Synthesis of both enantiomers of a P-chirogenic 1,2-bisphospholanoethane ligand via convergent routes and application to rhodium-catalyzed asymmetric hydrogenation of CI-1008 (pregabalin)

Journal of the American Chemical Society

Volumn 125, Issue 34, 2003, Pages 10219-10227

  Hoge, Garrett ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOMERS;

CATALYSIS; HYDROGENATION; INORGANIC ACIDS; RHODIUM; SYNTHESIS (CHEMICAL);

ORGANIC COMPOUNDS;

1,2 BISPHOSPHOLANOETHANE; ACETAMIDOACRYLIC ACID DERIVATIVE; ACRYLIC ACID DERIVATIVE; BORANE DERIVATIVE; LIGAND; PREGABALIN; RHODIUM COMPLEX; SPARTEINE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHIRALITY; CRYSTAL STRUCTURE; DEPROTECTION REACTION; ENANTIOMER; ENANTIOSELECTIVITY; HYDROGENATION; PRESSURE; REACTION ANALYSIS; STEREOCHEMISTRY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ACRYLATES; ANTICONVULSANTS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ETHANE; GAMMA-AMINOBUTYRIC ACID; HYDROGEN; LIGANDS; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PRESSURE; RHODIUM; STEREOISOMERISM;

EID: 0042932780     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja034715o     Document Type: Article

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