Cytotoxicity of stimulated equine neutrophils on equine endothelial cells in culture

Equine Veterinary Journal

Volumn 32, Issue 4, 2000, Pages 327-333

  Benbarek, H ^a   Grulke S ^a   Deby Dupont, G ^a,b   Deby, C ^a   Mathy Hartert, M ^a   Caudron, I ^a   Dessy Doize, C ^a   Lamy, M ^a,b   Serteyn, D ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Endothelium; Horse; Myeloperoxidase; Neutrophils; Oxidant stress; Reactive oxygen species

Indexed keywords

HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CELL CULTURE; CYTOTOXICITY; ENDOTHELIUM; HORSE; HORSE DISEASE; IMMUNOLOGY; INFLAMMATION; METABOLISM; NEUTROPHIL;

ANIMALS; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; ENDOTHELIUM; HORSE DISEASES; HORSES; HYDROGEN PEROXIDE; INFLAMMATION; NEUTROPHILS; REACTIVE OXYGEN SPECIES; SUPEROXIDES;

EID: 0043187463     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.2746/042516400777032273     Document Type: Article

References (37)

1. Babior, B.M. (1992) The respiratory burst oxidase. Adv. Enzymol. 65, 49-95.
2. Beilke, M.A. (1989) Vascular endothelium in immunology and infectious disease. Rev. Infect. Dis. 11, 273-283.
3. Carreras, M.C., Pargament, G.A., Catz, S.D., Podoroso, J.J. and Boveris, A. (1994) Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils. FEBS Lett. 341, 65-68.
4. Deby, C. and Goutier, R. (1990) New perspectives on the biochemistry of superoxide anion and the effiency of superoxide dismutases. Biochem. Pharmacol. 39, 399-405.
5. Deby-Dupont, G., Caudron, I., Mathy-Hartert, M., Benbarek, H., Grülke, S., Deby, C., Lamy, M. and Serteyn, D. (1998) Equine neutrophil myeloperoxidase in plasma: design of a radioimmunoassay and first results in septic pathologies. Vet. Immun. Immunopathol. 66, 257-271.
6. Eiserich, J.P., Hristova, M., Cross, C.B., Jones, D.A., Freeman, B.A. Halliwell, B. and Van der Vliet, A. (1998) Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils. Nature 301, 393-397.
7. Freeman, B.A. and Crapo, J.D. (1982) Biology of disease: free radicals and tissue injury. Lab. Invest. 47, 412-426.
8. Grülke, S., Benbarek, H., Caudron, I., Deby-Dupont, G., Mathy-Hartert, M., Farnir, F., Deby, C., Lamy, M. and Serteyn, D. (1999) Plasma myeloperoxidase level and polymorphonuclear leucocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results. Can. J. vet. Res. 63, 142-147.
9. Hurst, K., Albrieh, J.M., Green, T.R., Rosen, H. and Klebanoff, S.J. (1984) Myeloperoxidase-dependent fluorescein clorination by stimulated neutrophils. J. Biol. Chem. 259, 4812-4821.
10. Jaffe, E.A. (1987) Cell biology of endothelial cells. Hum. Pathol. 18, 234-239.
11. Jaffe, E.A., Nachman, R.I., Becker, C.G. and Monick, C.R. (1975) Culture of human endothelial cells derived from human umbilical veins. J clin. Invest. 52, 2747-2753.
12. Janoff, A. (1975) At least three human neutrophil lysosomal proteases are capable of degrading joint connective tissues. Ann. N. Y. Acad. Sci. 256, 402-408.
13. Karlsson, K.A. and Marklund, S.L. (1988) Extracellular superoxide dismutase in the vascular system of mammals. Biochem. J. 255, 223-228.
14. Kvietys, P.R., Inauen, W., Bacon, B.R. and Grisham, M.B. (1989) Xanthine-oxidase-induced injury to endothelium: role of intracellular iron and hydroxyl radical. Am. J. Physiol. 257, H1640-H1646.
15. MacEachern, K.E., Smith, G.L. and Nolan, A.M. (1997) Methods for the isolation, culture and characterization of equine pulmonary artery endothelial cells. Res. vet. Sci. 62, 147-152.
16. Mantovani, A., Bussolino, F. and Dejan, H. (1992) Cytokine regulation of endothelial cell function. FASEB J. 6, 2591-2599.
17. Mathy-Hartert, M., Bourgeois, F., Grülke, S., Deby-Dupont, G., Caudron, I., Deby, C., Lamy, M. and Serteyn, D. (1998) Purification of myeloperoxidase from equine polymorphonuclear leucocytes. Can. J. vet. Res. 62, 127-132.
18. Mathy-Hartert, M., Deby-Dupont, G., Deby, C., Jadoul, L., Vandenberghe, A. and Lamy, M. (1995) Cytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime. Mediat. Inflamm. 4, 437-443.
19. Moore, R.M., Bertone, A.L., Bailey, M.Q., Muir, W.W. and Beard, W.L. (1994) Neutrophil accumulation in the large colon of horses during low-flow ischemia and reperfusion. .Am. J. vet. Res. 55, 1454-1463.
20. Nakagima, K., Powers, J.C., Ashe, B.M. and Zimmerman, M. (1979) Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. J. Biol. Chem. 254, 4027-4032.
21. Nourshargh, S. and Williams, T.J. (1990) Neutrophils and neutrophil-endothelial cell interactions in vivo. In: The Endothelium: An Introduction to Current Research, Ed: J.B. Warren, Wiley-Liss, New York, pp 171-186.
22. Osborn, L. (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62, 3-6.
23. Pober, J.S. and Cotran, R.S. (1990) The role of endothelium in inflammation. Transplantation 50, 537-544.
24. Pycock, J.K., Allen, W.E. and Morris, T.H. (1987) Rapid, single-step isolation of equine neutrophils on a discontinuous Percoll density gradient. Res. vet. Sci. 42, 411-412.
25. Ramos, C.L., Pou, S.P., Britigan, B.H., Cohen, M.S. and Rosen, G.M. (1992) Spin trapping evidence for myeloperoxidase dependent hydroxyl radical formation by human neutrophils and monocytes. J. Biol. Chem. 267, 8307-8312.
26. Rinaldo, J.E. and Gorry, M. (1990) Protection by deferoxamine from endothelial injury: a possible link with inhibition of intracellular xanthine oxidase. Am. J. respir. Cell. mol. Biol. 3, 525-533.
27. Rossi, F., Romeo, D. and Patriarca, P.J. (1972) Mechanism of phagocytosis-associated oxidative metabolism in polymorphonuclear leucocytes and macrophages. Reticuloendoth. Soc. 12, 127-149.
28. Sampson, J.B., Ye. Y., Rosen, H. and Beckmann, J.S. (1998) Myeloperoxidase and horseradish peroxidase catalyze tyrosin nitration in proteins from nitrite and hydrogen peroxide. Arch. Bioehem. Biophys. 356, 207-213.
29. Shi, X., Lenhart, A. and Mao, Y. (1994) ESR spin trapping investigation on peroxynitrite decomposition: no evidence for hydroxyl radical production. Biochem. Biophys. Res. Commun. 203, 1515-1521.
30. Shireman, P.K. and Pearce, W.H. (1996) Endothelial cell function: biologic and physiologic functions in health and disease. Am. J. Roentgenoi. 166, 7-13.
31. Tonnesen, M.G., Smedly, L.A. and Henson, P.M. (1984) Neutrophil-endothelial cell interactions. Modulation of neutrophil adhesiveness induced by complement fragments C5a and C5a des arg and formyl-methionyl-leucyl-phenylalanine in vitro. J. clin. Invest. 74, 1581-1592.
32. Turek, J.J., Templeton, C.B., Bottoms, G.D. and Fessier, J.F. (1985) Flunixin meglumine attenuation of endotoxin-induced damage to the cardiopulmonary vascular endothelium of the pony. Am. J. vet. Res. 46, 591-596.
33. Vane, J.R., Anggard, E.E. and Botting, R.M. (1990) Regulatory functions of the vascular endothelium. New Engl. J. Med. 323, 27-36.
34. Vercellotti, G.M., Moldow, C.F. Wickham, N.W.R. and Jacob, H.S. (1990) Endothelial cell platelet-activating factor primes neutrophil responses: amplification of endothelial activation by neutrophil products. J. lipid Med. 2, S23-S30.
35. Weiss, S.J. (1989) Tissue destruction by neutrophils. New Engl. J. Med. 320, 365-376.
36. Williams, T.J. and Hellewell, P.G. (1992) Endothelial cell biology. Adhesion molecules involved in the microvascular inflammatory response. Am. Rev. Respir. Dis. 146, S45-S50.
37. Zimmerman, G.A., Prescott, S.M. and McIntyre, T.M. (1992) Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol. Today 13, 93-99.