The regulation and its mechanism of DHPs calcium antagonist on rat stomach fundus smooth muscle cell proliferation induced by 5-HT

Chinese Pharmacological Bulletin

Volumn 19, Issue 7, 2003, Pages 796-800

  Liu, Li Hong ^a   Mei, Qi Bing ^a   Zhang, Feng ^a   Chen, Lei ^a   Zhao, De Hua ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

5 HT; DHPs calcium antagonist; Proliferation; Rat stomach fundus smooth muscle cells

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 4 (3 NITROPHENYL) 3,5 PYRIDINEDICARBOXYLIC ACID METHYL PENTYL ESTER; CALCIUM ANTAGONIST; CALCIUM ION; DNA; LACIDIPINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN P44; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL VIABILITY; ENZYME ASSAY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NONHUMAN; RAT; SMOOTH MUSCLE FIBER; STOMACH FUNDUS;

EID: 0043068253     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Yuan QX, Mcroberts JA, Lakshmanan J et al. Newborn rabbit gastric smooth muscle cell culture: EGF and TGF-alpha are potent mitogens. J Pediatr Gastroenterol Nutr, 1993;17:153-60
2. Lee SL, Wang WW, Finlay GA et al. Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion. Am J Physiol, 1999;277(2pt1):282-91
3. 1B receptors coupled to a Gi-protein. Nature, 1988;335:254-6
4. Canan GN, Jean-Marie L, Pierre H et al. 5-Hydroxytryptamin 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways. Proc Natl Acad Sci, 2000;97:2591 -6
5. Loric S, Maroteaux L, Kellermann O, Launay JM. Functional serotonin-2B receptors are expressed by a teratocarcinoma-derived cell line during serotoninergic differentiation. Mol Pharmacol 1995;47:458-66
6. 2B receptor. J Biol Chem, 1996;271:3141-7
7. Buckner CK, Dea D, Liberati N. A pharmacologic examination of receptors mediating serotonin-induced bronchoconstriction in the anesthetized guinea pig. J Pharmacol Exp Ther, 1991;257: 26-34
8. Rafferty P, Beasley R, Holgate ST. The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5′ monophosphate in atopic asthma. Am Rev Respit Dis, 1987;136:369-73
9. Lee SL, Wang WW, Lanzillo TJ et al. Regulation of serotonin-induced DNA synthesis of bovine pulmonary artery smooth muscle cell. Am J Physiol, 1994;266(1):53-60
10. 2A receptor. Ann N Y Acad Sci, 1998; 861:162-8
11. Paunesku T, Mittal S, Protic M et al. Proliferating cell nuclear antigen(PCNA): Ringmaster of the genome. Int J Radiat Biol, 2001;77:1007-21
12. Xu C, Yin C, Wang S. Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury. Chin Med J (Engl), 2001;114: 571-6
13. Ringerike T, Blystad FD, Levy FO et al. Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae. J Cell Sci, 2002;115: 1331-40