Is oral azithromycin effective for the treatment of cyclosporine-induced gingival hyperplasia in cardiac transplant recipients?

Journal of Clinical Pharmacy and Therapeutics

Volumn 28, Issue 4, 2003, Pages 329-338

  Strachan, D ^a   Burton, I ^a   Pearson, Glen J ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Azithromycin; Cyclosporine; Drug induced; Gingival hyperplasia; Heart transplantation; Treatment

Indexed keywords

AZITHROMYCIN; CYCLOSPORIN A;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; GINGIVA HYPERPLASIA; HEART TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; MEDICAL LITERATURE; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; CYCLOSPORINE; GINGIVAL HYPERPLASIA; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED;

EID: 0042881038     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2710.2003.00494.x     Document Type: Article

References (18)

1. Laupacis A, for the Canadian transplant study group (1983) Complications of cyclosporine therapy: a comparison to azathioprine. Transplantation Proceedings, 15(Suppl. 1), 2748-2753.
2. Allman SD, McWhorter AG, Seale NS (1994) Evaluation of cyclosporin-induced gingival overgrowth in the pediatric transplant patient. Pediatric Dentistry, 16, 36-40.
3. Montebugnoli L, Bernardi F, Magelli C (1996) Cyclosporin-A-induced gingival overgrowth in heart transplant patients. A cross-sectional study. Journal of Clinical Peridontology, 23, 868-872.
4. Botha PJ (1997) Drug-induced gingival hyperplasia and its management - a literature review. Journal of the Dental Association of South Africa, 52, 659-664.
5. Hood KA (2002) Drug-induced gingival hyperplasia in transplant recipients. Progress in Transplantation, 12, 17-23.
6. Boran M, Gunes Z, Doruk F, Gonenc F, Cetin S (1996) Improvement in cyclosporine A associated gingival hyperplasia with azithromycin therapy. Transplantation Proceedings, 28, 2316.
7. Nowicki M, Kokot F, Wiecek A (1998) Partial regression of advanced cyclosporin-induced gingival hyperplasia after treatment with azithromycin. A case report. Annals of Transplantation, 3, 25-27.
8. Wahlstrom E, Zamora JU, Teichman S (1995) Improvement in cyclosporine-associated gingival hyperplasia with azithromycin therapy. The New England Journal of Medicine, 332, 753-754.
9. Nash M, Zaltzman JS (1998) Efficacy of azithromycin in the treatment of cyclosporine-induced gingivial hyperplasia in renal transplant recipients. Transplantation, 65, 1611-1615.
10. Puig J, Lloveras J, Bosch JM, Munne A, Mir M, Barbosa F, Masramon J (1997) Treatment of gingival hyperplasia secondary to cyclosporine by the new macrolide azithromycin. Transplantation Proceedings, 29, 2379-2380.
11. Citterio F, Di Pinto A, Borzi MT, Scata MC, Foco M, Pozzetto U, Castagneto M (2001) Azithromycin treatment of gingival hyperplasia in kidney transplant recipients is effective and safe. Transplantation Proceedings, 33, 2134-2135.
12. Gomez E, Sanchez-Nunez M, Sanchez JE et al. (1997) Treatment of cyclosporine-induced gingival hyperplasia with azithromycin. Nephrology Dialysis Transplantation, 12, 2694-2697.
13. Ljutic D (1997) Successful treatment of cyclosporine-associated gingival hyperplasia with azithromycin therapy: a case report. Dialysis & Transplantation, 26, 787-788.
14. Wirnsberger G, Pfragner R, Mauric A, Zach R, Bogiatzis A, Holzer H (1998) Effect of antibiotic treatment with azithromycin on cyclosporine A-induced gingival hyperplasia among renal transplant recipients. Transplantation Proceedings, 30, 2117-2119.
15. Bourge RC, Kirklin JK, Naftel DC, Figg WD, Hite-Williams C, Ketchum C (1991) Diltiazem-cyclosporine interaction in transplant recipients: impact on cyclosporine dose and medication costs. American Journal of Medicine, 90, 402-404.
16. Campana C, Regazzi MB, Buggia I, Molinaro M (1996) Clinically significant drug interactions with cyclosporin: an update. Clinical Pharmacokinetics, 30, 141-179.
17. Guyatt GH, Haynes RB, Jaeschke RZet al. for the Evidence-Based Medicine Working Group (2000) Users' Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users' Guides to patient care. Journal of the American Medical Association, 284, 1290-1296.
18. Easterbrook P, Berlin J, Gopalan R, Matthews D (1991) Publication bias in clinical research. Lancet, 337, 867-872.