Q: Is there a role for metformin or acarbose as a weight-loss agent in the absence of diabetes?

Cleveland Clinic Journal of Medicine

Volumn 70, Issue 8, 2003, Pages 702-704

  Siraj, Elias S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; BIGUANIDE DERIVATIVE; CARBOHYDRATE; GLUCOSE; INSULIN; METFORMIN; PLACEBO; SULFONYLUREA; ANTIDIABETIC AGENT;

ARTICLE; BODY FAT; CLINICAL TRIAL; DIABETES MELLITUS; DIET THERAPY; DRUG EFFICACY; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; STOMACH EMPTYING; WEIGHT REDUCTION; DRUG EFFECT; PHYSIOLOGY; REVIEW;

ACARBOSE; DIABETES COMPLICATIONS; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; OBESITY; WEIGHT LOSS;

EID: 0042976521     PISSN: 08911150     EISSN: None     Source Type: Journal    
DOI: 10.3949/ccjm.70.8.702     Document Type: Article

References (7)

1. Lee A, Morley JE. Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. Obes Res 1998; 6:47-53.
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3. Glueck CJ, Fontaine RN, Wang P, et al. Metformin reduces weight, centripetal obesity, insulin, leptin, and low-density lipoprotein cholesterol in nondiabetic, morbidly obese subjects with body mass index greater than 30. Metabolism 2001; 50:856-861.
4. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346:393-403.
5. Ranganath L, Norris F, Morgan L, Wright J, Marks V. Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycemic effect. Diabetes Med 1998; 15:120-124.
6. Bayraktar F, Hamulu F, Ozgen AG, Yilmaz C, Tuzun M, Kabalak T. Acarbose treatment in obesity: qa coantrolled study. Eat Weight Disord 1998; 3:46-49.
7. Hauner H, Petzinna D, Sommerauer B, Toplak H. Effect of acarbose on weight maintenance after dietary weight loss in obese subjects. Diabetes Obes Metab 2001; 3:423-427.