Bimodal δ-opioid receptors regulate vagal bradycardia in canine sinoatrial node

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 285, Issue 3 54-3, 2003, Pages

  Farias, M ^a   Jackson, K ^a   Yoshishige, D ^a   Caffrey, J L ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Enkephalins; Heart rate; Microdialysis; Opiate receptors; Parasympathetic nervous system

Indexed keywords

7 BENZYLIDENENALTREXONE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DELTA 1 OPIATE RECEPTOR; DELTA 2 OPIATE RECEPTOR; DELTA OPIATE RECEPTOR; ENKEPHALIN; METENKEPHALIN[6 ARGININE 7 PHENYLALANINE]; NALTRINDOLE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DOG; HEART RATE; MICRODIALYSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; SINUS NODE; VAGUS NERVE STIMULATION;

EID: 0042860010     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00353.2003     Document Type: Article

References (34)

1. Babai L, Papp JG, Parratt JR, and Vegh A. The antiarrhythmic effects of ischemic preconditioning in anesthetized dogs are prevented by atropine: role of changes in baroreceptor reflex sensitivity. Br J Pharmacol 135: 55-64, 2002.
2. Barron BA, Gu H, Gaugl JF, and Caffrey JL. Screening for opioids in dog heart. J Mol Cell Cardiol 24: 67-77, 1992.
3. Billman GE, Schwartz PJ, and Stone HL. The effects of daily exercise on the susceptibility to sudden cardiac death. Circulation 69: 1182-1189, 1984.
4. Boluyt MO, Younes A, Caffrey JL, O'Neill L, Barron BA, Crow MT, and Lakatta EG. Age-associated increase in rat cardiac opioid production. Am J Physiol Heart Circ Physiol 265: H212-H218, 1993.
5. Caffrey JL. Enkephalin/catecholamine interactions in cardiac, skeletal and intestinal muscle. J Am Osteopath Assoc 84, Suppl 1: 135-142, 1984.
6. Caffrey JL. Enkephalin inhibits vagal control of heart rate, contractile force, and coronary blood flow in the canine heart in vivo. J Auton Nerv Syst 2318: 1-8, 1999.
7. Caffrey JL, Boluyt MO, Younes A, Barron BA, O'Neill L, Crow MT, and Lakatta EG. Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat. J Mol Cell Cardiol 26: 701-711, 1994.
8. Caffrey JL, Mateo Z, Napier LD, Gaugl JF, and Barron BA. Intrinsic cardiac enkephalins inhibit vagal bradycardia in the dog. Am J Physiol Heart Circ Physiol 268: H848-H855, 1995.
9. Chien GL and Van Winkle DM. Naloxone blockade of myocardial ischemic preconditioning is stereoselective. J Mol Cell Cardiol 28: 1895-1900, 1996.
10. Crain SM and Shen KF. Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM'1 ganglioside-regulated opioid receptor functions. Trends Pharmacol Sci 19: 358-365, 1998.
11. Farias M, Jackson KE, Stanfill A, and Caffrey JL. Prejunctional opiate receptors in the SA node moderate vagal bradycardia. Auton Neurosci 87: 9-15, 2001.
12. 2-opioid receptors in sinoatrial node. Am J Physiol Heart Circ Physiol 284: H1693-H1701, 2003.
13. Howells RD, Kilpatrick DL, Bailey LC, Noe M, and Udenfriend S. Proenkephalin mRNA in rat heart. Proc Natl Acad Sci USA 83: 1960-1963, 1986.
14. Hughes J, Kosterlitz HW, and Smith TW. The distribution of methionine-enkephalin and leucine-enkephalin in the brain and peripheral tissues. Br J Pharmacol 61: 639-647, 1977.
15. Jackson KE, Farias M, Stanfill A, and Caffrey JL. Delta opioid receptors inhibit vagal bradycardia in the sinoatrial node. J Cardiovasc Pharmacol Ther 6: 385-393, 2001.
16. Jackson KE, Farias M, Stanfill A, and Caffrey JL. Transient arterial occlusion raises enkephalin in the sinoatrial node and improves vagal bradycardia. Auton Neurosci 94: 84-92, 2001.
17. Kleiger R, Miller JP, Bigger JT Jr, and Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59: 256-262, 1987.
18. Low KG, Allen RG, and Melner MH. Association of proenkephalin transcripts with polyribosomes in the heart. Mol Endocrinol 4: 1408-1415, 1990.
19. Lang RE, Hermann K, Dietz R, Gaida W, Ganten D, Kraft K, and Unger T. Evidence for the presence of enkephalins in the heart. Life Sci 32: 399-406, 1983.
20. ATP channels. Circ Res 84: 1396-1400, 1999.
21. Mateo Z, Napier LD, Gaugl JF, Barron BA, and Caffrey JL. Hemorrhage alters plasma and cardiac enkephalins and catecholamines in anesthetized dogs. Am J Physiol Heart Circ Physiol 269: H2082-H2089, 1995.
22. Miki T, Cohen MV, and Downey JM. Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits. Mol Cell Biochem 186: 3-12, 1998.
23. Musha T, Satoh E, Koyanagawa H, Kimura T, and Satoh S. Effects of opioid agonists on sympathetic and parasympathetic transmission to the dog heart. J Pharmacol Exp Ther 250: 1087-1091, 1999.
24. Patey G, Cupo A, Mazarguil H, Morgat J-L, and Rossier J. Release of proenkephalin-derived opioid peptides from rat striatum in vitro and their rapid degradation. Neuroscience 15: 1035-1044, 1985.
25. Sarne Y, Fields A, Keren O, and Gafni M. Stimulatory effects of opioids on transmitter release and possible cellular mechanisms: overview and original results. Neurochem Res 21: 1353-1361, 1996.
26. ATP channels. Am J Physiol Heart Circ Physiol 274: H909-H914, 1998.
27. 1- but not μ- or κ-opioid receptors. Circulation 97: 1282-1289, 1998.
28. Schultz JE, Hsu AK, and Gross GJ. Ischemic preconditioning and morphine-induced cardioprotection involve the delta (δ)-opioid receptor in the intact rat heart. J Mol Cell Cardiol 29: 2187-2195, 1997.
29. Schultz JE, Hsu AK, and Gross GJ. Ischemic preconditioning is mediated by a peripheral opioid receptor mechanism in the intact rat heart. J Mol Cell Cardiol 29: 1355-1362, 1997.
30. Springhorn JP and Claycomb WC. Translation of heart preproenkephalin mRNA and secretion of enkephalin peptides from cultured cardiac myocytes. Am J Physiol Heart Circ Physiol 263: H1560-H1566, 1992.
31. Van Wylen DG, Willis J, Sodhi J, Weiss RJ, Lasley RD, and Mentzer RM Jr. Cardiac microdialysis to estimate interstitial adenosine and coronary blood flow. Am J Physiol Heart Circ Physiol 258: H1642-H1649, 1990.
32. Weitzell R, Illes P, and Starke K. Inhibition via opioid μ- and δ-receptors of vagal transmission in rabbit isolated heart. Naunyn Schmiedebergs Arch Pharmacol 328: 186-190, 1984.
33. Yao Z and Gross GJ. Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism in dogs. Am J Physiol Heart Circ Physiol 264: H2221-H2225, 1993.
34. Younes A, Pepe S, Barron BA, Surgeon HA, Lakatta EG, and Caffrey JL. Cardiac synthesis, processing, and coronary release of enkephalin-related peptides. Am J Physiol Heart Circ Physiol 279: H1989-H1998, 2000.