Update on Novo Nordisk's clinical trial programme on NovoSeven®

Blood Coagulation and Fibrinolysis

Volumn 14, Issue SUPPL. 1, 2003, Pages

  Dejgaard, Anders ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Clinical trials; Indications; Recombinant activated factor VII

Indexed keywords

BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 9; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

BLEEDING; BLOOD TRANSFUSION; BRAIN HEMORRHAGE; BRAIN INJURY; CLINICAL TRIAL; CONFERENCE PAPER; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HEMOPHILIA; HUMAN; LETHALITY; LIVER RESECTION; LIVER TRANSPLANTATION; PEROPERATIVE COMPLICATION; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROPHYLAXIS; REGULATORY MECHANISM; SIDE EFFECT; STEM CELL TRANSPLANTATION; TREATMENT INDICATION; UPPER GASTROINTESTINAL BLEEDING;

BLOOD COAGULATION DISORDERS; BLOOD LOSS, SURGICAL; CLINICAL TRIALS, PHASE II; FACTOR VII; HEMORRHAGE; HEMOSTATICS; HUMANS; LIVER DISEASES; MULTICENTER STUDIES; RANDOMIZED CONTROLLED TRIALS; RECOMBINANT PROTEINS; SAFETY; THROMBOSIS;

EID: 0043127159     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001721-200306001-00010     Document Type: Conference Paper

References (16)

1. Martinowitz U, Kenet G, Segal E, Luboshitz J, Lubetsky A, Ingerslev J, Lynn M. Recombinant activated factor VII for adjunctive hemorrhage control in trauma. J Trauma 2001; 51:431-438.
2. Hunault M, Bauer KA. Recombinant factor VIIa for the treatment of congenital factor VII deficiency. Semin Thromb Hemost 2000; 26:401-405.
3. Moisescu E, Ardelean L, Simion I, Muresan A, Ciupan R. Recombinant factor VIIa treatment of bleeding associated with acute renal failure. Blood Coagul Fibrinolysis 2000; 11:575-577.
4. Vlot AJ, Ton E, Mackay AJ, Kramer MH, Gaillard CA. Treatment of a severely bleeding patient without preexisting coagulopathy with activated recombinant factor VII. Am J Med 2000; 108:421-423.
5. Holm M, Andreasen R, Ingerslev J. Management of bleeding using recombinant factor VIIa in a patient suffering from bleeding tendency due to a lupus anticoagulant-hypoprothrombinemia syndrome. Thromb Haemost 1999; 82:1776-1778.
6. Liem AK, Biesma DH, Ernst SM, Schepens AA. Recombinant activated factor VII for false aneurysms in patients with normal haemostatic mechanisms. Thromb Haemost 1999; 82:150-151.
7. Mariani G, Testa MG, Di Paolantonio T, Molskov BR, Hedner U. Use of recombinant, activated factor VII in the treatment of congenital factor VII deficiencies. Vox Sang 1999; 77:131-136.
8. Muleo G, Santoro R, Iannaccaro PG, Papaleo P, Leo F, Zappala D, Elia L. Small doses of recombinant factor VIIa in acquired deficiencies of vitamin K dependent factors. Blood Coagul Fibrinolysis 1999; 10:521-522.
9. Poon MC, Demers C, Jobin F, Wu JW. Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia. Blood 1999; 94:3951-3953.
10. Meijer K, Sieders E, Slooff MJ, De Wolf JT, Van Der Meer J. Effective treatment of severe bleeding due to acquired thrombocytopathia by single dose administration of activated recombinant factor VII. Thromb Haemost 1998; 80:204-205.
11. Peters M, Heijboer H. Treatment of a patient with Bernard-Soulier syndrome and recurrent nosebleeds with recombinant factor VIIa. Thromb Haemost 1998; 80:352.
12. Revesz T, Arets B, Bierings M, van den BC, Duval E. Recombinant factor VIIa in severe uremic bleeding. Thromb Haemost 1998; 80:353.
13. Ingerslev J, Knudsen L, Hvid I, Tange MR, Fredberg U, Sneppen O. Use of recombinant factor VIIa in factor-VII-deficient patients. Haemophitia 1997; 3:215-218.
14. Bernstein DE, Jeffers L, Erhardtsen E, Reddy KR, Glazer S, Squiban P, et al. Recombinant factor VIIa corrects prothrombin time in cirrhotic patients: a preliminary study. Gastroenterology 1997; 113:1930-1937.
15. Kristensen J, Killander A, Hippe E, Helleberg C, Ellegard J, Holm M, et al. Clinical experience with recombinant factor VIIa in patients with thrombocytopenia. Haemostasis 1996; 26(Suppl 1):159-164.
16. Rice KM, Savidge GF. NovoSeven (recombinant factor VIIa) in central nervous systems bleeds. Haemostasis 1996; 26(Suppl 1):131-134.