Intracortical inhibition and facilitation are impaired in patients with early Parkinson's disease: A paired TMS study

European Journal of Neurology

Volumn 10, Issue 4, 2003, Pages 385-389

  Bareš, Martin ^a   Kanovsky P ^a   Klajblova H ^a   Rektor, I ^a  

^a ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

Author keywords

Basal ganglia; Intracortical facilitation; Intracortical inhibition; Motor cortex; Paired transcranial magnetic stimulation; Parkinson's disease

Indexed keywords

ANTIPARKINSON AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; FACILITATION; HEMISPHERE; HUMAN; MOTOR CORTEX; PARKINSON DISEASE; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; SKELETAL MUSCLE; TRANSCRANIAL MAGNETIC STIMULATION; ADULT; AGED; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; CONDITIONING; ELECTROSTIMULATION; FEMALE; HEMISPHERIC DOMINANCE; MAGNETISM; MALE; METHODOLOGY; MIDDLE AGED; NERVE CELL INHIBITION; PHYSIOLOGY; REACTION TIME; TIME;

ADULT; AGED; CASE-CONTROL STUDIES; CONDITIONING (PSYCHOLOGY); ELECTRIC STIMULATION; EVOKED POTENTIALS, MOTOR; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MAGNETICS; MALE; MIDDLE AGED; MOTOR CORTEX; NEURAL INHIBITION; PARKINSON DISEASE; REACTION TIME; SENSORY THRESHOLDS; TIME FACTORS;

EID: 0043288020     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1046/j.1468-1331.2003.00610.x     Document Type: Article

References (20)

1. Abbruzzese G, Assini A, Buccolieri A, Schieppati M, Trompetto C (1999). Comparison of intracortical inhibition and facilitation in distal and proximal arm muscles in humans. J Physiol (Lond) 514:895-903.
2. Berardelli A, Rona S, Inghilleri M, Manfredi M (1996). Cortical inhibition in Parkinson's disease. A study with paired magnetic stimulation. Brain 119:71-77.
3. Civardi C, Cantello R, Asselman P, Rothwell JC (2001). Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans. Neuroimage 14:1444-1453.
4. Cunnington R, Iansek R, Thickbroom GW et al. (1996). Effects of magnetic stimulation over supplementary motor area on movement in Parkinson's disease. Brain 119:815-822.
5. Hanajima R, Ugawa Y, Terao Y, Ogata K, Kanazawa I (1996). Ipsilateral cortico-cortical inhibition of the motor cortex in various neurological disorders. J Neurol Sci 140:109-116.
6. Kujirai T, Caramia MD, Rothwell JC et al. (1993). Cortico-cortical inhibition in human motor cortex. J Physiol 471:501-519.
7. Liepert J, Schwenkreis P, Tegenthoff M, Malin J-P (1997). The glutamate antagonist Riluzole suppresses intracortical facilitation. J Neurol Trans 104:1207-1214.
8. Liepert J, Classen J, Cohen LG, Hallett M (1998). Task-dependent changes of intracortical inhibition. Exp Brain Res 118:421-426.
9. Manganotti P, Bortolomasi M, Zanette G, Pawelzik T, Giacopuzzi M, Fiaschi A (2001). Intravenous clomipramine decreases excitability of human motor cortex. A study with paired magnetic stimulation. J Neurol Sci 184:27-32.
10. Pierantozzi M, Palmieri MG, Marciani MG, Bernardi G, Giacomini P, Stanzione P (2001). Effect of apomorphine on cortical inhibition in Parkinson's disease patients: a transcranial magnetic stimulation study. Exp Brain Res 141:52-62.
11. Priori A, Berardelli A, Inghilleri M, Accornero N, Manfredi M (1994). Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism. Brain 117:317-323.
12. Ridding MC, Inzelberg R, Rothwell JC (1995). Changes in excitability of motor cortical circuitry in patients with Parkinson's disease. Ann Neurol 37:181-188.
13. Strafella AP, Valzania F, Nassetti SA et al. (2000). Effects of chronic levodopa and pergolide treatment on cortical excitability in patients with Parkinson's disease: a transcranial magnetic stimulation study. Clin Neurophysiol 111:1198-1202.
14. Ward CD, Gibb WR (1990). Research diagnostic crieria for Parkinson's disease. Adv Neurol 53:245-249.
15. Ziemann U (1999). Intracortical inhibition and facilitation in the conventional paired TMS paradigm. In: Paulus W, Hallett M, Rossini PM, eds. Transcranial Magnetic Stimulation. Electroencephalogr Clin Neurophysiol Suppl 51:127-136.
16. Ziemann U, Bruns D, Paulus W (1996a). Enhancement of human motor cortex inhibition by the dopamine receptor agonist pergolide: evidence from transcranial magnetic stimulation. Neurosci Lett 208:187-190.
17. Ziemann U, Lönnecker S, Steinhoff BJ, Paulus E (1996b). Effects of antiepileptic drugs on motor cortex excitability in humans: a transcranial magnetic stimulation study. Ann Neurol 40:367-378.
18. Ziemann U, Rothwell JC, Ridding MC (1996c). Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol (Lond) 496:873-881.
19. Ziemann U, Tergau F, Bruns D, Baudewig J, Paulus W (1997). Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs. Electroencephalogr clin Neurophysiol 105:430-437.
20. Ziemann U, Chen R, Cohen LG, Hallett M (1998). Dextromethorphan decreases the excitability of the human motor cortex. Neurology 51:1320-1324.