L-DOPA biotransformation: Correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients

Journal of Neural Transmission

Volumn 110, Issue 8, 2003, Pages 899-910

  Dousa, M K ^a   Weinshilboum, R M ^a   Muenter, M D ^b   Offord, K P ^a   Decker, P A ^a   Tyce, G M ^a  

^a MAYO CLINIC   (United States)

^b MAYO CLINIC   (United States)

Author keywords

3 phosphoadenosine 5 phosphosulfate; L DOPA absorption; L DOPA:biotransformation; L DOPA:pharmacogenomics; S adenosyl L methionine

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; AMANTADINE; ARYL SULFOTRANSFERASE; ATENOLOL; CARBIDOPA PLUS LEVODOPA; CATECHOL METHYLTRANSFERASE; CONJUGATED ESTROGEN; DIAZEPAM; DIAZIDE; DIPYRIDAMOLE; FUROSEMIDE; INDOMETACIN; LEVODOPA; METOPROLOL TARTRATE; PROPRANOLOL; SULINDAC;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CORRELATION ANALYSIS; DOPAMINE METABOLISM; DRUG ABSORPTION; DRUG DOSE REGIMEN; DRUG METABOLISM; DRUG SULFATION; DRUG TRANSFORMATION; DRUG URINE LEVEL; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MALE; METHYLATION; PARKINSON DISEASE; PRIORITY JOURNAL; THROMBOCYTE;

ADENOSINE DIPHOSPHATE; AGED; ARYLSULFOTRANSFERASE; BIOTRANSFORMATION; BLOOD PLATELETS; CARBIDOPA; CATECHOL O-METHYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ERYTHROCYTES; FEMALE; HUMANS; LEVODOPA; MALE; METHYLATION; MIDDLE AGED; PARKINSON DISEASE; S-ADENOSYLMETHIONINE; SULFATES;

EID: 0043031248     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0001-2     Document Type: Article

References (18)

1. Campbell NRC, Dunnette JH, Mwaluko G, Van Loon J, Weinshilboum RM (1984) Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Clin Pharmacol Ther 35: 55-63
2. Her C, Aksoy LA, Weinshilboum RM (1994) Estrogen sulfotransferase (EST): human gene structure and chromosomal localization. Can J Physiol Pharmacol 72 [Suppl 1]: 311
3. Muenter MD, Dousa MK, Weinshilboum RM, Tyce GM (1992) Sulfation, O-methylation and oxidative deamination in the short- and long-duration response to levodopa/ carbidopa in Parkinson's disease. Neurology 42 [Suppl 3]: 442
4. Muskier FAJ, Fremouw-Ottevangers DC, van der Meulen J, Wolthers BG, de Vries JA (1978) Determination of some L-3-4-dihydroxyphenylalanine and dopamine metabolites in urine by means of mass fragmentography. Clin Chem 24: 122-127
5. Price RA, Cox NJ, Spielman RS, Van Loon J, Maidak BL, Weinshilboum RM (1985) Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity. Genet Epidemiol 5: 1-15
6. Raymond FA, Weinshilboum RM (1975) Microassay of human erythrocyte catechol-O-methyltransferase: removal of inhibitory calcium with chelating resin. Clin Chim Acta 58: 185-194
7. Rutledge CO, Hoehn MM (1973) Sulphate conjugation and L-Dopa treatment of Parkinson's patients. Nature 244: 447-450
8. Sharpless NS, Muenter MD, Tyce GM, Owen CA Jr (1972) 3-Methoxy-4-hydroxyphenylalanine (3-O-methyldopa) in plasma during oral L-dopa therapy of patients with Parkinson's disease. Clin Chim Acta 37: 359-363
9. Sharpless NS, Tyce GM, Muenter MD, Dinapoli RD (1974) Dopa, 3-O-methyldopa and metabolites in urine during oral L-3-O-methyldopa therapy. Clin Pharmacol Ther 16: 770-781
10. Smythies J, Galzigna L (1998) The oxidative metabolism of catecholamines in the brain: a review. Biochim Biophys Acta 1380: 159-162
11. Tyce GM, Owen CA Jr (1973) Effect of aromatic L-amino acid decarboxylase inhibition on metabolism of dihydroxyphenylalanine by the isolated perfused rat liver. Biochem Pharmacol 21: 2977-2989
12. Tyce GM, Sharpless NS, Muenter MD (1974) Free and conjugated dopamine in plasma during L-dopa therapy. Clin Pharmacol Ther 16: 782-788
13. Tyce GM, Dousa MK, Muenter MD (1990) MAO and L-DOPA treatment of Parkinson's disease. J Neural Transm 29: 233-239
14. Weinshilboum RM, Raymond FA (1976) Calcium inhibition of rat liver catechol O-methyltransferase. Biochem Pharmacol 25: 573-579
15. Weinshilboum RM, Raymond FA (1987) Inheritance of low erythrocyte catechol-O-methyltransferase activity in man. Am J Hum Genet 29: 125-135
16. Weinshilboum RM, Otterness DM, Szumlanski CL (1999) Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase. Annu Rev Pharmacol Toxicol 39: 19-52
17. Woitalia D, Saft C, Miller T, Kuhn W, Przuntek H (1998) Cost effectiveness of L-Dopa - serum concentration determination. Mov Disord 13 [Suppl 2]: 186
18. Wood TC, Aksoy LA, Aksoy S, Weinshilboum RM (1994) Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization. Biochem Biophys Res Commun 198: 1119-1127