Experimental Atmosphere Monitoring in Gasoline Vapor Inhalation Studies

Toxicology Methods

Volumn 6, Issue 2, 1996, Pages 65-82

  Kumarathasan, Prem ^a   Vincent, Renaud ^a,c   Tardif, Robert ^b   Potvin, Marc ^a   Bjarnason, Stephen ^a   Poon, Raymond ^a   Moir, David ^a   Chu, Ih ^a  

^a HEALTH CANADA   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c Environmental Health Centre Ottawa   (Canada)

Author keywords

Alternative fuel; Chemical mixtures; Gasoline; Inhalation toxicology; M 85; Physiologically based pharmacokinetics

Indexed keywords

EID: 0141448415     PISSN: 10517235     EISSN: None     Source Type: Journal    
DOI: 10.3109/15376519609068454     Document Type: Article

References (26)

1. Sawyer RF. Trends in auto emissions and gasoline compositions. Environ Health Perspect 1993;101(suppl 6):5-12.
2. Tilbury L, Butterworth BE, Moss O, Goldsworthy TL. Hepatocyte cell proliferation in mice after inhalation exposure to unleaded gasoline vapour. J Toxicol Environ Health 1993;38:293-307.
3. Infante PF. State of the science on the carcinogenicity of gasoline with particular reference to cohort mortality study results. Environ Health Perspect. 1993;101 (suppl 6):105-109.
4. Health Effects Institute. A Special Report: Automotive Methanol Vapours and Human Health An Evaluation of Existing Scientific Information and Issues for Future Research Report of the Health Effects Institute's Health Reseach Committee. Cambridge, MA. USA; 1987:3-69.
5. Maejima K, Suzuki T, Numata H, Maekawa A, Nagase S, Ishinishi N. Subchronic (12-week) inhalation toxicity study of methanol-fueled engine exhaust in rats. J Toxicol Environ Health 1994;41:315-327.
6. Poon R, Chu I, Bjarnason S. et al. Short-term inhalation toxicity of methanol. gasoline and methanol/ gasoline in the rat. Toxicol Ind Health. 1995;11:343.
7. Akland GG. Exposure of the general population to gasoline. Environ Health Perspect. 1993;101(suppl 6):27-32.
8. Tardif R, Goyal R, Brodeur J. Assessment of occupational health risk from multiple exposure: review of industrial solvent interaction and implication for biological monitoring of exposure. Toxicol Ind Health. 1992;8:37-52.
9. Alessio L, Apostoli P, Crippa M. Multiple exposure to solvents and metals. Occup Hyg 1994;1:127-151.
10. Ikeda M. Exposure to complex mixtures: implications for biological monitoring. Toxicol Lett. 1995;77:85-91.
11. Ogata M, Tomokuni K, Takatsuka Y. Urinary excretion of hippuric acid and m-or P-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylencasa test of exposure. Br J Ind Med. 1970;27:43-50.
12. Tardif R, Laparé S, Plaa GL, Brodeur J. Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in humans. Int Arch Occup Environ Health. 1991;63:279-284.
13. Tardif R, Plaa GL, Brodeur J. Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats. Can J Physiol Pharmacol 1992;70:385-393.
14. Tardif R, Laparé S, Krishnan K, Brodeur J. Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat. Toxicol Appl Pharmacol 1993;120:266-273.
15. Miller RR, Letts RL, Potts WJ, McKenna MJ. Improved methodology for generating controlled atmospheres. Am Ind Hyg Assoc J 1980;41:844-846.
16. Krishnan K, Clewell HJ III, Andersen ME. Physiologically based pharmacokinetic analysis of simple mixtures. Environ Health Perspect. 1994;102(suppl 9):151-155.
17. Krishnan K, Brodeur J. Toxic interactions among environmental pollutants corroborating laboratory observations with human experience. Environ Health Perspect. 1994;102(suppl 9):11-17.
18. Gargas ML, Burgess RJ, Voisard DE, Cason GH, Andersen ME. Partition coefficients of low molecular weight volatile chemicals in various tissues and liquids. Toxicol Appl Pharmacol. 1989;98:87-99.
19. Travis CC, Quillen JL, Arms AD. Pharmacokinetics of benzene. Toxicol Appl Pharmacol 1990;102: 400-420.
20. DiSanzo FP, Lowther CJ, Yoder RE, Lane JL. Automated simulated distillation of heavy petroleum fractions by packed column gas chromatography. J Chromatogr. Sci. 1988;26:39-41.
21. Toxicological Profile for Automotive Gasoline. Chicago, IL: Agency for Toxic Substances and Disease Registry. Public Health Service, U.S. Department of Health and Human Services. Centers for Disease Control; March 1993:56-61.
22. MacFarland MN. Designs and operational characteristics of inhalation exposure equipment. In: Salem H. ed. Inhalation Toxicology Research Methods. Applications and Evaluation. Occupational Safety and Health/12. New York: Dekker. 1987:93-120.
23. Johansson I, Ingelmann-Sundberg M. Benzene metabolism by ethanol-acetone, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res. 1988;48:5387-5390.
24. Lira J, Elovara R, Riihimaki V, Engstrom K. Metabolic interaction and disposition of methyl ethyl ketone and m-xylene in rats at single and repeated exposures. Xenobiotica 1991;21:53-65.
25. Nakajima T, Wang R, Elovaara E. et al. Monoclonal antibody directed characterization of cytochrome P-450 isoenzymes responsible for toluene metabolism in rat liver. Biochem Pharmacol. 1991;41:395-404.
26. 4) hepatotoxicity following exposure to inhaled methanol (MeOH). The Toxicologist. 1995;15:41.