Scaling of mutational effects in models for pleiotropy

Genetics

Volumn 164, Issue 3, 2003, Pages 1221-1228

  Wingreen, Ned S ^a   Miller, Jonathan ^a   Cox, Edward C ^b  

^a NEC LABORATORIES AMERICA   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ARTICLE; BIOLOGICAL MODEL; GENE LOCUS; GENE MUTATION; GENETIC CONSERVATION; GENETIC HETEROGENEITY; GENETIC PARAMETERS; GENETIC SELECTION; GENETIC VARIABILITY; MICROBIAL GENETICS; MOLECULAR EVOLUTION; MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; PHENOTYPE; PLEIOTROPY; POPULATION GENETICS; POPULATION MODEL; PRIORITY JOURNAL; PROBABILITY; PROTEIN FUNCTION; PROTEIN STRUCTURE; THEORETICAL MODEL;

GENETICS, POPULATION; MODELS, GENETIC; MUTATION; PHENOTYPE; SELECTION (GENETICS);

EID: 0043210647     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. ANCEL, L. W., and W. FONTANA, 2000 Plasticity, evolvability, and modularity in RNA. J. Exp. Zool. 288: 242-283.
2. BÜRGER, R., 1988 Perturbations of positive semigroups and applications to population genetics. Math. Z. 197: 259-272.
3. BÜRGER, R., 2000 The Mathematical Theory of Selection, Recombination, and Mutation. John Wiley & Sons, New York.
4. COPPERSMITH, S. N., R. D. BLANK and L. P. KADANOFF, 1999 Analysis of a population genetics model with mutation, selection, and pleiotropy. J. Stat. Phys. 97: 429-457.
5. EIGEN, M., 1971 Selforganization of matter and the evolution of biological macromolecules. Naturwissenschaften 58: 465-523.
6. EIGEN, M., J. McCASKILL and P. SCHUSTER, 1988 Molecular quasispecies. J. Phys. Chem. 92: 6881-6891.
7. FISHER, R. A., 1958 The Genetical Theory of Natural Selection, Ed. 2. Dover Publications, New York.
8. GHAEMMAGHAMI, S., and T. G. OAS, 2001 Quantitative protein stability measurement in vivo. Nat. Struct. Biol. 8: 879-882.
9. HARTWELL, L. H., J. J. HOPFIELD, S. LEIBLER and A. W. MURRAY, 1999 From molecular to modular cell biology. Nature 402: C47-C52.
10. IMHOF, M., and C. SCHLÖTTERER, 2001 Fitness effects of advantageous mutations in evolving Escherichia coli populations. Proc. Natl. Acad. Sci. USA 98: 1113-1117.
11. KIMURA, M., 1979 Model of effectively neutral mutations in which selective constraint is incorporated. Proc. Natl. Acad. Sci. USA 76: 3440-3444.
12. KINGMAN, J. F. C., 1978 A simple model for the balance between selection and mutation. J. Appl. Prob. 15: 1-12.
13. LIM, W. A., and R. T. SAUER, 1989 Alternative packing arrangements in the hydrophobic core of lambda repressor. Nature 339: 31-36.
14. LITTLE, J. W., D. P. SHEPLEY and D. W. WERT, 1999 Robustness of a gene regulatory circuit. EMBO J. 18: 4299-4307.
15. MATTHEWS, B. W., 1995 Studies on protein stability with T4 lysozyme. Adv. Prot. Chem. 46: 249-278.
16. OHTA, T., and J. H. GILLESPIE, 1996 Development of neutral and nearly neutral theories. Theor. Popul. Biol. 49: 128-142.
17. ORR, H. A., 2000 Adaptation and the cost of complexity. Evolution 54: 13-20.
18. SHAW, R. G., D. L. BYERS and E. DARMO, 2000 Sponmneous mutational effects on reproductive traits of Arabidopsis thaliana. Genetics 155: 369-378.
19. TURELLI, M., 1984 Heritable genetic variation via mutation-selection balance: Lerch's Zeta meets the abdominal bristle. Theor. Popul. Biol. 25: 138-193.
20. TURELLI, M., 1985 Effects of pleiotropy on predictions concerning mutation-selection balance for polygenic traits. Genetics 111: 165-195.
21. WAGNER, G. P., and J. MEZEY, 2000 Modeling the evolution of genetic architecture: a continuum of alleles model with pairwise A x A epistasis. J. Theor. Biol. 203: 163-175.
22. WAGNER, G. P., C. H. CHIN and T. F. HANSEN, 1999 Is Hsp90 a regulator of evolvability? J. Exp. Zool. 285: 116-118.
23. WAXMAN, D., and J. R. PECK, 1998 Pleiotropy and the preservation of perfection. Science 279: 1210-1213.
24. WEISS, K. M., and S. M. FULLERTON, 2000 Phenogenetic drift and the evolution of genotype-phenotype relationships. Theor. Popul. Biol. 57: 187-195.
25. WLOCH, D. M., K. SZAFRANIEC, R. H. BORTS and R. KORONA, 2001 Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae. Genetics 159: 441-452.
26. ZHANG, X.-S., J. WANG and W. G. HILL, 2002 Pleiotropic model of maintenance of quantitative genetic variation at mutationselection balance. Genetics 161: 119-133.