The glutathione-mediated detoxification pathway in yeast: An analysis using the red pigment that accumulates in certain adenine biosynthetic mutants of yeasts reveals the involvement of novel genes

Archives of Microbiology

Volumn 180, Issue 2, 2003, Pages 108-117

  Sharma, Kailash Gulshan ^a,b   Kaur, Rupinder ^a,c   Bachhawat, Anand K ^a  

^a INSTITUTE OF MICROBIAL TECHNOLOGY   (India)

^b UNIVERSITY OF IOWA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adenine; Detoxification; Glutathione; Glutathione conjugate; Pump; Vacuole

Indexed keywords

ADENINE; BILE ACID TRANSPORTER; BILE PIGMENT TRANSPORTER; CARRIER PROTEIN; CASEIN KINASE; FUNGAL PROTEIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PIGMENT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; YEAST CADMIUM FACTOR;

ARTICLE; BIOACCUMULATION; BIOSYNTHESIS; CELL VACUOLE; CONJUGATION; CONTROLLED STUDY; CULTURE MEDIUM; DETOXIFICATION; ENZYME ACTIVITY; FUNGAL GENETICS; GENE ACTIVATION; GENE ACTIVITY; GENE FUNCTION; GENETIC ANALYSIS; GENETIC CODE; GENETIC SCREENING; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; YEAST;

ADENINE; CASEIN KINASE I; CASEIN KINASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, FUNGAL; GLUTATHIONE; GLUTATHIONE TRANSFERASE; PIGMENTS, BIOLOGICAL; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0043160475     PISSN: 03028933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00203-003-0566-z     Document Type: Article

References (31)

1. Anderson, ME (1985) Determination of glutathione and glutathione disulphide in biological samples. Methods Enzymol 113:548-555
2. Bourbouloux A, Shahi,P, Chakladar A, Delrot S, Bachhawat, AK (2000) Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae. J Biol Chem 275:13259-13265
3. Brown JL, North S, and Bussey H. (1993) SKN7, a yeast multi-copy suppressor of a mutation affecting cell wall β-glucan assembly, encodes a product with domains homologuous to prokaryotic two-component regullators and to heat shock transcription factors. J.Bacteriol 175:6908-15
4. Chaudhuri B, Ingavale S, Bachhawat, AK (1997) apd1 ±, a gene required for red pigment formation in the ade6 mutants of Schizosaccharomyces pombe encodes an enzyme required for glutathione biosynthesis : a role for glutathione and a glutathione-conjugate pump. Genetics 145:75-83
5. Choi JH, Lou W, Vancura A (1998) A novel membrane bound glutathione S-transferase functions in the stationary phase of the yeast Saccharomyces cerevisiae. J Biol Chem 273:29915-22
6. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG (1992) Overexpression of a transporter gene in a multidrug resistant human lung cancer line. Science 258:1650-1654
7. Collinson EJ, Wheeler GL, Garrido EO, Avery AM, Avery SV, Grant CMJ (2002) The yeast glutaredoxins are active as glutathione peroxidases. J Biol Chem 277:16712-167217
8. Decottignies A, Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15:137-144
9. Decottignies A, Grant AM Nichols JW, de Wet H, McIntosh DB, Goffeau A, (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein YOR1. J Biol Chem 273:12612-12622
10. Decottignies A, Owsianik, G, Ghislain M (1999) Casein kinase I dependent phosphorylation and stability of the yeast multidrug transporter Pdr5p. J. Biol Chem 274:37139-37146
11. Guarente L, Ptashne M (1981) Fusion of the Escherichia coli lacZ to the cytochrome C gene of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 78:2199-2203
12. Guetsova ML, Lecoq K, Daignan-Fornier B (1997) The isolation and characterization of S. cerevisiae mutants that constitutively express purine biosynthetic genes. Genetics 147:383-397
13. Hayes JD, Pulford DJ (1995) The glutathione S-transferase super-gene family: regulation of GSTs and contribution of the isoenzymes to cancer, chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30:445-600
14. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17:463-8
15. Jakoby WB (1978) The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv Enzymol 46:383-414
16. Katzmann D, Hallstrom T, Voet M, Wysock W, Golin J, Volckaert GK, Moye-Rowley WS (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15:6875-6883
17. Kelly SL, Lamb DC, Kelly DE (1997)Sterol 22-desaturase, cytochrome P45061, possesses activity in xenobiotic metabolism. FEBS Lett 412:233-235
18. King DJ, Wiseman A, Kelly DE, and Kelly SL (1985) Differences in the cytochrome P-450 mutants of S. cerevisiae. Curr Genet 10:261-7
19. Klein M, Mamnun YM., Eggmann T, Schuller C, Wolfger H, Martinoia E, Kuchler K (2002) The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast. FEBS Lett 520:63-67
20. Lee J, Godon C, Lagniel G, Spector D, Garin J, Labarre J, Toledano MB (1999) Yap1 and Skn7 control two specialized oxidative stress regulons in yeast. J. Biol Chem 274:16040-16046
21. Li Z.-S, Szczypka M, Lu Y-P, Thiele DJ, Rea PA (1996) The yeast cadmium factor protein, YCF1, is a vacuolar glutathione S-conjugate pump. J Biol Chem 271:6509-6517
22. Manolson MF, Proteau D, Preston RA, Stenbit A, Roberts BT, Hoyt MA, Preuss D, Mulholland J, Botstein D, Jones EW (1992) The VPH1 gene encodes a 95-kDa integral membrane polypeptide required for in vivo assembly and activity of the yeast vacuolar H(+)-ATPase. J Biol Chem 267:14294-142303
23. Ortiz DF, St.Pierre MV, Abdulmessih A, Irias IM (1997) A yeast ATP-binding casette-type protein mediating Bile acid Transport. J Biol Chem 272:15358-15365
24. Petrovic S, Pascolo L, Gallo R, Cupelli F, Ostrow, J.D., Goffeau A, Tiribelli C, Bruschi, CV (2000) The products of YCF1 and YLL015w (BPT1) cooperate for the ATP-dependant vacuolar transport of unconjugated bilirubin in Saccharomyces cerevisiae. Yeast 16:561-571
25. Robinson LC, Menold MM, Garrett S, Culbertson M (1993) Casein kinase I-like protein kinases encoded by YCK1 and YCK2 are required for yeast morphogenesis. Mol Cell Biol. 13:2870-81
26. Rogers B, Decottignies A, Kolaczkowski M, Carvajal E, Balzi E, Goffeau A. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3:207-14
27. Sharma KG, Sharma V, Bourbouloux A, Delrot S, Bachhawat AK (2000) Delayed growth stasis upon glutathione depletion in Saccharomyces cerevisiae: Evidence for an overlapping role played by thioredoxin. Curr Genet 38:71-77
28. Sharma KG, Mason DL, Liu G, Rea PA, Bachhawat AK, Michaelis S (2002) Localization, regulation and substrate transport properties of Bpt1p, a Saccharomyces cerevisiae MRP-type ABC transporter. Eukaryotic Cell 1:391-400
29. Taglicht D, Michaelis S (1998) Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease. Methods Enzymol 292:130-162
30. Wach A, Brachat A, Pohlman R, Philippsen P (1994) New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae. Yeast 10:1793-1808
31. Wemmie JA, Szczypka, MS, Thiele, DJ, Moye-Rowley WS (1994) Cadmium tolerance by the yeast AP-1 protein requires the presence of an ATP-binding casette transporter-encoding gene YCF1. J Biol Chem 269:32592-32597