Changing trends in the epidemiology of pediatric lead exposure: Interrelationship of blood lead and ZPP concentrations and a comparison to the US population

Therapeutic Drug Monitoring

Volumn 25, Issue 4, 2003, Pages 415-420

  Soldin, Offie Porat ^a,b   Pezzullo, John C ^c   Hanak, Brian ^d   Miller, Maureen ^d   Soldin, Steven J ^a,d,e  

^a Soldin Res and Consultants Inc   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^d GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^e GEORGETOWN UNIVERSITY   (United States)

Author keywords

Adolescent; Adverse effects; Environmental exposure; Environmental monitoring; Epidemiology; Human; Iron deficiency anemia; Lead poisoning; Pediatric; Prevention and control; Reference values; Urban; Zinc protoporphyrin

Indexed keywords

LEAD; PROTOPORPHYRIN ZINC;

ADOLESCENT; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CHILD; COMPARATIVE STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; FLUOROMETRY; HEMATOFLUOROMETRY; HUMAN; LEAD BLOOD LEVEL; LEAD POISONING; MALE; PEDIATRIC HOSPITAL; PRIORITY JOURNAL; REFERENCE VALUE; UNITED STATES; ZINC BLOOD LEVEL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; DISTRICT OF COLUMBIA; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LEAD; LEAD POISONING; MALE; PROTOPORPHYRINS; TIME FACTORS; UNITED STATES;

EID: 0043269299     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-200308000-00001     Document Type: Article

References (23)

1. Centers for Disease Control and Prevention. Preventing Lead Poisoning in Young Children: A Statement by the Centers for Disease Control. Atlanta: US Dept of Health and Human Services, 1991.
2. Marsh WL Jr, Nelson DP, Koenig HM. Free erythrocyte protoporphyrin (FEP) I. Normal values for adults and evaluation of the hematofluorometer. Am J Clin Pathol. 1983;79:655-660.
3. Labbe RF, Vreman HJ, Stevenson DK. Zinc protoporphyrin: A metabolite with a mission. Clin Chem. 1999;45:2060-2072.
4. Marsh WL Jr, Nelson DP, Koenig HM. Free erythrocyte protoporphyrin (FEP) II. The FEP test is clinically useful in classifying microcytic RBC disorders in adults. Am J Clin Pathol. 1983;79:661-666.
5. Kitajima H, Kaneko T, Akatsuka J. The measurement of erythrocyte zinc protoporphyrin/heme ratio in various anemias in childhood. Rinsho Ketsueki. 1992;33:1199-1203.
6. Lamola AA, Eisinger J, Blumberg WE. Erythrocyte protoporphyrin/heme ratio by hematofluorometry. Clin Chem. 1980;26:677-678.
7. Labbe RF, Finch CA, Smith NJ, et al. Erythrocyte protoporphyrin/heme ratio in the assessment of iron status. Clin Chem. 1979;25:87-92.
8. Stockman JA, Weiner LS, Simon GE, et al. The measurement of free erythrocyte porphyrin (FEP) as a simple means of distinguishing iron deficiency from beta-thalassemia trait in subjects with microcytosis. J Lab Clin Med. 1975;85:113-119.
9. Vogeser M, Jacob K, Zachoval R. Erythrocyte protoporphyrins in hepatitis C viral infection. Clin Biochem. 2000;33:387-391.
10. Piomelli S, Davidow S. Guinee VF, et al. The FEP (free erythrocyte porphyrins) test: a screening micromethod for lead poisoning. Pediatrics. 1973;51:254-259.
11. Davidow B, Slavin G, Piomelli S. Measurement of free erythrocyte protoporphyrin in blood collected on filter paper as a screening test to detect lead poisoning in children. Ann Clin Lab Sci. 1976;6:209-213.
12. Soldin OP, Hanak B. Soldin SJ. Blood lead concentrations in children: new ranges. Clin Chim Acta. 2003;327:109-113.
13. Soldin OP, Miller M, Soldin SJ. Pediatric reference ranges for zinc protoporphyrin. Clin Biochem. 2003;36:21-25.
14. Rifai N, Cohen G, Wolf M, et al. Incidence of lead poisoning in young children from inner-city, suburban, and rural communities. Ther Drug Monit. 1993;15:71-74.
15. Hoffmann RG. Statistics in the practice of medicine. JAMA. 1963;185:864-873.
16. Lanphear BP, Dietrich KN, Auinger P, et al. Subclinical lead toxicity in U.S. children and adolescents. Pediatr Res. 2000;152A.
17. Schwartz J. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res. 1994;65:42-55.
18. MMWR. Blood lead levels-United States, 1988-1991. MMWR Morbid Mortal Wkly Rep. 1994:43:545-548.
19. MMWR. Update. blood lead levels - United States, 1991-1994. MMWR Morbid Mortal Wkly Rep. 1997;46:141-146.
20. Brody DJ, Pirkle JL, Kramer RA, et al. Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991). JAMA. 1994;272:277-283.
21. Centers for Disease Control and Prevention. National Report on Human Exposure to Environmental Chemicals. National Center for Environmental Health (Lead CAS no. 7439-92-1). Atlanta: CDC, 2002.
22. Pirkle JL, Kaufmann RB, Brody DJ, et al. Exposure of the U.S. population to lead, 1991-1994. Environ Health Perspect. 1998;106:745-750.
23. Piomelli S, Seaman C, Zullow D, et al. Threshold for lead damage to heme synthesis in urban children. Proc Natl Acad Sci USA. 1982;79:3335-3339.