Contribution of the Trypanosoma cruzi genome project to the understanding of chagas disease pathogenesis;Contribucion del proyecto genoma de Trypanosoma cruzi a la comprension de la patogenesis de la cardiomiopatia chagasica cronica

Medicina

Volumn 59, Issue SUPPL. 2, 1999, Pages 18-24

  Levin, Mariano J ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Anti cardiac receptor antibodies; Chagas disease; Heart biopsies; Inverse antigens; SIRE associated sites

Indexed keywords

ANIMAL; ANTIGEN ANTIBODY REACTION; ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; COMPUTER NETWORK; GENETIC MARKER; GENETICS; GENOME; IMMUNOLOGY; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; TRYPANOSOMA CRUZI;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; BASE SEQUENCE; CHAGAS CARDIOMYOPATHY; CHRONIC DISEASE; COMPUTER COMMUNICATION NETWORKS; GENETIC MARKERS; GENOME, PROTOZOAN; MOLECULAR SEQUENCE DATA; TRYPANOSOMA CRUZI;

EID: 0043206650     PISSN: 00257680     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Cohen D, Chumakov I, Weissenbach J. A first-generation physical map of the human genome. Nature 1993; 336: 698-701.
2. Levin MJ, Ferrari I, Vázquez M, et al. Toward the physical map of the Trypanosoma cruzi nuclear genome. Mem Inst Oswaldo Cruz 1994; 89-Suppl.: 17-8.
3. Brandáriz S, Ferrari I, Saumier M, et al. The Trypanosoma cruzi genome project: Genome Sequence Sampling (GSS) strategy for high resolution physical mapping. Mem Inst Oswaldo Cruz 1995; 90-Suppl.: 20-1.
4. Zingales B, Rondinelli E, Degrave W, et al. The Trypanosoma cruzi (jenome initiative. Parasitol. Today 1997; 13: 16-22.
5. Ferrari I, Lorenzi H, Santos MR, et al. Towards the physical map of the Trypanosoma cruzi nuclear genome: construction of YAC and BAC libraries of the reference clone T. cruzi CL-Brener. Mem Inst Oswaldo Cruz 1997; 92: 843-62.
6. Degrave W, Levin MJ, da Silveira JF. Parasite genome projects and the Trypanosoma cruzi initiative. Mem Inst Oswaldo Cruz 1997; 92: 859-62.
7. Degrave W, de Miranda AB, Amorim A, Brandão A, Aslett M, Vandeyar M. TcruziDB, an integrated Database, and the WWW information server for the Trypanosoma cruzi Genome Project. Mem Inst Oswaldo Cruz 1997; 92: 305-9.
8. Rosenbaurr MB, Chiale PA, Schejtman D, Levin MJ, Elizari MV. Antibodies to b-adrenergic receptors disclosing agonist-like properties in idiopathic dilated cardiomyopathy and Chagas heart disease. J Cardiovasc Electrophysiol 1994; 5: 367-75.
9. Chiale PA, Feigelson EA, Levin MJ, Elizari MV, Hoebeke J, Rosenbaum MB. Anticuerpos antirreceptores b-adrenérgicos en la enfermedad de Chagas crónica. Rev ArgCardiol 1994; 62: 31-8.
10. Ferrari I, Levin MJ, Wallukat G, et al. Molecular mimicry between the immunodominant ribosomal protein PO of T. cruzi and a functional epitope on the human beta 1-adrenergic receptor. J Exp Med 1995; 182: 59-65.
11. Chiale PA, Vallaza M, Feigelson E, et al. Anticuerpos antireceptores adrenérgicos beta con actividad agonista parcial en pacientes con cardiopatía eléctrica primaria. Rev Argent Cardiol 1996; 64: 119-27.
12. Elíes R, Ferrari I, Wallukat G, et al. Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease. J Immunol 1996; 157: 4203-11.
13. Kaplan D, Ferrari I, López Bergami P, et al. Antibodies to ribosomal P proteins of Trypanosoma cruzi in Chagas disease possess functional autoreactivity with heart tissue and differ from anti-P autoantibodies in Lupus. Proc Natl Acad Sci 1997; 94: 10301-6.
14. Ferrari I, Levin MJ, Elizari M, Rosenbaum M, Chiale P. Cholinergic autoantibodies in sinus node dysfunction. Lancet 1997; 350: 262-3.
15. Kaplan D, Ferrari I, López Bergami P, et al. Los anticuerpos antiproteínas ribosomales P estimulan el receptor b adrenérgico en la Enfermedad de Chagas pero no en el lupus eritematoso sistémico. Rev Argent Cardiol 1998; 66: 127-37.
16. Masuda M, Levin MJ, Farías de Oliveira S, et al. Functionaly active cardiac antibodies in Chronic Chagas Disease are specifically blocked by Trypanosoma cruzi antigens, FASEB J 1998; 12: 1551-8.
17. Ferrari I, Kaplan D, Mahler E, et al. Generation of antibodies with functional autoreactive properties in Chagas disease. Mem Inst Oswaldo Cruz 1998; Suppl. 93: 83-4.
18. Ghio S. Antígenos de Trypanosoma cruzi obtenidos por rastreo inmunológico. Tesis de licenciatura. Dpto. de ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1996.
19. Hanakahi LA, Dempsey LA, Li MJ, Maizels N. Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. Proc Natl Acad Sci 1997; 94: 3605-10.
20. Levin MJ, Mesri E, Benarous R, et al. Identification of major Trypanosoma cruzi antigenic determinants in chronic Chagas' heart disease. Am J Trop Med Hyg 1989; 41: 530-9.
21. Ghio S, Lorenzi H, Brandao A, et al. Inverse antigens: a solid link between the Trypanosoma cruzi genome project and Chagas' heart disease. Tenth International Genome Sequencing and Analysis Conference, Miami, FL, USA September 18-21, 1998.
22. López Bergami P, Cabeza Meckert P, Kaplan D, et al. Immunization with recombinant Trypanosoma cruzi ribosomal P protein induces changes in the electrocardiogram of immunized mice. FEMS Immunol Med Microbiol 1997; 18: 75-85.
23. Santos M, Lorenzi H, Do Carmo M, et al. Physical Map of a 650 kb chromosomal region encompassing the genes of two immunodominant repetitive antigens of Trypanosoma cruzi. 1999, (submitted for publication).
24. Azevedo V, Levitus G, Miyoshi A, Cândido AL, Goes AM, Oliveira SC. Main features of DNA-based immunization vectors. Braz J Med Biol Res 1999; 32: 147-53.
25. Weston D, Patel B, Van Voorhis W. Virulence in Trypanosoma cruzi infection correlates with the expression of a distinct family of sialidase superfamily genes. Mol Biochem Parasitol 1999; 98: 105-16.
26. Chiurrillo M, Cano I, da Silveira J, Ramírez JL. Organization of telomeric and subtelomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi. Mol Biochem Parasitol 1999; (in press).
27. Anderson B, Aslund L, Tammi M, et al. Complete sequence of a 93.4-kb contig from chromosome 3 of Trypanosoma cruzi containing a strand-switch region. Genome Res 1998; 8: 809-16.
28. Vázquez MP, Schijman AG, Levin MJ. A short interspersed repetitive element provides a new 3′ acceptor site for transsplicing in certain ribosomal P2b protein genes of Trypanosoma cruzi. Mol Biochem Parasitol 1994; 64: 327-36.
29. Cano MI, Gruber A, Vazquez M, et al. Molecular karyotype of Trypanosoma cruzi CL-Brener reference clone of the T. cruzi genome project. Mol Biochem Parasitol 1995; 71: 273-8.
30. Vázquez M, Lorenzi H, Schijman A, Ben-Dov C, Levin MJ. Analysis of the distribution of SIRE in the nuclear genome of Trypanosoma cruzi reveals its linkage to other repetitive sequences and protein coding genes. Gene 1999, (submitted for publication).
31. Brandariz S, Schijman A, Vigliano C, Viotti R, Levin MJ. Role of parasites in the pathogenesis of Chagas cardiomyopathy. Lancet 1996; 347: 913-4.
32. Berek C, Kim HJ. B-cell activation and development within chronically inflammed synovium in rheumatoid and reactive arthritis. Seminars in Immunology 1997; 9: 261-8.
33. Macina R. Diversidad de secuencia de los minicírculos de T. cruzi. Tesis doctoral, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1990.