Kinetics of haematopoietic recovery after dose-intensive chemo/ radiotherapy in mice: Optimized erythroid support with darbepoetin alpha

British Journal of Haematology

Volumn 122, Issue 4, 2003, Pages 623-636

  Hartley, Cynthia ^a   Elliott, Steve ^a   Begley, C Glenn ^a   McElroy, Patricia ^a   Sutherland, Weston ^a   Khaja, Raheem ^a   Heatherington, Anne C ^a   Graves, Tom ^a   Schultz, Henry ^a   Del Castillo, Juan ^a   Molineux, Graham ^a  

^a AMGEN INC   (United States)

Author keywords

Darbepoetin alpha; Erythropoiesis; Multicycle chemo radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; ERYTHROPOIETIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; ANIMAL MODEL; ARTICLE; BLOOD TRANSFUSION; BONE MARROW DISEASE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; COLONY FORMING UNIT; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE EXACERBATION; DOSE RESPONSE; DRUG CLEARANCE; DRUG HALF LIFE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROID CELL; FEMALE; HEMATOPOIESIS; HEMOGLOBIN DETERMINATION; KIDNEY INJURY; LIVER INJURY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE;

ANEMIA; ANIMALS; ANTINEOPLASTIC AGENTS; CARBOPLATIN; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ERYTHROPOIETIN; ERYTHROPOIETIN, RECOMBINANT; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HEMOGLOBINS; MICE; MICE, INBRED STRAINS; RADIATION INJURIES; RADIOTHERAPY;

EID: 0043163748     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04467.x     Document Type: Article

References (32)

1. Basser, R.L., Rasko, J., Clarke, K., Cebon, J., Green, M.D., Grigg, A.P., Zalcberg, J., Cohen, B., O'Byrne, J., Menchaca, D.M., Fox, R.M. & Begley, C.G. (1997) Randomized, blinded, placebo-controlled phase I trial of pegylated recombinant human megakaryocyte growth and development factor with filgrastim after dose-intensive chemotherapy in patients with advanced cancer. Blood, 89, 3118-3128.
2. Canaday, D.J., Regine, W.F. & Mohiuddin, M. (1999) Significance of pretreatment hemoglobin level in patients with T1 glottic cancer. Radiation Oncology Investigations, 7, 42-48.
3. Cazzola, M., Guarnone, R., Cerani, P., Centenara, E., Rovati, A. & Beguin, Y. (1998) Red blood cell precursor mass as an independent determinant of serum erythropoietin level. Blood, 91, 2139-2145.
4. Crawford, J., Ozer, H., Stoller, R., Johnson, D., Lyman, G., Tabbara, I., Kris, M., Grous, J., Picozzi, V., Rausch, G., Smith, R., Gradishar, W., Yahanda, A., Vincent, M., Stewart, M. & Glaspy, J. (1991) Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. New England Journal of Medicine, 325, 164-170.
5. Demetri, G.D. (2001) Anaemia and its functional consequences in cancer patients: current challenges in management and prospects for improving therapy. British Journal of Cancer, 84, 31-37.
6. Dusenbery, K.E., McGuire, W.A., Holt, P.J., Carson, L.F., Fowler, J.M., Twiggs, L.B. & Potish, R.A. (1994) Erythropoietin increases hemoglobin during radiation therapy for cervical cancer. International Journal of Radiation, Oncology, Biology and Physics, 29, 1079-1084.
7. Egrie, J.C. & Browne, J.K. (2001) Development and characterization of novel erythropoiesis stimulating protein (NESP). British Journal of Cancer, 84, 3-10.
8. Egrie, J.C., Dwyer, E., Browne, J.K., Hitz, A. & Lykos, M.A. (2003) Darbepoetin alfa has a longer serum half-life and greater in vivo potency than recombinant human erythropoietin. Experimental Hematology, 31, 290-299.
9. Elliott, S., Lorenzini, T., Asher, S., Aoki, K., Brankow, D., Buck, L., Busse, L., Chang, D., Fuller, J., Grant, J., Hernday, N., Hokum, M., Hu, S., Knudten, A., Levin, N., Komorowski, R., Martin, F., Navarro, R., Osslund, T., Rogers, G., Rogers, N., Trail, G. & Egrie, J. (2003) Enhancement of therapeutic protein in vivo activities through glycoengineering. Nature Biotechnology, 21, 414-421.
10. Gabrilove, J.L., Cleeland, C.S., Livingston, R.B., Sarokhan, B., Winer, E. & Einhorn, L.H. (2001) Clinical evaluation of once-weekly dosing of epoetin alfa in chemotherapy patients: improvements in hemoglobin and quality of life are similar to three-times-weekly dosing. Journal of Clinical Oncology, 19, 2875-2882.
11. Glaspy, J., Jadeja, J.S., Justice, G., Kessler, J., Richards, D., Schwartzberg, L., Rigas, J., Kuter, D., Harmon, D., Prow, D., Demetri, G., Gordon, D., Arseneau, J., Saven, A., Hynes, H., Boccia, R., O'Byrne, J. & Colowick, A.B. (2001) A dose-finding and safety study of novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia in patients receiving multicycle chemotherapy. British Journal of Cancer, 84, 17-23.
12. Grogan, M., Thomas, G.M., Melamed, I., Wong, F.L., Pearcey, R.G., Joseph, P.K., Portelance, L., Crook, J. & Jones, K.D. (1999) The importance of hemoglobin levels during radiotherapy for carcinoma of the cervix. Cancer, 86, 1528-1536.
13. Heil, G. & Barge, A.J. (1998) Use of filgrastim (r-metHuGCSF) in acute myeloid leukemia. In: Filgrastim (r-metHuG-CSF) in Clinical Practice 2nd edn. (ed. by G. Morstyn, T.M. Dexter & M.A. Foote), pp. 511-531. Marcel Dekker, New York.
14. Hokom, M., Lacey, D., Kinstler, O., Choi, E., Kaufman, S., Faust, J. Rowan, C., Dwyer, E., Nichol, J.L., Grasel, T., Wilson, J., Steinbrink, R., Hecht, R., Winters, D., Boone, T. & Hunt, P. (1995) Pegylated megakaryocyte growth and development factor abrogates the lethal thrombocytopenia associated with carboplatin and irradiation in mice. Blood, 86, 4486-4492.
15. Holmes, D.D. (1998) Normal ranges. In: Clinical Laboratory Animal Medicine 2nd edn. (ed. by K. Hrapkiewicz, L. Medina, & D.D. Holmes), p. 259. Iowa State University Press, Ames: IA.
16. Lee, W.R., Berkey, B., Marcial, V., Fu, K.K., Cooper, J.S., Vikram, B., Coia, L.R., Rotman, M. & Ortiz, H. (1998) Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27. International Journal of Radiation, Oncology, Biology and Physics, 42, 1069-1075.
17. Leonard, J., Quinto, C., Kozitza, M., Neben, T. & Goldman, S. (1994) Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood, 83, 1499-1506.
18. MacDougall, I.C. (2000) Novel erythropoiesis stimulating protein. Seminars in Nephrology, 20, 375-381.
19. Mercadante, S., Gebbia, V., Marrazzo, A. & Filosto, S. (2000) Anaemia in cancer: pathophysiology and treatment. Cancer Treatment Reviews, 26, 303-311.
20. Nissenson, A.R., Swan, S.K., Lindberg, J.S., Soroka, S.D., Beatey, R., Wang, C., Picarello, N., McDermott-Vitak, A. & Maroni, B.J. (2002) Randomized, controlled trial of darbepoetin alfa for the treatment of anemia in hemodialysis patients. American Journal of Kidney Disease, 40, 110-118.
21. Obermair, A., Petru, E., Windbichler, G., Peters-Engl, C., Graf, A.H., Stummvoll, W., Kaider, A., Kurschel, S., Kolbl, H. & Sevelda, P. (2000) Significance of pretreatment serum hemoglobin and survival in epithelial ovarian cancer. Oncology Reports, 7, 639-644.
22. Pangalis, G.A., Siakantaris, M.P., Angelopoulou, M.K., Vassilakopoulos, T.P., Dimopoulou, M.N., Kyrtsonis, M.-C., Konstantopoulos, K., Tsaftaridis, P., Vaiopoulos, G.A. & Kontopidou, F.N. (2002) Downstaging Rai stage III B-chronic lymphocytic leukemia patients with the administration of recombinant human erythropoietin. Haematologica, 87, 500-506.
23. Phan, T., Crane, C., Mendoza, T., Vadhan, S., Brown, T., Hoff, P., Wolff, R.A., Abbruzzese, J., Curley, S., Feig, B., Ellis, L., Skibber, J., Wong, A., Cleeland, C. & Janjan, N. (2001) Low hemoglobin levels after preoperative chemotherapy for locally advanced rectal cancer are associated with a worse survival. Proceedings of the American Society for Clinical Oncology, 20, 151a.
24. Spivak, J.L. (1994) Cancer-related anemia: its causes and characteristics. Seminars in Oncology, 21, 3-8.
25. Takatsuki, F., Miyasaka, Y., Kikuchi, T., Suzuki, M. & Hamuro, J. (1996) Improvement of erythroid toxicity by lentinan and erythropoietin in mice treated with chemotherapeutic agents. Experimental Hematology, 24, 416-422.
26. Tarnawski, R., Skladowski, K. & Maciejewski, B. (1997) Prognostic value of hemoglobin concentration in radiotherapy for cancer of supraglottic larynx. International Journal of Radiation, Oncology, Biology and Physics, 38, 1007-1011.
27. Tejero, C., Lord, B.I., Mason, T.M. & Hendry, J.H. (1988) Long-term haemopoietic injury in mice after repeated irradiation: precursor-cell cycling and its regulation. European Journal of Haematology, 41, 278-284.
28. Thews, O., Kelleher, D.K. & Vaupel, P. (2001) Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors. Cancer Research, 61, 1358-1361.
29. Vanrenterghem, Y., Barany, P., Mann, J.F.E., Kerr, P.G., Wilson, J., Baker, N.F. & Gray, S.J. (2002) Randomized trial of darbepoetin alfa for treatment of renal anemia at a reduced dose frequency compared with rHuEPO in dialysis patients. Kidney International, 62, 2167-2175.
30. Warde, P., O'Sullivan, B., Bristow, R.G., Panzarella, T., Keane, T.J., Gullane, P.J., Witterick, I.P., Payne, D., Liu, F.F., Mclean, M., Waldron, J. & Cummings, B.J. (1998) T1/T2 glottic cancer managed by external beam radiotherapy: the influence of pretreatment hemoglobin on local control. International Journal of Radiation, Oncology, Biology and Physics, 41, 347-353.
31. Widness, J.A., Veng-Pedersen, P., Peters, C., Pereira, L.M., Schmidt, R.L. & Lowe, L.S. (1996) Erythropoietin pharmacokinetics in premature infants: developmental, nonlinearity, and treatment effects. Journal of Applied Physiology, 80, 140-148.
32. Wood, P.A. & Hrushesky, W.J.M. (1995) Cisplatin-associated anemia: an erythropoietin deficiency syndrome. Journal of Clinical Investigation, 95, 1650-1659.