Influence of grapefruit juice on the plasma concentration of efonidipine hydrochloride (Landel®)

Japanese Pharmacology and Therapeutics

Volumn 31, Issue 7, 2003, Pages 579-588

  Yajima, Youichi ^a   Iijima, Hajime ^a   Yokoyama, Renzo ^a  

^a NONE

Author keywords

Drug interaction; Efonidipine hydrochloride; Grapefruit juice; Landel ; Pharmacokinetics

Indexed keywords

CALCIUM ANTAGONIST; EFONIDIPINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISEASE SEVERITY; DRUG BLOOD LEVEL; FEVER; FOOD DRUG INTERACTION; GRAPEFRUIT JUICE; HEADACHE; HEART RATE; HUMAN; MALAISE; MALE; NOSE SECRETION; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; TABLET; THORAX PAIN; TONSILLITIS; TRIACYLGLYCEROL BLOOD LEVEL; VERTIGO;

EID: 0042972970     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Miniscalco A, Lundahl J, Regardh CG, et al. Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Pharmacol Exp Ther 1992; 261: 1195-9.
2. 1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis 1990; 11: 2275-9.
3. Rashid TJ, Martin U, Clarke H, et al. Factors affecting the absolute bioavailability of nifedipine. Br J Clin Pharmacol 1995; 40: 51-8.
4. Bailey DG, et al. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991; 337: 268-9.