawa T, Horinouchi S (1998) Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis. Mol. Microbiol. 28: 743-753.
13. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular Cloning: A Laboratory Mannual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
14. Takano E, Chakraburtty R, Nihira T (2001) A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2). Mol. Microbiol. 41: 1015-1026.
15. Xu J, Liu G, Tan H (2003) sanC - a novel gene involved in nikkomycin biosynthesis in Streptomyces ansochromogenes. Lett. Appl. Microbiol. 36: 234-238.
16. Yamada Y (1999) Autoregulatory factors and regulation of antibiotic production in Streptomyces. In: Hobbs RR, Bainton NJ, Roberts DMcL, eds. Microbial Signalling and Communication. Cambridge, UK: Cambridge University Press, pp. 177-196.
17. Zeng H, Tan H, Li J (2002) Cloning and function of sanQ: a gene involved in nikkomycin biosynthesis of Streptomyces ansochromogenes. Curr. Microbiol. 45: 175-179.