The utility of the in situ detection of T-cell receptor beta rearrangements in cutaneous T-cell-dominant infiltrates

Diagnostic Molecular Pathology

Volumn 12, Issue 3, 2003, Pages 133-141

  Magro, Cynthia M ^a   Nuovo, Gerard J ^a,c   Crowson, A Neil ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b ST JOHN MEDICAL CENTER   (United States)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

In situ; PCR; RT; RT in situ PCR; T cell lymphoma; TCR

Indexed keywords

ARTICLE; CELL TRANSFORMATION; CLINICAL ARTICLE; CLONAL VARIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; GENE REARRANGEMENT; HISTOPATHOLOGIC SKIN REACTION; HUMAN; HUMAN TISSUE; LUPUS ERYTHEMATOSUS; LYMPHOCYTE CLONE; LYMPHOCYTIC INFILTRATION; LYMPHOMATOID PAPULOSIS; PANNICULITIS; PARAPSORIASIS; PITYRIASIS LICHENOIDES; PRIORITY JOURNAL; PURPURA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN CANCER; T CELL LYMPHOMA; T LYMPHOCYTE; TISSUE FIXATION;

EID: 0042889186     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200309000-00004     Document Type: Article

References (23)

1. Flug F, Pelicci PG, Bonetti F. T-cell receptor gene rearrangements as markers of lineage and clonality I T-cell neoplasms. Proc Natl Acad Sci U S A. 1985;82:3460-3464.
2. Bourguin A, Tung R, Galili N, et al. Rapid, nonradioactive detection of clonal T-cell receptor gene rearrangements in lymphoid neoplasms. Proc Natl Acad Sci U S A. 1990;87:8536-8540.
3. McCarthy K, Sloane JP, Kabarowski J, et al. The rapid detection of clonal T-cell porliferations in patients with lymphoid disorders. Am J Pathol. 1991;138:821-828.
4. Wood GS, Tung RM, Haeffner AC, et al. Detection of clonal T-cell receptor gene rearrangments in early mycosis fungoides/Sézary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR-DGGE). J Invest Dermatol. 1994;103:34-41.
5. Magro CM, Burns F, Kovatich A, et al. Lymphocytic lobular panniculitis: a clinical, histological, immunophenotypic and genotypic study of 40 cases. J Cutan Pathol. 2001;28:235-245.
6. Chott A, Vonderheid EC, Olbricht S, et al. The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. J Invest Dermatol. 1996;106:696-700.
7. Weiss LM, Wood GS, Ellisn LW. Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Haberman disease). Am J Pathol. 1987;126:417-421.
8. Magro CM, Morrison C, Kovatich A, et al. Pityriasis lichenoides is a cutaneous T-cell dyscrasia: a clinical, genotypic, and phenotypic study. Lab Invest. 2001;81:70A (abstr).
9. Toro JR, Sander CA, LeBoit PE. Persistent pigmented purpuric dermatitis and mycosis fungoides: simulant precursor or both? A study by light microscopic and molecular methods. Am J Dermatopathol. 1997;19:108-119.
10. Crowson AN, Magro CM. Atypical pigmentary purpura: A clinical, pathological and genotypic study of 40 cases. Hum Pathol. 1999;30(9):1104-1112.
11. Brady SP, Magro CM, Dia-Cano SJ, et al. Analysis of clonality of atypical cutaneous lymphoid infiltrates associated with drug therapy by PCR/DGGE. Hum Pathol. 1999;30:130-136.
12. Magro CM, Morrison C, Kovatich A, et al. Drug induced reversible lymphoid dyscrasia: A clonal lymphoinatoid dermatitis of memory and activated T cells. Lab Invest. 2001;81:70A (abstr).
13. Nuovo GJ, Morrison C. Porcu P Caliguiri M, Suster S. In situ determination of T-cell receptor beta expression patterns. J Histochem Cytochem. 2001;49:139-146.
14. Nuovo GJ. PCR In situ Hybridization Protocols and Applications. 3rd ed. New York, NY: Lippincott-Raven Press, 1997.
15. Nuovo GJ, Baylin SB, Bolinsky S, et al. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci U S A. 1999;96:12754-12759.
16. Lynas C, Howe D. Additional TCRV beta primers and minor method modifications improve detection of clonal T-cell populations by RT-PCR. Mol Pathol. 1997;50:53-55.
17. Magro CM, Crowson AN, Harrist T. Atypical lymphoid infiltrates in cutaneous lesions of connective tissue disease. Am J Dermatopathol. 1997;19:446-455.
18. Kadin ME, Vonderheid EC, Sako D, et al. Clonal composition of T cells in lymphomatoid papulosis. Am J Pathol. 1987;126:13-17.
19. Ko JW, Seong JY, Suh KS, et al. Pitriasis lichenoides-like mycosis fungoides in children. Br J Dermatol. 2000;142:347-352.
20. Uppenkamp M, Pittalugra S, Lipford EH, et al. Limited diversity and selection of rearranged gamma genes in polyclonal T cells. J Immunol. 1987;138:1618-1620.
21. Magro CM, Crowson AN. Drug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates. Hum Pathol. 1996;27:125-132.
22. Crowson AN, Magro CM. Antidepressant therapy: A possible cause of atypical cutaneous lymphoid hyperplasia. Arch Dermatol. 1995;131:919-922.
23. Magro CM, Crowson AN. Drugs with anti-histaminic properties as a cause of atypical cutaneous lymphoid hyperplasia. J Am Acad Dermatol. 1995;32:419-428.