Driving forces and the influence of the buffer composition on the complexation reaction between ibuprofen and HPCD

European Journal of Pharmaceutical Sciences

Volumn 20, Issue 2, 2003, Pages 197-200

  Perlovich, German L ^a,b   Skar, Merete ^a   Bauer Brandl, Annette ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

Author keywords

Complexation constant; Enthalpy; Entropy; Hydroxypropyl cyclodextrin; Ibuprofen; pH; Titration calorimetry

Indexed keywords

COMPLEXATION; COMPOSITION; ENTHALPY; PH EFFECTS;

CYCLODEXTRINS;

DRUG PRODUCTS;

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BUFFER; CITRIC ACID; IBUPROFEN; PHOSPHATE; PHOSPHORIC ACID; SODIUM;

ARTICLE; CALORIMETRY; COMPLEX FORMATION; DRUG STRUCTURE; ENERGY; ENTHALPY; ENTROPY; FORCE; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR MODEL; PH; PRIORITY JOURNAL; THERMODYNAMICS; TITRIMETRY;

EID: 0141447811     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(03)00180-5     Document Type: Article

References (11)

1. Briggner L.E., Wadsö I. Test and calibration processes for microcalorimeters with special reference to heat conduction instruments used with aqueous systems. J. Biochem. Biophys. Methods. 22:1991;101-118.
2. Connors K.A. The stability of cyclodextrin complexes in solution. Chem. Rev. 97:1997;1325-1357.
3. Junquera E., Aicart E. Potentiometric study of the encapsulation of ketoprophen by hydroxypropyl-β-cyclodextrin. Temperature, solvent, and salt effects. J. Phys. Chem. B. 101:1997;7163-7171.
4. Junquera E., Martin-Pastor M., Aicart E. Molecular encapsulation of flurbiprophen and/or ibuprophen by hydroxypropyl-β-cyclodextrin in aqueous solution. Potentiometric and molecular modeling studies. J. Org. Chem. 63:1998;4349-4358.
5. Mura P., Bettinetti G.P., Manderioli A., Faucci M.T., Bramanti G., Sorrenti M. Interaction of ketoprofen and ibuprofen with β-cyclodextrins in solution and in the solid state. Int. J. Pharm. 166:1998;189-203.
6. Oh I., Lee M.-Y., Lee Y.-B., Shin S.-C., Park I. Spectroscopic characterization of ibuprofen/2-hydroxypropyl-β-cyclodextrin inclusion complex. Int. J. Pharm. 175:1998;215-223.
7. Otero-Espinar F.J., Anguiano-Igea S., Garsia-Gonzalez N., Vila-Jato J.L., Blanco-Mendez J. Interaction of naproxen with β-cyclodextrin in solution and in the solid state. Int. J. Pharm. 79:1992;149-157.
8. Szejtli, J., 1988. Cyclodextrin Technology. Kluwer, Dordrecht.
9. Uekama K., Hirayama F., Irie T. Cyclodextrin drug carrier systems. Chem. Rev. 98:1998;2045-2076.
10. Van der Jagt D.L., Killian F.L., Bender M.L. Cycloamyloses as enzyme models. Effects of inclusion complex formation on intramolecular participation. J. Am. Chem. Soc. 92:1970;1016.
11. Wenz G., Höfler S., Wehrle S., Schneider M. Inclusion of pharmaceutical drugs in cyclodextrins as measured by titration microcalorimetry. Polym. Preprints. 39:1998;202-203.