-
1
-
-
0033549840
-
Drug treatment of lipid disorders
-
note
-
Knopp RH: Drug treatment of lipid disorders. New Engl J Med (1999) 341:498-511. A comprehensive review of the history and perspectives for the use of statins to treat lipid disorders.
-
(1999)
New Engl J Med
, vol.341
, pp. 498-511
-
-
Knopp, R.H.1
-
2
-
-
0344589406
-
Methods and endpoints issues in clinical development of lipid-acting agents with pleiotropic effects
-
note
-
Davignon J: Methods and endpoints issues in clinical development of lipid-acting agents with pleiotropic effects. Am J Cardiol (1998) 81(Suppl 1):17F-24F. A comprehensive review discussing and exemplifying pleiotropic effects of statins and issues involved in their clinical development. Described pleiotropism provides a basis for the broad claims regarding clinical usage of statins.
-
(1998)
Am J Cardiol
, vol.81
, Issue.SUPPL. 1
-
-
Davignon, J.1
-
3
-
-
0034177738
-
Effect of fluvastatin on QT dispersion: A new pleiotropic effect?
-
Mark L, Katona A: Effect of fluvastatin on QT dispersion: A new pleiotropic effect? Am J Cardiol (2000) 85(7):919-920.
-
(2000)
Am J Cardiol
, vol.85
, Issue.7
, pp. 919-920
-
-
Mark, L.1
Katona, A.2
-
4
-
-
0031736899
-
Are there potential non-lipid lowering uses of statins?
-
Wheeler DC: Are there potential non-lipid lowering uses of statins? Drugs (1998) 56(4):517-522.
-
(1998)
Drugs
, vol.56
, Issue.4
, pp. 517-522
-
-
Wheeler, D.C.1
-
5
-
-
0031965513
-
Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake
-
Brown MS, Goldstein JL: Sterol regulatory element binding proteins (SREBPs): Controllers of lipid synthesis and cellular uptake. Nutr Rev (1998) 56:S1-S3.
-
(1998)
Nutr Rev
, vol.56
-
-
Brown, M.S.1
Goldstein, J.L.2
-
6
-
-
0032555154
-
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
-
Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK: Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA (1998) 95(15):8880-8885.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.15
, pp. 8880-8885
-
-
Endres, M.1
Laufs, U.2
Huang, Z.3
Nakamura, T.4
Huang, P.5
Moskowitz, M.A.6
Liao, J.K.7
-
7
-
-
0032508533
-
Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
-
Laufs U, Liao J: Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem (1998) 273(37):24266-24271.
-
(1998)
J Biol Chem
, vol.273
, Issue.37
, pp. 24266-24271
-
-
Laufs, U.1
Liao, J.2
-
8
-
-
0034671138
-
Attenuating cardiovascular risk factors in patients with type 2 diabetes
-
Garber AJ: Attenuating cardiovascular risk factors in patients with type 2 diabetes. Am Family Physician (2000) 62 (12):2633-2646.
-
(2000)
Am Family Physician
, vol.62
, Issue.12
, pp. 2633-2646
-
-
Garber, A.J.1
-
9
-
-
0032559362
-
Rho GTPases and their actin cytoskeleton
-
Hall A: Rho GTPases and their actin cytoskeleton. Science (1998) 279(5350):509-514.
-
(1998)
Science
, vol.279
, Issue.5350
, pp. 509-514
-
-
Hall, A.1
-
10
-
-
0034638746
-
Statins and the risk of dementia
-
Jick H, Zomberg GL, Jick SS, Seshadri S, Drachman DA: Statins and the risk of dementia. Lancet (2000) 356(9242):1627-1631.
-
(2000)
Lancet
, vol.356 9242
, pp. 1627-1631
-
-
Jick, H.1
Zomberg, G.L.2
Jick, S.S.3
Seshadri, S.4
Drachman, D.A.5
-
11
-
-
0001925205
-
Biomechanics of bone
-
Bilezikian JP, Raisz LG, Rodan GA (Eds), Academic Press, San Diego
-
Einhorn TA: Biomechanics of bone. In: Principles of Bone Biology (1996) Bilezikian JP, Raisz LG, Rodan GA (Eds), Academic Press, San Diego, pp 25-37.
-
(1996)
Principles of Bone Biology
, pp. 25-37
-
-
Einhorn, T.A.1
-
12
-
-
0035212177
-
Statins and their potential for osteoporosis
-
note
-
Mundy GR: Statins and their potential for osteoporosis. Bone (2001) 29(6):495-497. Results demonstrating the pleiotropic effects of statins on the skeleton and exemplifying the use of statins for osteoporosis, based on preclinical data and moderate clinical evidence.
-
(2001)
Bone
, vol.29
, Issue.6
, pp. 495-497
-
-
Mundy, G.R.1
-
13
-
-
0141677484
-
(E)-7(4-fluorophenyl)-6-isopropyl-2-mesylaminopyridin-5-yl)-(3R,5S)-dihy droxyhept-6-enoic acid
-
WO-00185702
-
AstraZeneca plc (Hill SJ, Lenz EM, Phillips PJ): (E)-7(4-fluorophenyl)-6-isopropyl-2-mesylaminopyridin-5-yl)-(3R,5S)-dihydroxyhep t-6-enoic acid. WO-00185702 (2001).
-
(2001)
-
-
Hill, S.J.1
Lenz, E.M.2
Phillips, P.J.3
-
14
-
-
0141566081
-
HMG-CoA reductase inhibitors and method
-
WO-00196311
-
Bristol-Myers Squibb Co (Robl JA, Chen B-C, Sun C-Q): HMG-CoA reductase inhibitors and method. WO-00196311 (2001).
-
(2001)
-
-
Robl, J.A.1
Chen, B.-C.2
Sun, C.-Q.3
-
15
-
-
0141566081
-
HMG-CoA reductase inhibitors and method
-
WO-00196347
-
Bristol-Myers Squibb Co (Robl JA, Chen B-C, Sun C-Q): HMG-CoA reductase inhibitors and method. WO-00196347 (2001).
-
(2001)
-
-
Robl, J.A.1
Chen, B.-C.2
Sun, C.-Q.3
-
16
-
-
25744444523
-
Method of treating amyloid beta precursor disorders
-
WO-00132161
-
Andrx Corp (Friedhoff L, Buxbaum J): Method of treating amyloid beta precursor disorders. WO-00132161 (2000).
-
(2000)
-
-
Friedhoff, L.1
Buxbaum, J.2
-
17
-
-
4243513447
-
Methods of ameliorating abnormal bone states
-
WO-00137876
-
Bayer AG (Bagi CM): Methods of ameliorating abnormal bone states. WO-00137876 (2000).
-
(2000)
-
-
Bagi, C.M.1
-
18
-
-
25744432086
-
Treatment of hyperproliferative, inflammatory and related mucocutaneous disorders using inhibitors of mevalonate synthesis and metabolism
-
WO-00178706
-
Cellegy Pharmaceuticals Inc (Parks TP, Grayson S): Treatment of hyperproliferative, inflammatory and related mucocutaneous disorders using inhibitors of mevalonate synthesis and metabolism. WO-00178706 (2001).
-
(2001)
-
-
Parks, T.P.1
Grayson, S.2
-
19
-
-
25744437910
-
Liver-selective therapy
-
WO-00132162
-
Howard J Smith & Associates Pty Ltd (Smith HJ): Liver-selective therapy. WO-00132162 (2000).
-
(2000)
-
-
Smith, H.J.1
-
20
-
-
4244007023
-
Methods of modulating matrix metalloproteinase activity and uses thereof
-
WO-00110437
-
St Louis University (Partridge NC): Methods of modulating matrix metalloproteinase activity and uses thereof. WO-00110437 (2000).
-
(2000)
-
-
Partridge, N.C.1
-
21
-
-
0141454554
-
Method of modulating expression of LDL-receptor-related protein and uses thereof
-
WO-00203985
-
St Louis University (Partridge NC): Method of modulating expression of LDL-receptor-related protein and uses thereof. WO-00203985 (2001).
-
(2001)
-
-
Partridge, N.C.1
-
22
-
-
25744463557
-
Use of compound or pharmaceutical composition for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour development and for wound healing
-
WO-00111038
-
Université Catholique De Louvain (Balligand J-L, Feron O): Use of compound or pharmaceutical composition for the prevention and/or the treatment of ischemic heart and peripheral vascular diseases, tumour development and for wound healing. WO-00111038 (2000).
-
, vol.2000
-
-
Balligand, J.-L.1
Feron, O.2
-
23
-
-
25744450633
-
Method of treating cardiovascular disease
-
WO-00197809
-
American Home Products Corp (Azrolan NI, Sehgal SN, Adelman SJ): Method of treating cardiovascular disease. WO-00197809 (2001).
-
(2001)
-
-
Azrolan, N.I.1
Sehgal, S.N.2
Adelman, S.J.3
-
24
-
-
25744465109
-
Combinations of statins, estrogenic agents and optionally estrogens
-
WO-00203977
-
American Home Products Corp (Jenkins SN, Komm BS, Miller CP): Combinations of statins, estrogenic agents and optionally estrogens. WO-00203977 (2001).
-
(2001)
-
-
Jenkins, S.N.1
Komm, B.S.2
Miller, C.P.3
-
25
-
-
4243997809
-
Novel remedies with the use of beta 3 agonist
-
WO-00154728
-
Asahi Kasei Corp (Ogawa K, Umeno H): Novel remedies with the use of beta 3 agonist. WO-00154728 (2001).
-
(2001)
-
-
Ogawa, K.1
Umeno, H.2
-
26
-
-
25744469032
-
New combination of a betablocker and a cholesterol-lowering agent
-
WO-00174394
-
AstraZeneca plc (Bondjers G, Wiklund O, Wikstrand J): New combination of a betablocker and a cholesterol-lowering agent. WO-00174394 (2001).
-
(2001)
-
-
Bondjers, G.1
Wiklund, O.2
Wikstrand, J.3
-
27
-
-
4243493042
-
Novel combination for treatment of sexual dysfunction
-
WO-00119357
-
Bayer AG (Bischoff E, Bischoff H, Giuliano F): Novel combination for treatment of sexual dysfunction. WO-00119357 (2000).
-
(2000)
-
-
Bischoff, E.1
Bischoff, H.2
Giuliano, F.3
-
28
-
-
0141789462
-
Combination of cerivastatin with ACE inhibitors and the use thereof in medicaments
-
WO-00189525
-
Bayer AG (Wagener G, Ippen J): Combination of cerivastatin with ACE inhibitors and the use thereof in medicaments. WO-00189525 (2001).
-
(2001)
-
-
Wagener, G.1
Ippen, J.2
-
30
-
-
0141677472
-
Use of CSE inhibitors for treating heart failure
-
WO-00178747
-
Bayer AG (Bischoff H, Bauersachs J, Ertl G, Fraccarollo D): Use of CSE inhibitors for treating heart failure. WO-00178747 (2001).
-
(2001)
-
-
Bischoff, H.1
Bauersachs, J.2
Ertl, G.3
Fraccarollo, D.4
-
31
-
-
25744468238
-
Medicinal compositions for treating colorectal cancer
-
WO-00102014
-
Hisamitsu Pharmaceutical Co Inc (Tanida N, Goto T, Tomizawa N): Medicinal compositions for treating colorectal cancer. WO-00102014 (2000).
-
(2000)
-
-
Tanida, N.1
Goto, T.2
Tomizawa, N.3
-
32
-
-
4243311701
-
Method and compositions for inhibiting arteriosclerosis
-
WO-00185155
-
Kaneka Corp (Fujii K, Kawabe T, Hosoe K, Hidaka T): Method and compositions for inhibiting arteriosclerosis. WO-00185155 (2001).
-
(2001)
-
-
Fujii, K.1
Kawabe, T.2
Hosoe, K.3
Hidaka, T.4
-
33
-
-
4243810872
-
Anti-hypercholesterolemic drug combination
-
WO-00122962
-
Merck & Co Inc (Chao Y-S): Anti-hypercholesterolemic drug combination. WO-00122962 (2000).
-
(2000)
-
-
Chao, Y.-S.1
-
34
-
-
4243811245
-
Combination therapy for treating neurodegenerative disease
-
WO-00145698
-
Merck & Co Inc (Waldstreicher J): Combination therapy for treating neurodegenerative disease. WO-00145698 (2000).
-
(2000)
-
-
Waldstreicher, J.1
-
35
-
-
0242495970
-
Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
-
WO-00146206
-
Merck Frosst Canada & Co (Leblanc Y, Dufresne C, Gauthier JY, Lau CK, Li CS, Roy P, Therien M, Scheigetz J, Wang Z): Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B). WO-00146206 (2000).
-
(2000)
-
-
Leblanc, Y.1
Dufresne, C.2
Gauthier, J.Y.3
Lau, C.K.4
Li, C.S.5
Roy, P.6
Therien, M.7
Scheigetz, J.8
Wang, Z.9
-
36
-
-
0141454557
-
Sulfur-substituted aryldifluoromethylphosphonic acids as PTP-1b inhibitors
-
WO-00170753
-
Merck Frosst Canada & Co (Li CS, Lau CK, Therien M, Gauthier JY, Bayly C, Dufresne C, Fortin R, Leblanc Y, Roy P, et al): Sulfur-substituted aryldifluoromethylphosphonic acids as PTP-1b inhibitors. WO-00170753 (2001).
-
(2001)
-
-
Li, C.S.1
Lau, C.K.2
Therien, M.3
Gauthier, J.Y.4
Bayly, C.5
Dufresne, C.6
Fortin, R.7
Leblanc, Y.8
Roy, P.9
-
37
-
-
0242664403
-
Sulfur-substituted aryldifluoromethylphosphonic acids as PTP-1b inhibitors
-
WO-00170754
-
Merck Frosst Canada & Co (Bayly C, Ohkubo M): Sulfur-substituted aryldifluoromethylphosphonic acids as PTP-1b inhibitors. WO-00170754 (2001).
-
(2001)
-
-
Bayly, C.1
Ohkubo, M.2
-
38
-
-
25744469033
-
Combination of organic compounds
-
WO-00176573
-
Novartis AG (De Gasparo M, Graves KC): Combination of organic compounds. WO-00176573 (2001).
-
(2001)
-
-
De Gasparo, M.1
Graves, K.C.2
-
39
-
-
4243881671
-
Compositions and methods for treating osteoporosis
-
EP-01127573
-
Pfizer Products Inc (Day WW, Lee AG, Thompson DD): Compositions and methods for treating osteoporosis. EP-01127573 (2001).
-
(2001)
-
-
Day, W.W.1
Lee, A.G.2
Thompson, D.D.3
-
40
-
-
25744465110
-
Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
-
WO-00168096
-
Pharmacia Corp (Keller BT, Tremont SJ, Glenn KC, Manning RE): Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders. WO-00168096 (2001).
-
(2001)
-
-
Keller, B.T.1
Tremont, S.J.2
Glenn, K.C.3
Manning, R.E.4
-
41
-
-
25744456708
-
Drug comprising combination
-
WO-00158491
-
Takeda Chemical Industries Ltd (Sugiyama Y, Odaka H, Naruo K-I): Drug comprising combination. WO-00158491 (2001).
-
(2001)
-
-
Sugiyama, Y.1
Odaka, H.2
Naruo, K.-I.3
-
42
-
-
0141677480
-
TNF-α inhibitors
-
WO-00158443
-
Takeda Chemical Industries Ltd (Sugiyama Y, Odaka H, Naruo K, Funatsu M, Ikeya K, Suzuki Y): TNF-α inhibitors. WO-00158443 (2001).
-
(2001)
-
-
Sugiyama, Y.1
Odaka, H.2
Naruo, K.3
Funatsu, M.4
Ikeya, K.5
Suzuki, Y.6
-
43
-
-
0141789458
-
LXR modulators
-
WO-00160818
-
Tularik Inc (Li L, Medina JC, Shan B): LXR modulators. WO-00160818 (2000).
-
(2000)
-
-
Li, L.1
Medina, J.C.2
Shan, B.3
-
44
-
-
49249132404
-
HMG-CoA reductase inhibitor extended release formulation
-
WO-00134123
-
Andrx Corp (Chen C-M, Chou J, Wong D): HMG-CoA reductase inhibitor extended release formulation. WO-00134123 (2000).
-
(2000)
-
-
Chen, C.-M.1
Chou, J.2
Wong, D.3
-
45
-
-
0141454555
-
Pharmaceutical compositions comprising a HMG reductase inhibitor
-
WO-00154668
-
AstraZeneca plc (Creekmore JR, Wiggins NA): Pharmaceutical compositions comprising a HMG reductase inhibitor. WO-00154668 (2000).
-
(2000)
-
-
Creekmore, J.R.1
Wiggins, N.A.2
-
46
-
-
0141454555
-
Pharmaceutical compositions comprising a HMG CoA reductase inhibitor
-
WO-00154669
-
AstraZeneca plc (Creekmore JR, Wiggins NA): Pharmaceutical compositions comprising a HMG CoA reductase inhibitor. WO-00154669 (2000).
-
(2000)
-
-
Creekmore, J.R.1
Wiggins, N.A.2
-
47
-
-
0141677468
-
Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] -(3R,5S)-3,5-dihydroxyhept-6-enoic acid
-
WO-00160804
-
AstraZeneca PLC (Taylor NP, Okada T): Crystalline salts of 7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl] -(3R,5S)-3,5-dihydroxyhept-6-enoic acid. WO-00160804 (2001).
-
(2001)
-
-
Taylor, N.P.1
Okada, T.2
-
48
-
-
4244062695
-
Process for manufacturing simvastatin and the novel intermediates
-
WO-00134590
-
Biocon India Ltd (Sambasivam G, Sridharan M, Acharya P, Mathew J): Process for manufacturing simvastatin and the novel intermediates. WO-00134590 (1999).
-
(1999)
-
-
Sambasivam, G.1
Sridharan, M.2
Acharya, P.3
Mathew, J.4
-
49
-
-
0141677424
-
Synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methyle thyl)-3-phenyl-4-[(phenylamino)carbonyl)]-1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin)
-
WO-00172706
-
Biocon India Ltd (Sambasivan G, Sridharan M, Padudevastana S, Poornaprajna A, Matthew J, Srinath S, Nair S): Synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methyle thyl)-3-phenyl-4-[(phenylamino)carbonyl)]-1H-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin). WO-00172706 (2000).
-
(2000)
-
-
Sambasivan, G.1
Sridharan, M.2
Padudevastana, S.3
Poornaprajna, A.4
Matthew, J.5
Srinath, S.6
Nair, S.7
-
50
-
-
25744434270
-
Process for recovering statin compounds from a fermentation broth
-
WO-00139768
-
Biological Gyogyszergyar RT (Keri V, Deak L, Forgacs I, Szabo C, Nagyne EA): Process for recovering statin compounds from a fermentation broth. WO-00139768 (2000).
-
(2000)
-
-
Keri, V.1
Deak, L.2
Forgacs, I.3
Szabo, C.4
Nagyne, E.A.5
-
51
-
-
0141566073
-
A process for producing simvastatin
-
WO-00172734
-
Cheil Je Dang Corp (Lee KH, Kim JW, Choi KD, Bae H): A process for producing simvastatin. WO-00172734 (2000).
-
(2000)
-
-
Lee, K.H.1
Kim, J.W.2
Choi, K.D.3
Bae, H.4
-
52
-
-
4243329298
-
Process for the preparation of indole derivatives and intermediates of the process
-
WO-00192223
-
Ciba Specialty Chemicals Holding Inc (Wolleb A, Wolleb H): Process for the preparation of indole derivatives and intermediates of the process. WO-00192223 (2001).
-
(2001)
-
-
Wolleb, A.1
Wolleb, H.2
-
53
-
-
25744456706
-
Hydroxylation of compactin to pravastatin by micromonospora
-
WO-00104340
-
Gyogyszerkutato Intezet KFT (Jekkel A, Ambrus G, Ilkoy E, Horvath I, Konya A, Szabo IM, Nagy Z, Horvath G, Mozes J et al): Hydroxylation of compactin to pravastatin by micromonospora. WO-00104340 (2000).
-
(2000)
-
-
Jekkel, A.1
Ambrus, G.2
Ilkoy, E.3
Horvath, I.4
Konya, A.5
Szabo, I.M.6
Nagy, Z.7
Horvath, G.8
Mozes, J.9
-
54
-
-
25744464322
-
Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
-
WO-00193860
-
Lek Pharmaceutical and Chemical Co DD (Pflaum Z, Kere J): Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same. WO-00193860 (2000).
-
(2000)
-
-
Pflaum, Z.1
Kere, J.2
-
55
-
-
25744462785
-
Stable pharmaceutical product and formulation
-
WO-00193859
-
Lek Pharmaceuticl and Chemical Co DD (Pflaum Z, Milivojevic D, Rucman B, Kogej S): Stable pharmaceutical product and formulation. WO-00193859 (2000).
-
(2000)
-
-
Pflaum, Z.1
Milivojevic, D.2
Rucman, B.3
Kogej, S.4
-
56
-
-
4243868947
-
Crystals of the sodium salt of pravastatin
-
WO-00110813
-
Lek Pharmaceutical and Chemical Co DD (Pflaum Z): Crystals of the sodium salt of pravastatin. WO-00110813 (2000).
-
(2000)
-
-
Pflaum, Z.1
-
57
-
-
4243963334
-
Process for the preparation of amorphous atorvastatin
-
WO-00142209
-
Lek Pharmaceutical and Chemical Co DD (Pflaum Z): Process for the preparation of amorphous atorvastatin. WO-00142209 (2000).
-
(2000)
-
-
Pflaum, Z.1
-
59
-
-
4244216874
-
Method of production flavastatin
-
JP-13286293
-
Nichiiko Pharmaceutical Co Ltd (Okabe M): Method of production flavastatin. JP-13286293 (2000).
-
(2000)
-
-
Okabe, M.1
-
60
-
-
25744450632
-
Process for producing 2-aminobenzophenone compound
-
US-06310249
-
Nissan Chemical Industries Ltd (Matsumoto H, Horiuchi T): Process for producing 2-aminobenzophenone compound. US-06310249 (1999).
-
(1999)
-
-
Matsumoto, H.1
Horiuchi, T.2
-
61
-
-
4244071374
-
Process for the preparation of quinoline derivative and intermediate therefor
-
US-06335449
-
Nissan Chemical Industries Ltd (Ohara Y, Suzuki M, Yanagawa Y, Takada Y): Process for the preparation of quinoline derivative and intermediate therefor. US-06335449 (1999).
-
(1999)
-
-
Ohara, Y.1
Suzuki, M.2
Yanagawa, Y.3
Takada, Y.4
-
62
-
-
0141677469
-
A therapeutic mixture of HMG-CoA reductase inhibitors
-
WO-00128499; note
-
NitroSystems Inc (Miller RA): A therapeutic mixture of HMG-CoA reductase inhibitors. WO-00128499 (2000). Example of claims where the combination of two different classes of statins could be used to achieve synergism in a known disease area, or to expand the claims to 'new' disease areas based on pleiotropic properties of one or both statins used in combination.
-
(2000)
-
-
Miller, R.A.1
-
63
-
-
25744454577
-
Organic compounds
-
US-06242003
-
Novartis AG (Kalb OM, Valazza SJ): Organic compounds. US-06242003 (2000).
-
(2000)
-
-
Kalb, O.M.1
Valazza, S.J.2
-
64
-
-
25744444524
-
Process for the preparation of sodium salts of statins
-
WO-00144144
-
Ranbaxy Laboratories Ltd (Narula P, Raman S, Kumar ML, Kumar P): Process for the preparation of sodium salts of statins. WO-00144144 (2000).
-
(2000)
-
-
Narula, P.1
Raman, S.2
Kumar, M.L.3
Kumar, P.4
-
65
-
-
25744453804
-
Process for the isolation of lovastatin
-
WO-00200615
-
Ranbaxy Laboratories Ltd (Kumar P, Raman S, Narula P): Process for the isolation of lovastatin. WO-00200615 (2001).
-
(2001)
-
-
Kumar, P.1
Raman, S.2
Narula, P.3
-
67
-
-
0141677467
-
A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
-
WO-00166538
-
Teva Pharmaceuticals USA Inc (Keri V, Forgas I): A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities. WO-00166538 (2001).
-
(2001)
-
-
Keri, V.1
Forgas, I.2
-
68
-
-
0141789414
-
A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt
-
WO-00144180
-
Warnere Lambert R&D Ireland Ltd (Tully W): A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt. WO-00144180 (2000).
-
(2000)
-
-
Tully, W.1
-
69
-
-
0141454549
-
A process for producing crystalline atorvastatin calcium
-
WO-00144181
-
Warner Lambert R&D Ireland Ltd (Connell J, Tully W, Madigan E): A process for producing crystalline atorvastatin calcium. WO-00144181 (2000).
-
(2000)
-
-
Connell, J.1
Tully, W.2
Madigan, E.3
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