Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 821-823

  Muller H C ^a   Meier, C ^a   Balzarini, J ^b   Reinstein, J ^c  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE DERIVATIVE; PHOSPHOTRANSFERASE; THYMIDINE PHOSPHATE; THYMIDYLATE KINASE; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE DERIVATIVE;

CONFERENCE PAPER; DRUG METABOLISM; DRUG STRUCTURE; ENZYME KINETICS; ENZYME SUBSTRATE;

BIOTRANSFORMATION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; KINETICS; NUCLEOSIDE-PHOSPHATE KINASE; NUCLEOTIDES; REVERSE TRANSCRIPTASE INHIBITORS; THYMIDINE MONOPHOSPHATE; THYMINE NUCLEOTIDES; ZIDOVUDINE;

EID: 0141425595     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022662     Document Type: Conference Paper

References (2)

1. Lavie, A.; Schlichting, I.; Vetter, I.R.; Konrad, M.; Reinstein, J.; Goody, R.S. The bottleneck in AZT activation. Nature Medicine 1997, 3, 922-924.
2. Meier, C. cycloSal-pronucleotides - design of chemical trojan horses. Mini Reviews Med. Chem. 2002, 2, 219-234.