Nerve compound action current (NCAC) measurements and morphometric analysis in the proximal segment after nerve transection and repair in a rabbit model

Journal of the Peripheral Nervous System

Volumn 8, Issue 2, 2003, Pages 108-115

  Walbeehm, Erik T ^b   Dudok Van Heel, E B Michiel ^c   Kuypers, Paul D L ^c   Terenghi, Giorgio ^a   Hovius, Steven E R ^c  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c NONE

Author keywords

Histology; Magnetic neurography; Myelinated axon count; Nerve regeneration; Proximal segment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; MYELINATED NERVE; NERVE POTENTIAL; NERVE REGENERATION; NERVE TRANSECTION; NEUROGRAPHY; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0043287307     PISSN: 10859489     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1529-8027.2003.03014.x     Document Type: Article

References (28)

1. Cragg B, Thomas P (1961). Changes in conduction velocity and fibre size proximal to nerve lesions. J Physiol 157:315-327.
2. Davis L, Gordon T, Hoffer J, Jhamandas J, Stein R (1978). Compound action potentials recorded from mammalian peripheral nerves following ligation or resuturing. J Physiol 285:543-559.
3. Germana G, Muglia U, Santoro M, Abbate F, Laura R, Gugliotta M, Vita G, Ciriaco E (1992). Morphometric analysis of sciatic nerve and its main branches in the rabbit. Biol Struct Morphog 4:11-15.
4. Gillespie M, Stein R (1983). The relationship between axon diameter, myelin thickness and conduction velocity during atrophy of mammalian peripheral nerves. Brain Res 259:41-56.
5. Goldstein M, Cooper H, Bruce J, Carden M, Lee V, Schlaepfer W (1987). Phosphorylation of neurofilament proteins and chromatolysis following transection of rat sciatic nerve. J Neurosci 7:1586-1594.
6. Gutman E, Sanders F (1943). Recovery of fibre numbers and diameters in the regeneration of peripheral nerves. J Physiol 101:489-518.
7. Hoffman P (1988). Distinct roles, of neurofilament and tubulin gene expression in axonal growth. Ciba Found Symp 138:192-204.
8. Hoffman P, Cleveland D (1988). Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A 85:4530-4533.
9. Hoffman P, Cleveland D, Griffin J, Landes P, Cowan N, Price D (1987). Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A 84:3472-3476.
10. Hoffman P, Griffin J, Gold B, Price D (1985a). Slowing of neurofilament transport and the radial growth of developing nerve fibers. J Neurosci 5:2920-2929.
11. Hoffman P, Thompson G, Griffin J, Price D (1985b). Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers. J Cell Biol 101:1332-1340.
12. Horch K, Lisney S (1981). On the number and nature of regenerating myelinated axons after lesions of cutaneous nerves in the cat. J Physiol (Lond) 313:275-286.
13. Kanaya F, Firrell J, Breidenbach W (1996). Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration. Plast Reconstr Surg 98:1264-1271.
14. Kuypers PD, Gielen FL, Wai RT, Hovius SE, Godschalk M, van Egeraat JM (1993). A comparison of electric and magnetic compound action signals as quantitative assays of peripheral nerve regeneration. Muscle Nerve 16:634-641.
15. Kuypers PD, van Egeraat JM, Dudok v Heel M, van Briemen LJ, Godschalk M, Hovius SE (1998a). A magnetic evaluation of peripheral nerve regeneration: I. The discrepancy between magnetic and histologic data from the proximal segment. Muscle Nerve 21:739-749.
16. Kuypers PD, van Egeraat JM, Godschalk M, Hovius SE (1995). Loss of viable neuronal units in the proximal stump as possible cause for poor function recovery following nerve reconstructions. Exp Neurol 132:77-81.
17. Kuypers PD, van Egeraat JM, van Briemen LJ, Godschalk M, Hovius SE (1998b). A magnetic evaluation of peripheral nerve regeneration: II. The signal amplitude in the distal segment in relation to functional recovery. Muscle Nerve 21:750-755.
18. Kuypers PD, Walbeehm ET, Heel MD, Godschalk M, Hovius SE (1999). Changes in the compound action current amplitudes in relation to the conduction velocity and functional recovery in the reconstructed peripheral nerve. Muscle Nerve 22:1087-1093.
19. Roth B, Wikswo JP (1985). The magnetic field of a single axon. A comparison of theory and experiment. Biophys J 48: 93-109.
20. Sterne G, Brown R, Green C, Terenghi G (1997). Neurotrophin-3 delivered locally via fibronectin mats enhances peripheral-nerve regeneration. Eur J Neurosci 9:1388-1396.
21. Wijesinghe R, Gielen F, Wikswo JP (1991a). A model for compound action potentials and currents in a nerve bundle. I: The forward calculation. Ann Biomed Eng 19:43-72.
22. Wijesinghe R, Wikswo JP (1991). A model for compound action potentials and currents in a nerve bundle. II: A sensitivity analysis of model parameters for the forward and inverse calculations. Ann Biomed Eng 19:73-96.
23. Wikswo J, Barach J (1980). An estimate of the steady magnetic field strength required to influence nerve conduction. IEEE Trans Biomed Eng 27:722-723.
24. Wikswo J, Barach J, Freeman J (1980). Magnetic field of a nerve impulse: first measurements. Science 208:53-55.
25. Wikswo JP (1982). Improved instrumentation for measuring the magnetic field of cellular action currents. Rev Sci Instrum 53:1846-1850.
26. Wikswo JP, Roth B (1988). Magnetic determination of the spatial extent of a single cortical current source: a theoretical analysis. Electroencephalogr Clin Neurophysiol 69:266-276.
27. Wikswo JP, Samson P, Giffard R (1983). A low-noise low input impedance amplifier for magnetic measurements of nerve action currents. IEEE Trans Biomed Eng 30:215-221.
28. Wikswo JP, van Egeraat J (1991). Cellular magnetic fields: fundamental and applied measurements on nerve axons, peripheral nerve bundles, and skeletal muscle. J Clin Neurophysiol 8:170-188.