Local and systemic chemotherapy with taurolidine and taurolidine/heparin in colon cancer-bearing rats undergoing laparotomy

Clinical and Experimental Metastasis

Volumn 20, Issue 5, 2003, Pages 387-394

  Braumann, Chris ^a   Ordemann, Jürgen ^a   Kilian, Maik ^a   Wenger, Frank A ^a   Jacobi, Christoph A ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Heparin; Laparotomy; Leukocytes; Rats; Taurolidine; Tumor growth

Indexed keywords

HEPARIN; TAUROLIDINE;

ABDOMINAL INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER SIZE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DRUG EFFECT; DRUG INSTILLATION; LAPAROTOMY; LEUKOCYTE COUNT; LEUKOCYTOSIS; LEUKOPENIA; MALE; METASTASIS; NONHUMAN; POSTOPERATIVE COMPLICATION; RANDOMIZATION; RAT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY WEIGHT; CELL DIVISION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; LEUKOCYTES; LEUKOCYTOSIS; LEUKOPENIA; MALE; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; RANDOM ALLOCATION; RATS; TAURINE; TEMPERATURE; THIADIAZINES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0043238941     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025402919341     Document Type: Article

References (28)

1. Iwanaka T, Arya G, Ziegler MM. Mechanism and prevention of port-site tumor recurrence after laparoscopy in a murine model. J Pediatr Surg 1998; 33: 457-61.
2. Neuhaus SJ, Watson DI, Ellis T et al. Efficacy of cytotoxic agents for the prevention of laparoscopic port-site metastases. Arch Surg 1998; 133: 762-6.
3. Neuhaus SJ, Watson DI, Ellis T et al. Influence of cytotoxic agents on intraperitoneal tumor implantation after laparoscopy. Dis Colon Rectum 1999; 42: 10-5.
4. Stuntz M, Wilmoth G, Ong J et al. Use of intraperitoneal 5-fluorouracil and chlorhexidine for prevention of recurrence of perforated colorectal carcinoma in a rat model. Dis Colon Rectum 1997; 40: 1085-8.
5. Wu JS, Pfister SM, Ruiz MB et al. Local treatment of abdominal wound reduces tumor implantation. J Surg Oncol 1998; 69: 9-13.
6. Jacobi CA, Sabat R, Ordemann J et al. Peritoneale Instillation von Taurolidin und Heparin zur Verhinderung von intraperitonealem Tumorwachstum und Trokarmetastasen bei laparoskopischen Operationen im Rattenmodell. Langenbecks Arch Chir 1997; 382: 31-6.
7. McCourt M, Wang JH, Sookhai S et al. Taurolidine inhibits tumor cell growth in vitro and in vivo. Ann Surg Oncol 2000; 7: 685-91.
8. Bedrosian I, Sofia RD, Wolff SM et al. Taurolidine. An analogue of the amino acid taurine, suppresses interleukin-1 and tumor necrosis factor synthesis in human peripheral blood mononuclear cells. Cytokine 1991; 3: 568-75.
9. Lanfrancone L, Boraschi D, Ghiara P. Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor, granulocyte-monocyte CSF, macrophage CSF, IL-1 and IL,-2) and are activated and stimulated to grow by IL-1. Blood 1992; 80: 2835-42.
10. Yanagisawa M, Imai H, Fukushima Y. Effects on tumour necrosis factor alpha and interleukin 1 beta on the proliferation of cultured glomerular epithelial cells. Virchows Arch 1994; 426: 581-6.
11. Jacobi CA, Wildbrett P, Volk T et al. Influence of different gases and intraperitoneal instillation of antiadherent or cytotoxic agents on peritoneal tumor cell growth and implantation with laparoscopic surgery in a rat model. Surg Endosc 1999; 13: 1021-5.
12. Jacobi CA, Peter FJ, Wenger FA et al. New therapeutic strategies to avoid intra- and extraperitoneal metastases during laparoscopy: Results of a tumor model in the rat. Dig Surg 1999; 16: 393-5.
13. Goldstein DS, Lu ML, Hattori T. Inhibition of peritoneal tumor cell implantation: Model for laparoscopic cancer surgery. J Endourol 1993; 7: 237-41.
14. Knight BI, Skellern GG, Browne MK et al. Peritoneal absorption of the antibacterial and antiendotoxin taurolidine in peritonitis. Br J Clin Pharm 1981; 12: 695-9.
15. Braumann C, Ordemann J, Wildbrett P et al. Influence of intraperitoneal and systemic application of taurolidine and taurolidine/heparin during laparoscopy on intraperitoneal and subcutaneous tumor growth in rats. Clin Exp Metastasis 2001; 18(7): 547-52.
16. Jacobi CA, Ordemann J, Bühm B et al. The influence of laparotomy and laparoscopy on tumor growth in a rat model. Surg Endosc 1997; 11: 618-21.
17. Lee SW, Whelan RL, Southall JC et al. Abdominal wound tumor recurrence after open and laparoscopic-assisted splenectomy in a murine model. Dis Colon Rectum 1998; 41: 824-31.
18. Neuhaus SJ, Ellis T, Jamieson GG et al. Experimental study of the effect of intraperitoneal heparin on turnout implantation following laparoscopy. Br J Surg 1999; 86: 400-4.
19. Gorman SP, McCafferty DF, Woolfson AD et al. Reduced adherence of micro-organisms to human mucosal epithelial cells following treatment with taurolin, a novel antimicrobial agent. J Appl Bacteriol 1987; 62: 315-20.
20. Calabresi P, Goulette FA, Darnowski JW. Taurolidine: Cytotoxic and mechanistic evaluation of a novel antineoplastic agent. Cancer Res. 2001; 61: 6816-21.
21. Pfirrmann RW. Einführung und Übersicht. In: Brückner WL und Pfirrmann RW, Taurolin. Ein neues Konzept zur antimikrobiellen Chemotherapie chirurgischer Infektionen. Munich: Urban und Schwarzenberg 1985; 3-23.
22. Gill WB, Jones KW, Rugierro KJ. Protective effects of heparin and other sulfated glycosaminoglycans on crystal adhesion to injured urothelium. J Urol 1982; 127: 151-4.
23. Solberg R, Scholz T, Videm V et al. Heparin coating reduces cell activation and mediator release in an in vitro venovenous bypass model for liver transplantation. Transpl Int 1998; 11: 252-8.
24. Dudas J, Ramadori G, Knittel T et al. Effect of heparin and liver heparan sulphate on interaction of HepG2-derived transcription factors and their cis-acting elements: Altered potential of hepatocellular carcinoma heparan sulphate. Biochem J 2000; 350: 245-51.
25. Gutt CN, Kim ZG, Gessmann T et al. Hepatic tumour spread of colorectal cancer in a laparoscopic animal model. Surg Endosc 2000; 14: 448-51.
26. Little D, Regan M, Keane RM et al. Perioperative immune modulation. Surgery 1993; 114: 87-91.
27. Staubach KH. Adjuvante Peritonitistherapie mit Taurolidin Modulation der Mediator-freisetzung. Langenbecks Arch Chir 1997; 382: 26-30.
28. Da Costa ML, Redmond HP, Bouchier-Hayes DJ. Taurolidine improves survival by abrogating the accelerated development and proliferation of solid tumors and development of organ metastases from circulating tumor cells released following surgery. J Surg Res 2001; 101: 111-9.