Synergistic effect of nicorandil and amlodipine on lysosomal hydrolases during experimental myocardial infarction in rats

Biomedicine and Pharmacotherapy

Volumn 57, Issue 7, 2003, Pages 309-313

  Sathish, Venkatachalem ^a   Ebenezar, Kesavarao Kumar ^a   Devaki, Thiruvengadam ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Amlodipine; Lysosomal hydrolases; Myocardial infarction; Nicorandil

Indexed keywords

ACID PHOSPHATASE; AMLODIPINE; BETA GALACTOSIDASE; BETA GLUCURONIDASE; CATHEPSIN D; ISOPRENALINE; LYSOSOME ENZYME; N ACETYL BETA GLUCOSAMINIDASE; NICORANDIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; HEART INFARCTION; HEART PROTECTION; LYSOSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0141448851     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(03)00036-2     Document Type: Article

References (34)

1. Taira N. Nicorandil as a hybrid between nitrates and potassium channel activators. Am J Cardiol. 63:1989;J18-J24.
2. Furukwa K., Itoh T., Kajiwara M., Kitamura K., Suzuki H., Ito Y., et al. Vasodilating actions of 2-nicotinamidoethyl nitrate on porcine and guinea-pig coronary arteries. J Pharmacol Exp Ther. 218:1981;248-259.
3. Pieper G.M., Gross G.J. Anti-free-radical and neutrophil modulating properties of the nitrovasdilator nicorandil. Cardiovasc Drugs Ther. 6:1990;225-232.
4. Sevanian A., Shen L., Ursini F. Inhibition of LDL oxidation and oxidized LDL-induced cytotoxicity by dihydropyridine calcium antagonists. Pharm Res. 17:2000;999-1006.
5. Decker R.S., Poole A.R., Griffin E.E., Dingle J.T., Wildenthal K. Altered distribution of lysosomal cathepsin-D in ischemic myocardium. J Clin Invest. 59:1977;911-921.
6. Sushamakumari S., Jayadeep A., Sureshkumar J.S., Menon V.P. Effects of carnitine on malondiadehyde, taurine, glutathione levels in heart of rats subjected to myocardial stress by isoproterenol. Indian J Exp Biol. 27:1989;134-137.
7. Ravichandran L.V., Puvanakrishnan R., Joseph K.T. Influence of isoproterenol induced myocardial infarction on certain glycohydrolases and cathepsins in rats. Biochem Med Metab Biol. 45:1991;6-15.
8. Hoffstein S., Gennaro D.E., Weissmann G., Hirsch J., Streuli F., Fox A.C. Cytochemical localization of lysosomal enzyme activity in normal and ischemic dog myocardium. Am J Pathol. 79:1975;193-206.
9. Todd G.L., Cullan G.E., Cullan G.M. Isoproterenol-induced myocardial necrosis and membrane permeability alteration in the isolated perfused rabbit heart. Exp Mol Pathol. 33:1980;43-54.
10. Sathish V., Vimal V., Ebenezar K.K., Devaki T. Synergistic effect of nicorandil and amlodipine on mitochondrial function during isoproterenol induced myocardial infarction in rats. J Pharm Pharmacol. 54:2002;133-137.
11. Sathish V., Ebenezar K.K., Devaki T. Synergistic effect of nicorandil and amlodipine on tissue defense system during experimental myocardial infarction in rats. Mol Cell Biochem. 243:2003;133-138.
12. Wildenthal K. Lysosomes and lysomal enzymes in the heart. Dingle J.T., Dean R.T. Lysosomes in biology and pathology. 1975;167-190. Amsterdam: North Holland.
13. Sreepriya M., Saravanan N., Devaki T., Nayeem M. Protective effects of L-arginine on experimental myocardial injury induced by β-adrenergic stimulation in rats. J Clin Biochem Nutr. 27:1999;19-26.
14. Kawai Y., Anno K. Mucopolysaccharides degrading enzymes from the liver of the squid ommastrephes sloani pacificus. I. Hyaluronidase. Biochim Biophys Acta. 242:1971;428-436.
15. Moore J.C., Morris J.E. A simple automated colorimetric method for determination of N-acetyl β-D-glucosaminidase. Ann Clin Biochem. 19:1982;157-159.
16. Conchie J., Gelman A.L., Levvy G.A. Inhibition of glycosidases by aldonolactones of corresponding configuration. The C-4 and C-6 specificity of beta glucosidase and beta galactocidase. Biochem J. 103:1967;609-615.
17. Sapolsky A.L., Altman R.D., Howell D.S. Cathepsin-D activity in normal and ostearthritic human cartilage. Fedn Proc. 32:1973;1489-1493.
18. King J. The hydrolases-acid and alkaline phosphatases. Van D. Practical clinical enzymology. 1965;191-208 Nostrand, London.
19. Riccutti M.A. Myocardial lysosome stability in the early stages of acute ischemic injury. Am J Cardiol. 30:1992;492-497.
20. Decker R.S., Wildenthal K. Sequential lysosomal alterations during cardiac ischemia. II. Ultrastructural and cytochemical changes. Lab Invest. 38:1978;662-673.
21. Ravichandran L.V., Puvanakrishnan R., Joseph K.T. Alterations in the heart lysosomal stability in isoproterenol induced myocardial infarction in rats. Biochem Int. 22:1990;387-396.
22. Kalra J., Prasad K. Oxygen free radicals and cardiac depression. Clin Biochem. 27:1994;163-168.
23. Chen J.W., Murphy T.L., Willingham M.C., Patan I., August J.T. Identification of two lysosomal membrane glycoproteins. J Cell Biol. 101:1985;85-95.
24. Macickova T., Navarova J., Urbancikova M., Horakova K. Comparison of isoproterenol induced changes in lysosomal enzyme activity in vivo and in vitro. Gen Phisol Biophys. 18:1999;86-91.
25. Mayanskaya S.D., Mayanskaya N.N., Efremov A.V., Yakobson G.S. Activity of lysosomal apparatus in rat myocardium during experimental coronary and noncoronary myocardial damage. Bull Exp Bio M. 129:2000;530-532.
26. Kennett F.F., Weglicki W.B. Effects of well-defined ischemia on myocardial lysosomal and microsomal enzymes in a canine model. Cir Res. 43:1978;750-758.
27. Janero D.R., Burghardt B. Antiperoxidant effects of dihydropyridine calcium antaonists. Biochem Pharmacol. 38:1989;4344-4348.
28. Mak I.T., Boehme P., Weglicki W.B. Antioxidant effect of calcium channel blockers against free radical injury in endothelial cells: cell correlation of protection with preservation of glutathione levels. Circ Res. 70:1992;1099-1103.
29. Mason R.P., Campbell S.F., Wang S.D., Herbette L.G. Comparison of location and binding for the positively charged 1,4-dihydropyridine calcium channel antagonists amlodipine with uncharged drugs of this class in cardiac membranes. Mol Pharmacol. 36:1989;634-640.
30. Mason R.P., Moisey D.M., Shajenko L. Cholesterol alters the binding of calcium channel blockers to the membrane lipid bilayer. Mol Pharmacol. 41:1992;315-321.
31. Naito A., Aniya Y., Sakanashi M. Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathion-S-transferase and lipid peroxidation. Jpn J Pharmacol. 65:1994;209-213.
32. Mason R.P., Walter M.F., Trubbore M.W., Olmstead E.G. Jr, Mason P.E. Membrane antioxidant effects of charged dihydropyridine calcium antagonist, amlodipine. J Mol Cell Cardiol. 31:1999;275-281.
33. Kramsch D.M., Sharma R.C. Limits of lipid lowering therapy: the benefits of amlodipine as an anti-atherosclerotic agent. J Hum Hypertens. 9:1995;S3-S9.
34. Chen L., Haught W.H., Yang B., Saldeen T.G.T., Parathasarathy S., Metha J.L. Preservation of endogenus antioxidant activity and inhibition of lipid peroxidation as common mechanism of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine. J Am Coll Cardiol. 30:1997;569-575.