Reversion of UVC-induced tumorigenic human hybrid cells to the non-tumorigenic phenotype

European Journal of Cancer

Volumn 32, Issue 2, 1996, Pages 322-327

  Sun, C ^a   Antonionio, R J ^a   Redpath, J L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Epigenetics; Genetic instability; Morphologic and tumorigenic reversion

Indexed keywords

ALKALINE PHOSPHATASE; TUMOR ANTIGEN;

ARTICLE; CARCINOGENICITY; CELL CULTURE; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; HYBRID CELL; MORPHOLOGY; MUTANT; PHENOTYPE; PRIORITY JOURNAL; TUMOR GROWTH; ULTRAVIOLET C RADIATION;

ALKALINE PHOSPHATASE; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; FIBROBLASTS; HELA CELLS; HUMANS; HYBRID CELLS; KINETICS; MODELS, BIOLOGICAL; PHENOTYPE; ULTRAVIOLET RAYS;

EID: 0043042251     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00581-1     Document Type: Article

References (24)

1. Boyd JA, Barrett JC. Genetic and cellular basis of multistep carcinogenesis. Pharmacol Ther 1990, 46, 469-486.
2. Bishop JM. Molecular themes in oncogenesis. Cell 1991, 64, 235-248.
3. Stanbridge EJ. Human tumor suppressor genes. Annu Rev Genet 1990, 24, 615-657.
4. Rubin H. Epigenetic nature of neoplastic transformation. In Hodges GM, Rowlatt C, eds. Developmental Biology and Cancer. Florida, CRC Press, 1994, 61-84.
5. Loeb LA. Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991, 51, 3075-3079.
6. Farber E, Rubin H. Cellular adaptation in the origin and development of cancer. Cancer Res 1991, 51, 2751-2761.
7. Kennedy AR, Little JB. Evidence that a second event in X-ray-induced oncogenic transformation in vitro occurs during cellular proliferation. Radiat Res 1984, 99, 228-248.
8. Kennedy AR. The conditions for the modification of radiation transformation in vitro by a tumor promoter and protease inhibitors. Carcinogenesis 1985, 6, 1441-1445.
9. Mendonca MS, Antonionio RJ, Redpath JL. Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells. Radiat Res 1993, 134, 209-216.
10. Brouty-Boye' D, Gresser I, Balwin C. Reversion of the transformed phenotype to the parental phenotype by subcultivation of X-ray transformed C3H/10T1/2 cells at low cell density. Int J Cancer 1979, 24, 253-260.
11. Rubin AL, Yao A, Rubin H. Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells. Proc Natl Acad Sci USA 1990, 87, 10 005-10 009.
12. Lavrovsky VA, Guvakova MA, Lavrovsky YV. High frequency of tumour cell reversion to non-tumorigenic phenotype. Eur J Cancer 1992, 28, 17-21.
13. Latham KM, Stanbridge EJ. Identification of the HeLa tumor-associated antigen, p75/150, as intestinal alkaline phosphatase and evidence for its transcriptional regulation. Proc Natl Acad Sci USA 1990, 87, 1263-1267.
14. Srivatsan ES, Benedict WF, Stanbridge EJ. Implication of chromosome 11 in the suppression of neoplastic expression in human cell hybrids. Cancer Res 1986, 46, 6174-6179.
15. Sun C, Redpath JL, Colman M, Stanbridge EJ. Further studies on the radiation-induced expression of a tumor-specific antigen in human cell hybrids. Radiat Res 1988, 114, 84-93.
16. Stanbridge EJ, Flandemeyer RR, Daniels DW, Nelson-Rees WA. Specific chromosome loss associated with expression of tumorigenicity in human cell hybrids. Somat Cell Genet 1981, 7, 699-712.
17. Russell WC, Newman C, Williamson DH. A simple cytochemical technique for demonstration of DNA in cells infected with mycoplasma and viruses. Nature 1975, 253, 461-462.
18. Redpath JL, Sun C. UVC-induced expression of a tumor-associated antigen in human cell hybrids (HeLa x skin fibroblasts): repair of potentially lethal and potentially transforming damage. Carcinogenesis 1989, 10, 723-726.
19. Stanbridge EJ, Der CJ, Doerson CJ, et al. Human cell hybrids: analysis of transformation and tumorigenicity. Science 1982, 215, 252-259.
20. Der CJ, Stanbridge EJ. A tumor-specific membrane phosphoprotein marker in human cell hybrids. Cell 1981, 26, 429-438.
21. Bicknell DC, Sutherland DR, Stanbridge EJ, Greaves MF. Monoclonal antibodies specific for a tumor-associated membrane phosphoprotein in human cell hybrids. Hybridoma 1985, 4, 143-152.
22. Mendonca MS, Antonionio RJ, Latham KM, Stanbridge EJ, Redpath JL. Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of γ-irradiated HeLa x fibroblast cell hybrids. Cancer Res 1991, 51, 4455-4462.
23. Mendonca MS, Fasching CL, Srivatsan ES, Stanbridge EJ, Redpath JL. Loss of a putative tumor suppressor locus after gamma-ray-induced neoplastic transformation of HeLa x skin fibroblast human hybrid cells. Radiat Res 1995, 143, 34-44.
24. Latham KM, Stanbridge EJ. Examination of the oncogenic potential of a tumor-associated antigen, intestinal alkaline phosphatase, in HeLa x Fibroblast hybrids. Cancer Res 1992, 52, 616-622.