Productive HIV-2 infection in the brain is restricted to macrophages/microglia

AIDS

Volumn 17, Issue 10, 2003, Pages 1451-1455

  Mörner, Andreas ^a,b,e   Thomas, J Alero ^c   Bjiörling, Ewa ^b   Munson, Philippa J ^a   Lucas, Sebastian B ^d   McKnight, Áine ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d ST THOMAS HOSPITAL   (United Kingdom)

^e SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

Author keywords

Brain; HIV 2; Macrophages; Microglia; Tropism

Indexed keywords

ANTIBODY; CD45 ANTIGEN; CD68 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; AUTOPSY; CAUSE OF DEATH; CELL GROWTH; CELL INFILTRATION; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; NEUROPATHOLOGY; OLIGODENDROGLIA; PRIORITY JOURNAL; SEROLOGY; VIRUS ENCEPHALITIS; VIRUS PATHOGENESIS;

ADULT; AIDS DEMENTIA COMPLEX; ANTIGENS, CD; ANTIGENS, CD45; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BRAIN; FEMALE; GENE PRODUCTS, GAG; GLIAL FIBRILLARY ACIDIC PROTEIN; HIV ANTIGENS; HIV-1; HIV-2; HUMANS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MICROGLIA; MIDDLE AGED;

EID: 0042869862     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200307040-00005     Document Type: Article

References (30)

1. McArthur JC, Hoover DR, Bacellar H, Miller EN, Cohen BA, Becker JT, et al. Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study. Neurology 1993, 43:2245-2252.
2. Dwyer DE, Matheron S, Bakchine S, Bechet JM, Montagnier L, Vazeux R. Detection of human immunodeficiency virus type 2 in brain tissue. J Infect Dis 1992, 166:888-891.
3. Hormigo A, Bravo-Marques JM, Souza-Ramalho P, Pimentel J, Teixeira C, Martins R. Uveomeningoencephalitis in a human immunodeficiency virus type 2-seropositive patient. Ann Neurol 1988, 23:308-310.
4. Rolfe M. HIV-2 and its neurological manifestations. S Afr Med J 1994, 84:503-505.
5. Livrozet JM, Ninet J, Vighetto A, Touraine JL, Touraine F, Caudie C, et al. One case of HIV-2 AIDS with neurological manifestations [letter]. J Acquir Immune Defic Syndr 1990, 3:927-928.
6. Belec L, Martin PM, Georges-Courbot MC, Brogan T, Gresenguet G, Mathiot CC, et al. Dementia as the primary manifestation of HIV2 infection in a Central African patient. Ann Inst Pasteur Virol 1988, 139:291-294.
7. Klemm E, Schneweis KE, Horn R, Tackmann W, Schulze G, Schneider J. HIV-II infection with initial neurological manifestation. J Neurol 1988, 235:304-307.
8. Sharer LR. Pathology of HIV-1 infection of the central nervous system. A review. J Neuropathol Exp Neurol 1992, 51:3-11.
9. Lucas SB, Hounnou A, Peacock C, Beaumel A, Djomand GM, Ng J, et al. The mortality and pathology of HIV infection in a west African city. AIDS 1993, 7:1569-1579.
10. Ministério da Saúde. SIDA - A situação em Portugal a 30 de Junho de 2001. Lisbon: Instituto Nacional de Sáude: 2001.
11. Vazeux R, Brousse N, Jarry A, Henin D, Marche C, Vedrenne C, et al. AIDS subacute encephalitis. Identification of HIV-infected cells. Am J Pathol 1987, 126:403-410.
12. Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986, 233:1089-1093.
13. Brinkmann R, Schwinn A, Muller J, Stahl-Hennig C, Coulibaly C, Hunsmann G, et al. In vitro and in vivo infection of rhesus monkey microglial cells by simian immunodeficiency virus. Virology 1993, 195:561-568.
14. Lackner AA, Smith MO, Munn RJ, Martfeld DJ, Gardner MB, Marx PA, et al. Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991, 139:609-621.
15. Ward JM, O'Leary TJ, Baskin GB, Benveniste R, Harris CA, Nara PL, et al. Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am J Pathol 1987, 127:199-205.
16. Jordan CA, Watkins BA, Kufta C, Dubois-Dalcq M. Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent. J Virol 1991, 65:736-742.
17. Lavi E, Strizki JM, Ulrich AM, Zhang W, Fu L, Wang Q, et al. CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons. Am J Pathol 1997, 151:1035-1042.
18. Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL. Chemokines and receptors in HIV encephalitis. AIDS 1998, 12:1021-1026.
19. He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, et al. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 1997, 385:645-649.
20. Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 1998, 153:31-37.
21. van der Meer P, Ulrich AM, Gonzalez-Scarano F, Lavi E. Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Exp Mol Pathol 2000, 69:192-201.
22. Warty D, Lane TE, Streb M, Fox HS. Transfer of neuropathogenic simian immunodeficiency virus with naturally infected microglia. Am J Pathol 1995, 146:914-923.
23. Everall IP, Luthert PJ, Lantos PL. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991, 337:1119-1121.
24. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 1999, 13:1-22.
25. Brack-Werner R, Kleinschmidt A, Ludvigsen A, Mellert W, Neumann M, Herrmann R, et al. Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 1992, 6:273-285.
26. Clapham PR, McKnight A. Cell surface receptors, virus entry and tropism of primate lentiviruses. J Gen Virol 2002, 83:1809-1829.
27. Reeves JD, Hibbitts S, Simmons G, McKnight Á, Azevedo-Pereira JM, Moniz-Pereira J, et al. Primary human immunodeficiency virus type 2 (HIV-2) isolates infect CD4- negative cells via CCR5 and CXCR4: comparison with HIV-1 and simian immunodeficiency virus and relevance to cell tropism in vivo. J Virol 1999, 73:7795-7804.
28. Williams KC, Corey S, Westmoreland SV, Pauley D, Knight H, deBakker C, et al. Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: implications for the neuropathogenesis of AIDS. J Exp Med 2001, 193:905-915.
29. Hesselgesser J, Horuk R. Chemokine and chemokine receptor expression in the central nervous system. J Neurovirol 1999, 5:13-26.
30. Thomas E, R. Shotton C, Weiss RA, Clapham PR, McKnight A. CD4-dependence versus CD4-independence of HIV-2: consequences for neutralization. AIDS 2003, 17:291-300.