The role of the glutamatergic system in alcohol addiction;Die rolle des glutamatergen systems bei alkoholsucht

Fortschritte der Neurologie Psychiatrie

Volumn 71, Issue SUPPL. 1, 2003, Pages

  Spanagel, Rainer ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OPIATE;

ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL BEHAVIOR; ARTICLE; CLINICAL PATHWAY; DISEASE MODEL; HUMAN; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATHOPHYSIOLOGY; RECEPTOR AFFINITY; RELAPSE; STRESS;

ALCOHOLISM; ANIMALS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; NEUROTRANSMITTER AGENTS; RECEPTORS, N-METHYL-D-ASPARTATE; RECURRENCE;

EID: 0043158743     PISSN: 07204299     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Spanagel R, Hölter SM. Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcoholism 1999; 34: 231-243
2. Burish TG, Maisto SA, Cooper AM, Sobell MB. Effects of voluntary short-term abstinence from alcohol on subsequent drinking patterns of college students. J Stud Alcohol 1981; 42: 1013-1020
3. Wolffgramm J, Heyne A. From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 1995; 70: 77-94
4. Sass H, Soyka M, Mann K, Zieglgänsberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 1996; 53: 673-680
5. O'Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville B. Naltrexone and coping skills therapy for alcohol dependence. A controlled study. Arch Gen Psychiatiatry 1992; 49: 881-887
6. Spanagel R, Hölter S, Allingham K, Landgraf R, Zieglgänsberger W. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacology 1996; 305: 39-44
7. Hölter SM, Spanagel R. Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology 1999; 145: 360-369
8. Spanagel R, Bienkowski P. Glutamatergic mechanisms in alcohol dependence and addiction. In: Lodge D, Danysz W, Parsons CG (Hrsg): Therapeutic Potential of Ionotropic Glutamate Receptor Antagonists and Modulators. FP Graham Publishing Co, 2002 (in press)
9. Hundt W, Hölter SM, Spanagel R. Discriminative stimulus effects of glutamate release inhibitors in rats trained to discriminate ethanol. Pharmacol Biochem Behav 1998; 59: 691-695
10. Spanagel R. The role of the glutamate cGMP pathway in alcohol dependence. Pharmacologist 2002; 44: 3
11. Bormann J. Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. Eur J Pharmacology 1989; 166: 591-592
12. Kornhuber J, Weller M. Psychotogenicity and NMDA receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry 1997; 41: 135-144
13. Hölter SM, Danysz W, Spanagel R. Evidence for alcohol anti-craving properties of memantine. Eur J Pharmacology 1996; 314: 1-2
14. Hölter SM, Danysz W, Spanagel R. The non-competitive NMDA receptor antagonist MRZ 2/579 suppresses the alcohol deprivation effect in long-term alcohol drinking rats and substitutes the alcohol cue in a discrimination task. J Pharmacol Exp Ther 2000; 292: 545-552