You may live to the age of more than 100 years even if you are homozygous for a haemochromatosis gene mutation

European Journal of Clinical Investigation

Volumn 33, Issue 9, 2003, Pages 830-831

  Piippo, K ^a   Louhija, J ^a   Tilvis, R ^a   Kontula, Kimmo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ALLELE; CLINICAL FEATURE; ENVIRONMENTAL FACTOR; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC EPIDEMIOLOGY; HEALTH STATUS; HEMOCHROMATOSIS; HEREDITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LETTER; NUTRITIONAL STATUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; DNA; FEMALE; FINLAND; HEMOCHROMATOSIS; HOMOZYGOTE; HUMANS; LONGEVITY; MALE; MIDDLE AGED; MUTATION;

EID: 0043234486     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2003.01210.x     Document Type: Letter

References (9)

1. van Aken MO, de Craen AJM, Gussekloo J, Hanifi Moghaddam P, Vandenbroucke JP, Heijmans BT et al. No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden study. Eur J Clin Invest 2002;32:750-4.
2. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet 1996;13:399-408.
3. Beutler E. Genetic irony beyond haemochromatosis: clinical effects of HLA-H mutations. Lancet 1997;349:296-7.
4. Louhija J, Miettinen HE, Kontula K, Tikkanen MJ, Miettinen TA, Tilvis RS. Ageing and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler Thromb 1994;14:1084-9.
5. Halme L, Heliö T, Mäkinen J, Höckerstedt K, Färkkilä M, Piippo K et al. HFE haemochromatosis gene mutations in liver transplant patients. Scand J Gastroenterol 2001;8:881-5.
6. Bomford A. Genetics of haemochromatosis. Lancet 2002;360:1673-81.
7. Beutler E. Penetrance in hereditary hemochromatosis. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood 2003;101:3347-50.
8. Willis G, Wimperis JZ, Smith KC, Fellows IW, Jennings BA. Haemochromatosis gene C282Y homozygotes in an elderly male population. Lancet 1999;354:221-2.
9. Steinberg KK, Cogswell ME, Chang JC, Caudill SP, McQuillan GM, Bowman BA et al. Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States. JAMA 2001;285:2216-22.