Liquid-liquid immiscibility in membranes

Annual Review of Biophysics and Biomolecular Structure

Volumn 32, Issue , 2003, Pages 469-492

  McConnell, Harden M ^a   Vrljic, Marija ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

Cell membranes; Cholesterol phospholipid mixtures; Condensed complexes; Lipid rafts; Phase diagrams

Indexed keywords

CHOLESTEROL; PHOSPHOLIPID;

COMPLEX FORMATION; CONCENTRATION (PARAMETERS); HUMAN; LIPID BILAYER; LIPID COMPOSITION; LIPID MONOLAYER; MEMBRANE COMPONENT; MEMBRANE PERMEABILITY; MISCIBILITY; MOLECULAR MODEL; NONHUMAN; PHASE SEPARATION; PRIORITY JOURNAL; REVIEW; TEMPERATURE; THERMODYNAMICS;

ANIMALS; CELL MEMBRANE; CHOLESTEROL; COLLOIDS; LIPID BILAYERS; MACROMOLECULAR SUBSTANCES; MEMBRANE FLUIDITY; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MEMBRANES, ARTIFICIAL; PHOSPHOLIPIDS; SOLUTIONS;

ANIMALIA;

EID: 0043180430     PISSN: 10568700     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biophys.32.110601.141704     Document Type: Review

References (87)

1. Almeida PFF, Vaz WLC, Thompson TE. 1992. Lateral diffusion in the liquid-phases of dimyrostoylphosphatidylcholine cholesterol lipid bilayers: a free volume analysis. Biochemistry 31:6739-47
2. Anderson RGW. 1998. The caveolae membrane system. Annu. Rev. Biochem. 67:199-225
3. Anderson RGW, Jacobson K. 2002. Cell biology: a role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296:1821-25
4. Anderson TG, McConnell HM. 2001. Condensed complexes and the calorimetry of cholesterol-phospholipid bilayers. Biophys. J. 81:2774-85
5. Anderson TG, McConnell HM. 2002. A thermodynamic model for extended complexes of cholesterol and phospholipid. Biophys. J. 83:2039-52
6. Benvegnu DJ, McConnell HM. 1993. Surface dipole densities in lipid monolayers. J. Phys. Chem. 97:6686-91
7. Bromley SK, Burack WR, Johnson KG, Somersalo K, Sims TN, et al. 2001. The immunological synapse. Annu. Rev. Immunol. 19:375-96
8. Brown DA, London E. 1998. Functions of lipid rafts in biological membranes. Annu. Rev. Cell Dev. Biol. 14:111-36
9. Brown DA, London E. 1998. Structure and origin of lipid domains in biological membranes. J. Membr. Biol. 164:103-14
10. Brown DA, London E. 2000. Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J. Biol. Chem. 275:17221-24
11. Corrales LR, Wheeler JC. 1989. Chemical reaction driven phase transitions and critical points. J. Chem. Phys. 91:7097-112
12. Dervichian DG. 1958. Surface Science in Chemistry and Biology, p. 70. Oxford: Pergamon
13. Dietrich C, Bagatolli LA, Volovyk ZN, Thompson NL, Levi M, et al. 2001. Lipid rafts reconstituted in model membranes. Biophys. J. 80:1417-28
14. Dietrich C, Volovyk ZN, Levi M, Thompson NL, Jacobson K. 2001. Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers. Proc. Natl. Acad. Sci. USA 98:10642-47
15. Feingold L. 1993. Cholesterol in Membrane Models. Ann Arbor, MI: CRC
16. Field KA, Holowka D, Baird B. 1995. FcεRI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular-signaling. Proc. Natl. Acad. Sci. USA 92:9201-5
17. Field KA, Holowka D, Baird B. 1997. Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains. J. Biol. Chem. 272:4276-80
18. Finean JB. 1953. Phospholipid-cholesterol complex in the structure of myelin. Experientia 9:17-19
19. Fraser DP, Zuckermann MJ, Mouritsen OG. 1991. Theory and simulations for hard-disk models of binary mixtures of molecules with internal degrees of freedom. Phys. Rev. A 43:6642-56
20. Gershfeld NL. 1978. Equilibrium studies of lecithin-cholesterol interactions. I. Biophys. J. 22:469-88
21. Hagen JP. 1996. The physical chemistry of lipid monolayers at the air-water interface. PhD thesis. Stanford Univ.
22. Hagen JP, McConnell HM. 1997. Liquid-liquid immiscibility in lipid monolayers. Biochim. Biophys. Acta 1329:7-11
23. Hao M, Mukherjee S, Maxfield FR. 2001. Cholesterol depletion induces large scale domain segregation in living cell membranes. Proc. Natl. Acad. Sci. USA 98:13072-77
24. Harder T, Kuhn M. 2000. Selective accumulation of raft-associated membrane protein LAT in T-cell receptor signaling assemblies. J. Cell Biol. 151:199-207
25. Harder T, Scheiffele P, Verkade P, Simons K. 1998. Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol. 141:929-42
26. Harder T, Simons K. 1999. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: accumulation of actin regulated by local tyrosine phosphorylation. Eur. J. Immunol. 29:556-62
27. Hinz H, Sturtevant JM. 1972. Calorimetric investigation of the influence of cholesterol on the transition properties of bilayers formed from synthetic L-α-lecithins in aqueous suspension. J. Biol. Chem. 247:3697-700
28. Holowka D, Sheets ED, Baird B. 2000. Interactions between FcεRI and lipid raft components are regulated by the actin cytoskeleton. J. Cell Sci. 113:1009-19
29. Huang J, Feigensen GW. 1999. A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers. Biophys. J. 76:2142-57
30. Ipsen JH, Karlstrom G, Mouritsen OG, Wennerstrom H, Zuckermann MJ. 1987. Phase equilibria in the phosphatidylcholine-cholesterol system. Biochim. Biophys. Acta 905:162-72
31. Jacobson K, Dietrich C. 1999. Looking at lipid rafts? Trends Cell Biol. 9:87-91
32. Janes PW, Ley SC, Magee AI. 1999. Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor. J. Cell Biol. 147:447-61
33. Jost PC, Griffith OH. 1978. Lipid-protein interactions: influence of integral membrane proteins on bilayer lipids. In Biomolecular Structure and Function, ed. PF Agris, pp. 25-65. New York: Academic
34. Keller SL, Pitcher WH III, Huestis WH, McConnell HM. 1998. Red blood cell lipids form immiscible lipids. Phys. Rev. Lett. 81:5019-22
35. Keller SL, Radhakrishnan A, McConnell HM. 2000. Saturated phospholipids with high melting temperature for complexes with cholesterol in monolayers. J. Phys. Chem. B 104:7522-27
36. Kinet J. 1999. The high-affinity IgE receptor (FcεRI): from physiology to pathology. Annu. Rev. Immunol. 17:931-72
37. Krummel MF, Davis MM. 2002. Dynamics of the immunological synapse: finding, establishing and solidifying a connection. Curr. Opin. Immunol. 14:66-74
38. Langlet C, Bernard A, Drevot P, He H. 2000. Membrane rafts and signaling by the multichain immune recognition receptors. Curr. Opin. Immunol. 12:250-55
39. Leathes JB. 1925. Condensing effect of cholesterol on monolayers. Lancet 208:853-56
40. Lee K, Holdorf AD, Dustin ML, Chan AC, Allen PM, Shaw AS. 2002. T cell receptor signaling precedes immunological synapse formation. Science 295:1539-42
41. Marsh D, Watts A. 1982. Spin labeling and lipid-protein interactions in membranes. In Lipid-Protein Interactions ed. PC Jost, OH Griffith, 2:53-126. New York: Wiley
42. McConnell HM. 1991. Structures and transitions in lipid monolayers at the air-water interface. Annu. Rev. Phys. Chem. 42:171-95
43. McConnell HM, Radhakrishnan A. 2003. Condensed complexes of cholesterol and phospholipids. Biochim. Biophys. Acta Biomembr. In press
44. McMullen TPW, Ruthven NAH, Lewis RN, McElhaney RN. 1999. Calorimetric and spectroscopic studies of the effects of cholesterol on the thermotrophic phase behavior and organization of a homologous series of linear saturated phosphatidylethanolamine bilayers. Biochim. Biophys. Acta 1416:119-34
45. Miao L, Nielsen M, Thewalt J, Ipsen JH, Bloom M, et al. 2002. From lanosterol to cholesterol: structural evolution and differential effects on lipid bilayers. Biophys. J. 82:1429-44
46. Monk CRF, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. 1998. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 395:82-86
47. Montixi C, Langlet C, Bernard A, Thimonier J, Dubois C, et al. 1998. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains. EMBO J. 17:5334-38
48. Needham D, McIntosh TJ, Evans E. 1988. Thermomechanical and transition properties of dimyristoylphosphatidylcholine cholesterol bilayers. Biochemistry 27:4468-73
49. Okonogi TM, Radhakrishnan A, McConnell HM. 2002. Two fatty acids can replace one phospholipid in condensed complexes with cholesterol. Biochim. Biophys. Acta 1564:1-4
50. Phillips MC. 1972. The physical state of phospholipids and cholesterol in monolayers, bilayers, and membranes. Prog. Surf. Membr. Sci. 5:139-221
51. Pierini L, Harris NT, Holowka D, Baird B. 1997. Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE-FcεRI aggregates and downstream signaling pathways. Biochemistry 36:7447-56
52. Pralle A, Keller P, Florin EL, Simons K, Horber JKH. 2000. Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J. Cell Biol. 148:997-1007
53. Prior IA, Harding A, Yan J, Slumier J, Parton RG, Hancock JF. 2001. GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat. Cell Biol. 3:368-75
54. Pyenta PS, Holowka D, Baird B. 2001. Cross-correlation analysis of inner-leaflet-anchored green fluorescent protein co-redistributed with IgE receptors and outer leaflet lipid raft components. Biophys. J. 80:2120-32
55. Radhakrishnan A, Anderson TG, McConnell HM. 2000. Condensed complexes, rafts, and the chemical activity of cholesterol in membranes. Proc. Natl. Acad. Sci. USA 97:12422-27
56. Radhakrishnan A, Li X-M, Brown RE, McConnell HM. 2001. Stoichiometry of cholesterol-sphingomyelin condensed complexes in monolayers. Biochim. Biophys. Acta 1511:1-6
57. Radhakrishnan A, McConnell HM. 1999. Cholesterol-phospholipid complexes in membranes. J. Am. Chem. Soc. 121:486-87
58. Radhakrishnan A, McConnell HM. 1999. Condensed complexes of cholesterol and phospholipids. Biophys. J. 77:1507-17
59. Radhakrishnan A, McConnell HM. 1999. Electric field effect on cholesterol-phospholipid complexes. Proc. Natl. Acad. Sci. USA 97:1073-78
60. Radhakrishnan A, McConnell HM. 2000. Chemical activity of cholesterol in membranes. Biochemistry 39:8119-24
61. Radhakrishnan A, McConnell HM. 2002. Critical points in charged membranes containing cholesterol. Proc. Natl. Acad. Sci. USA 99:13391-96
62. Radhakrishnan A, McConnell HM. 2002. Thermal dissociation of condensed complexes of cholesterol and phospholipid. J. Phys. Chem. 106:4755-62
63. Rechtenwald DJ, McConnell HM. 1981. Phase equilibria in binary mixtures of phosphatidylcholines and cholesterol. 20:4505-10
64. Rowlinson JS, Swinton FL. 1982. Liquids and Liquid Mixtures. London/Boston: Butterworth Sci.
65. Rubenstein JL, Owicki JC, McConnell HM. 1980. Dynamic properties of phosphatidylcholines and cholesterol. Biochemistry 19:569-73
66. Samsonov AV, Mihalyov I, Cohen FS. 2001. Characterization of cholesterol-sphingomyelin domains and their dynamics in bilayer membranes. Biophys. J. 81:1486-500
67. Schütz GJ, Schindler H, Schmidt T. 1997. Single-molecule microscopy on model membranes reveals anomalous diffusion. Biophys. J. 73:1073-80
68. Sheets ED, Holowka D, Baird B. 1999. Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcεRI and their association with detergent-resistant membranes. J. Cell Biol. 145:877-87
69. Sheets ED, Lee GM, Simson R, Jacobson K. 1997. Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane. Biochemistry 36:12449-58
70. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-72
71. Simons K, Toomre D. 2000. Lipid rafts and signal transduction. Nat. Mol. Cell Biol. 1:31-39
72. Simons K, van Meer G. 1988. Lipid sorting in epithelial cells. Biochemistry 27:6197-202
73. Somerharju P, Virtanen JA, Cheng KH. 1999. Lateral organization of membrane lipids. The superlattice view. Biochim. Biophys. Acta 1440:32-48
74. Sprong H, van der Sluijs P, van Meer G. 2001. How proteins move lipids and lipids move proteins. Nat. Rev. Mol. Cell Biol. 21:504-13
75. Stauffer TP, Meyer T. 1997. Compartmentalized IgE receptor-mediated signal transduction in living cells. J. Cell Biol. 139:1447-54
76. Subramaniam S, McConnell HM. 1987. Critical mixing in monolayer mixtures of phospholipid and cholesterol. J. Phys. Chem. 91:1715-18
77. Sugar IP, Tang D, Chong PL. 1994. Monte Carlo simulation of lateral distribution of molecules in a two-component lipid membrane. Effect of long-range repulsive interactions. J. Phys. Chem. 98:7201-10
78. Suzuki K, Sheetz MP. 2001. Binding of cross-linked glycosylphosphatidylinositol-anchored proteins to discrete actin-associated and cholesterol-dependent domains. Biophys. J. 81:2181-89
79. Thomas JL, Holowka D, Baird B, Webb WW. 1994. Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins. J. Cell Biol. 125:795-802
80. Varma R, Mayor S. 1998. GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394:798-801
81. Veatch SL, Keller SL. 2002. Organization in lipid membranes containing-cholesterol. Phys. Rev. Lett. 89:268101
82. Vidalain PO, Azocar O, Servet-Delprat C, Rabourdin-Combe C, Gerlier D, Manie S. 2000. CD40 signaling in human dendritic cells is initiated within membrane rafts. EMBO J. 19:3304-13
83. Villaba M, Bi K, Rodrigez F, Tanaka Y, Schoenberger S, Altman A. 2001. Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. J. Cell Biol. 155:331-38
84. Virtanen JA, Ruonala M, Vauhkonen M, Somerharju P. 1995. Lateral organization of liquid-crystalline cholesterol-dimyristoylphosphatidylcholine bilayers. Evidence for domains with hexagonal and centered rectangular cholesterol superlattices. Biochemistry 34:11568-81
85. Vist MR, Davis JH. 1989. Phase equilibria of cholesterol/dipalmitoylphosphatidylcholine mixtures: D nuclear magnetic resonance and differential scanning calorimetry. Biochemistry 29:451-64
86. Wang MM, Sugar IP, Chong PL. 1998. Role of the sterol superlattice in the partitioning of the antifungal drug nystatin into lipid membranes. Biochemistry 37:11797-805
87. Xavier R, Brennan T, Li QQ, McCormack C, Seed B. 1998. Membrane compartmentation is required for efficient T-cell activation. Immunity 8:723-32