Thromboembolic complications related to indwelling central venous catheters in children

Current Opinion in Oncology

Volumn 15, Issue 4, 2003, Pages 289-292

  Freytes, César O ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Catheter; Catheterization; Central venous; Child; Indwelling; Neoplasm; Thrombosis

Indexed keywords

ASPARAGINASE; DALTEPARIN; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; WARFARIN;

ANTIPHOSPHOLIPID SYNDROME; CANCER PATIENT; CATHETERIZATION; CENTRAL VENOUS CATHETER; CHILD; CLINICAL TRIAL; DISEASE ASSOCIATION; DOSE RESPONSE; HUMAN; HYPERCOAGULABILITY; INCIDENCE; INDWELLING CATHETER; LOW DRUG DOSE; POPULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; RISK; SIDE EFFECT; THROMBOEMBOLISM;

CATHETERIZATION, CENTRAL VENOUS; CATHETERS, INDWELLING; CHILD; HUMANS; NEOPLASMS; THROMBOEMBOLISM;

EID: 0043240372     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-200307000-00002     Document Type: Review

References (14)

1. Freytes CO: Vascular access problems revisited: the Multinational Association of Supportive Care in Cancer (MASCC) experience. Support Care Cancer 1998, 6:13-19.
2. Andrew M, Michele D, Adams M, et al.: Venous thromboembolic complications (VTE) in children: first analyses of the Canadian Registry of VTE. Blood 1994, 83:1251-1257.
3. Molinari AC, Castagnola E, Mazzola C, et al.: Thromboembolic complications related to indwelling central venous catheters in children with oncological/haematological diseases: a retrospective study of 362 catheters. Support Care Cancer 2001, 9:539-544.
4. Glaser DW, Medeiros D, Rollins N, et al.: Catheter-related thrombosis in children with cancer. J Pediatr 2001, 138:255-259.
5. Fratino G, Molinari AC, Mazzola C, et al.: Prospective study of indwelling central venous catheter-related complications in children with Broviac or clampless valved catheters. J Pediatr Hematol Oncol 2002, 24:657-661. A prospective comparison of two different types of ICVCs. Although small, this study addresses an important question regarding the optimal use of central venous catheters in children with cancer.
6. Sutherland DE, Weitz IC, Liebman HA: Thromboembolic complications of cancer: epidemiology, pathogenesis, diagnosis and treatment. Am J Hematol 2003, 72:43-52. An excellent review of the epidemiology, pathogenesis, diagnosis, and treatment of thromboembolic complications of cancer including catheter-related thrombosis in patients with cancer.
7. Ruud E, Holmstrom H, Natvig S, et al.: Prevalence of thrombophilia and central venous catheter-associated neck vein thrombosis in 41 children with cancer: a prospective study. Med Pediatr Oncol 2002, 38:405-410. A current, well-designed study that focuses on the influence of thrombophilia on catheter-related thrombosis in children with cancer.
8. Mitchell LG: PARKAA Group: A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line treated with asparaginase. Cancer 2003, 97:508-516. A well-executed prospective multicenter trial analyzes the risk of thrombosis of a well-defined population of children with an ICVC treated in a uniform fashion. A good example of the type of studies needed to clearly define catheter-related complications in patients with cancer.
9. Hong AP, Cook DJ, Sigouin CS, et al.: Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood 2003, 101:3049-3051. This is an excellent study that clearly establishes that a localizing vascular injury owing to an ICVC and a systemic hypercoagulability disorder interact to explain upper extremity deep vein thrombosis.
10. Joffe HV, Goldhaber SZ: Upper-extremity deep vein thrombosis. Circulation 2002, 106:1874-1880. This is an authoritative review of a frequent complication of ICVCs.
11. Bern MM, Lokich JJ, Wallach SR, et al.: Very low doses of warfarin can prevent thrombosis in central venous catheters. A randomized prospective. Ann Intern Med 1990, 112:423-428.
12. Monreal M, Alastrue A, Rull M, et al.: Upper extremity deep venous thrombosis in cancer patients with venous access devices: prophylaxis with a low molecular weight heparin (Fragmin). Thromb Haemost 1996, 75:251-253.
13. Mismetti P, Mille D, Laporte S, et al.: Low-molecular weight heparin (nadroparin) and very low doses of warfarin in the prevention of upper extremity thrombosis in cancer patients with indwelling long-term central venous catheters: a pilot randomized trial. Haematologica 2003, 88:67-73. This study addresses the use of low molecular weight heparin as prophylaxis for catheter-related thrombosis with emphasis in the cost-benefit ratio.
14. Masci G, Magagnoli M, Zucali PA, et al.: Minidose warfarin prophylaxis for catheter associated thrombosis in cancer patients: can it be safely associated with fluorouracil-based chemotherapy? J Clin Oncol 2003, 21:736-739. A study of practical importance documents a high incidence of coagulation abnormalities in patients with cancer treated with fluorouracil who also received low-dose warfarin prophylaxis for catheter-related thrombosis.