Restoration of self-sustained circadian rhythmicity by the mutant Clock allele in mice in constant illumination

Journal of Biological Rhythms

Volumn 17, Issue 6, 2002, Pages 520-525

  Spoelstra, K ^a,c   Oklejewicz, M ^b   Daan, S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b INSERM   (France)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Circadian clock; Circadian rhythmicity; Clock; Constant illumination; Mouse mutants

Indexed keywords

GENE PRODUCT;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL RHYTHM; CHIMERA; CIRCADIAN RHYTHM; CONTINGENT NEGATIVE VARIATION; CONTROLLED STUDY; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; LIGHT DARK CYCLE; MOUSE; NONHUMAN; PHOTORECEPTOR; PROTEIN DOMAIN;

ALLELES; ANIMALS; CIRCADIAN RHYTHM; GENOTYPE; LIGHT; MICE; MICE, MUTANT STRAINS; MUTATION; PHOTOPERIOD; TRANS-ACTIVATORS;

ANIMALIA;

EID: 0042999387     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748730402238234     Document Type: Article

References (19)

1. Antoch MP, Song EJ, Chang AM, Vitaterna MH, Zhao Y, Wilsbacher LD, Sangoram AM, King DP, Pinto LH, and Takahashi JS (1997) Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 89:655-667.
2. Aschoff J (1960) Exogenous and endogenous components in circadian rhythms. Cold Spring Harbor Symp Quant Biol 25:11-28.
3. Challet E, Thakahashi JS, and Turek FW (2000) Nonphotic phase-shifting in Clock mutant mice. Brain Res 859:398-403.
4. Daan S, Merrow M, and Roenneberg T (2002) External time - internal time. J Biol Rhythms 17:107-109.
5. Daan S and Pittendrigh CS (1976) A functional analysis of circadian pacemakers in nocturnal rodents III: Heavy water and constant light: Homeostasis of frequency? J Comp Physiol 106:267-290.
6. Gekakis N, Staknis D, Nguyen HB, Davis FC, Wilsbacher LD, King DP, Takahashi JS, and Weitz CJ (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280:1564-1568.
7. King DP and Takahashi JS (2000) Molecular genetics of circadian systems in mammals. Ann Rev Neurosci 23:713-742.
8. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, and Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205.
9. Lowrey PL and Takahashi JS (2000) Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Ann Rev Genetics 34:533-562.
10. Low-Zeddies SS and Takahashi JS (2001) Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior. Cell 105:25-42.
11. Nakamura W, Honma S, Shirakawa T, and Honma KI (2002) Clock mutation lengthens the circadian period without damping rhythms in individual SCN neurons. Nat Neurosci 5:399-400.
12. Pittendrigh CS (1981) Circadian systems: Entrainment. In Handbook Behavioral Neurobiology: Vol. 4. Biological Rhythms, J Aschoff, ed, pp 94-124, Plenum, New York.
13. Ripperger JA, Shearman LP, Reppert SM, and Schibler U (2000) CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP. Genes Dev 14:679-689.
14. Roenneberg T and Foster RG (1997) Twilight times: Light and the circadian system. Photochem Photobiol 66:549-561.
15. Shearman LP and Weaver DR (1999). Photic induction of Period gene expression is reduced in Clock mutant mice. NeuroReport 10:613-618.
16. Sokolove PG and Bushell WN (1978) The chi square periodogram: Its utility for analysis of circadian rhythms. J Theor Biol 72:131-160,
17. Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, Dove WF, Pinto LH, Turek FW, and Takahashi JS (1994) Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-725.
18. Wever RA (1966) En mathematisches Modell für die circadiane Periodik. Zeitschrift für angewandte Mathematik und Mechanik Sonderheft 46:148-157.
19. Yamaguchi S, Mitsui S, Yan L, Yagita K, Miyake S, and Okamura H (2000) Role of DBP in the circadian oscillatory mechanism. Mol Cell Biol 20:4773-4781.