Effective graft-versus-leukaemia effect after allogeneic stem cell transplantation using reduced-intensity preparative regimens in Fanconi anaemia patients with myelodysplastic syndrome or acute myeloid leukaemia

British Journal of Haematology

Volumn 122, Issue 5, 2003, Pages 806-809

  Guardiola, Philippe ^a,b   Kurre, Peter ^b   Vlad, Amalia ^a   Cayuela, Jean Michel ^c   Espérou, Hélène ^a   Devergie, Agnès ^a   Ribaud, Patricia ^a   Socié, Gérard ^a   Richard, Patrice ^a   Traineau, Richard ^a   Storb, Rainer ^b   Gluckman, Eliane ^a  

^a SAINT LOUIS HOSPITAL   (France)

^b Fred Hutchinson Cancer Research Center   (United States)

^c Laboratoire Central d'Hematologie   (France)

Author keywords

Acute leukaemia; Allogeneic stem cell transplantation; Fanconi anaemia; Graft versus leukaemia effect; Myelodysplasia

Indexed keywords

CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ANAMNESIS; ARTICLE; BLOOD EXAMINATION; BONE MARROW BIOPSY; BONE MARROW EXAMINATION; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL FEATURE; CORTICOSTEROID THERAPY; DEATH; FANCONI ANEMIA; FEMALE; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOLOGIC MALIGNANCY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; LABORATORY TEST; MYELODYSPLASIA; MYELODYSPLASTIC SYNDROME; PATIENT COMPLIANCE; PRIORITY JOURNAL; RELAPSE; REMISSION; SCHOOL CHILD; SKIN DEFECT; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ACUTE DISEASE; ADULT; CHILD; FANCONI ANEMIA; FATAL OUTCOME; FEMALE; GRAFT VS LEUKEMIA EFFECT; HUMANS; LEUKEMIA, MYELOID; MYELODYSPLASTIC SYNDROMES; REOPERATION; STEM CELL TRANSPLANTATION; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 0042913496     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04503.x     Document Type: Article

References (12)

1. Auerbach, A.D. & Woman, S.R. (1975) Susceptibility of Fanconi fibroblasts to chromosome damage by carcinogens, Nature, 261, 494-496.
2. Gluckman, E., Devergie, A. & Dutreix, J. (1983) Radiosensitivity in Fanconi anaemia: application to the conditioning regimen for bone marrow transplantation. British Journal of Haematology, 54, 431-440.
3. Gluckman, E., Auerbach, A.D., Horowitz, M.M., Sobocinski, K.A., Ash, R.C., Bortin, M.M., Butturini, A., Camitta, B.M., Champlin, R.E. & Friedrich, W. (1995) Bone marrow transplantation for Fanconi anemia. Blood, 86, 2856-2862.
4. Guardiola, P., Pasquini, R., Dokal, I., Ortega, J.J., van Weel-Sipman, M., Marsh, J.C.W., Ball, S.E., Locatelli, F., Vermylen, C., Skinner, R., Ljungman, P., Miniero, R., Shaw, P.J., Souillet, G., Michallet, M., Bekassy, A.N., Krivan, G., Di Bartolomeo, P., Heilmann, C., Zanesco, L., Cahn, J.Y., Arcese, W., Bacigalupo, A. & Gluckman, E. (2000) Outcome of 69 allogeneic stem cell transplantations for Fanconi anemia using HLA-matched unrelated donors: a study on behalf of the European Group for Blood and Marrow Transplantation. Blood, 95, 422-429,
5. Kapelushnik, J., Or, R., Slavin, S. & Nagler, A. (1997) A fludarabine-based protocol for bone marrow transplantation in Fanconi's anemia. Bone Marrow Transplantation, 20, 1109-1110.
6. Kurre, P., Pulsipher, M., Woolfrey, A., Maris, M., Sandmaier, B., Kiem, H.P. & Storb, R. (2003) Reduced toxicity and prompt engraftment following minimal conditioning of a patient with Fanconi anemia undergoing stem cell transplantation from an HLA-matched unrelated donor. Journal of Pediatric Hematology/Oncology, 7, 581-583.
7. McCloy, M., Almeida, A., Daly, P., Vulliamy, T., Roberts, I.A. & Dokal, I. (2001) Fludarabine-based stem cell transplantation protocol for Fanconi's anaemia in myelodysplastic transformation. British Journal of Haematology, 112, 427-429.
8. McSweeney, P.A., Niederwieser, D., Shizuru, J.A., Sandmaier, B.M., Molina, A.J., Maloney, D.G., Chauncey, T.R., Gooley, T.A., Hegenbart, U., Nash, R.A., Radich, J., Wagner, J.L., Minor, S., Appelbaum, F.R., Bensinger, W.I., Bryant, E., Plowers, M.E., Georges, G.E., Grumet, F.C., Kiem, H.P. & Torok-Storb, B., Yu, C., Blume, K.G. & Storb, R.F. (2001) Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood, 97, 3390-3400.
9. de Medeiros, C.R., Silva, L.M. & Pasquini, R. (2001) Unrelated cord blood transplantation in a Fanconi anemia patient using fludarabine-based conditioning. Bone Marrow Transplantation, 28, 110-112.
10. Niederwieser, D., Maris, M., Shizuru, J.A., Petersdorf, E., Hegenbart, U., Sandmaier, B.M., Maloney, D.G., Storer, B., Lange, T., Channcey, T., Deininger, M., Ponisch, W., Anasetti, C., Woolfrey, A., Little, M.T., Blume, K.G., McSweeney, P.A. & Storb, R.F. (2003) Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases. Blood, 101, 1620-1629.
11. Ortega, M., Caballin, M.R., Ortega, J.J., Olive, T. & Coll, M.D. (2000) Follow-up by cytogenetics and fluorescent in situ hybridization analysis of allogeneic bone marrow transplantation in two children with Fanconi's anaemia in transformation. British Journal of Haematology, 111, 329-333.
12. Young, N.S. & Alter, B.P. (1994) Clinical features of Fanconi's anemia. In: Aplastic Anemia Acquired and Inherited (ed. by N.S. Young & B.P. Alter), pp. 275-309. Saunders, Philadelphia, PA.